Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $121,112
Workers Compensation Claims Examiner | Riverside, CA
$85K - $105K *
Join us to analyze and adjudicate complex workers compensation claims, delivering innovative solutions in a dynamic environment. Collaborate with clients across industries while enjoying professional...
5 days ago
Principal Product Manager, GRC
$150K - $180K *
Drive product strategy and execution for a critical portfolio area, leading cross-functional teams to transform user insights into impactful software solutions while mentoring others and shaping platf...
5 days ago
$110K - $130K *
Lead the charge in shaping product marketing strategies that drive adoption and pipeline. Collaborate with cross-functional teams to craft compelling narratives and ensure our differentiated value res...
5 days ago
$77K - $126K *
Lead the charge in managing complex construction projects, ensuring financial success and customer satisfaction while collaborating with stakeholders and subcontractors to deliver exceptional results...
5 days ago
$130K - $140K *
Elevate your career by joining a dynamic team to design and implement innovative cloud solutions in a multi-cloud environment, ensuring scalability, security, and alignment with business objectives wh...
5 days ago
Medical Science Liaison - Senior Medical Liaison - Mid Atlantic Region
$162K - $203K *
Champion scientific engagement by building relationships with key opinion leaders in Urology and Women's Health. Leverage expertise to support medical strategies and enhance product knowledge across t...
5 days ago
ServiceNow Mid-Level Developer
$130K - $150K *
Elevate employee experiences by designing and implementing HR solutions. Lead technical projects, optimize integrations with Microsoft 365, and mentor developers to enhance ServiceNow capabilities and...
5 days ago
$150K - $180K *
Champion the growth of our commercial engine by leading business development efforts, forging strategic partnerships, and driving revenue as quantum computing transitions to enterprise applications. C...
5 days ago
Associate Director, Clinical Supply Chain (Remote)
$150K - $185K *
Architect comprehensive clinical supply strategies for global trials. Collaborate across functional teams to secure timely, compliant drug supply while managing risks and inventory effectively, ensuri...
Reposted 5 days ago
Commercial Operations Manager (Remote)
$115K - $140K *
Drive operational excellence in commercial readiness and support cross-functional teams to ensure effective execution of launch strategies and operational priorities in a dynamic biotech environment...
Reposted 5 days ago
Senior Director, Quality Assurance (Remote)
$225K - $275K *
Optimize quality assurance processes to ensure compliance with regulatory standards and drive improvements across all operations. Lead a talented team to establish and maintain an effective Quality Ma...
Reposted 5 days ago
Sr Strategic Account Manager (Director)-IMB
$132K - $207K *
Elevate your career by driving growth in the mortgage industry, partnering with top lenders to enhance FICO's analytics solutions. Lead strategic initiatives, foster client relationships, and deliver...
5 days ago
$200K - $225K *
Transform marketing strategies to drive growth and engagement across public and private sectors. Lead integrated marketing efforts, brand positioning, and customer marketing services while leveraging...
5 days ago
Associate Director, US Pricing, Contracting and Channel Strategy
$157K - $256K *
Shape strategic pricing and channel strategies for innovative therapies, ensuring patient access and affordability. Lead cross-functional initiatives, optimize distribution models, and drive market in...
5 days ago
Account Executive, Maestro PMS
$120K - $182K *
Accelerate growth by driving new software sales, building client relationships, and tailoring solutions to meet unique business needs. Collaborate with cross-functional teams to ensure a seamless cust...
5 days ago
$85K - $105K *
Optimize regulatory compliance processes for a multi-state transportation network. Collaborate cross-functionally to ensure operational readiness and manage ongoing compliance across diverse markets...
5 days ago
Staff Product Manager, Pricing
$168K - $210K *
Transform pricing strategies by leading cross-functional teams to enhance decision-making and model deployment. Drive the evolution of pricing platforms, integrating advanced AI to streamline workflow...
5 days ago
Physician, Family Medicine - Telemedicine Opportunity - DrHouse
$210K *
Elevate patient care by delivering high-quality telehealth services across South Dakota. Join a compassionate team of board-certified physicians managing diverse clinical cases through innovative virt...
5 days ago
$120K - $150K *
Elevate your career by driving enterprise sales for innovative solutions. Engage with multinational accounts, build strategic relationships, and lead complex negotiations to unlock growth opportunitie...
5 days ago
$150K - $180K *
Shape strategic sales initiatives targeting Fortune 2000 accounts. Drive complex sales cycles, engage with C-suite leaders, and leverage AI solutions to meet revenue goals while building a robust pipe...
5 days ago
$90K - $110K *
Empower quality assurance by developing AI-assisted automated tests, integrating them into CI/CD pipelines, and collaborating with cross-functional teams to enhance software reliability and release ef...
5 days ago
FlexPoint Sales Account Manager - California (Base Pay Plus Commission)
$59K - $118K *
Drive revenue growth by managing customer accounts and pursuing new sales opportunities. Utilize consultative strategies to build relationships and meet sales quotas while serving as a trusted advisor...
Reposted 5 days ago
$114K - $167K *
Engineer innovative ERP solutions by analyzing complex business processes, defining architecture, and leading integration efforts to optimize performance and ensure compliance. Drive impactful customi...
5 days ago
Account Manager-Employee Group Benefits
$76K - $129K *
Join us to build strong relationships with key policyholders through proactive communication and skilled negotiation. You'll bridge clients and the home office, tackling concerns and driving improveme...
5 days ago
Associate - Financial Planning & Analysis (FP&A)
$80K - $95K *
Empower your career by driving financial insights and analytics. Collaborate across teams to transform data into strategic decisions, enhancing growth and efficiency in a dynamic environment. Join us...
5 days ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.