Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$110K - $130K *

Empower transformative telehealth solutions by designing and implementing robust software infrastructure. Join a dynamic team to innovate, automate, and streamline applications, impacting the healthca...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$160K - $200K *

Shape the future of data center networking as a Principal Technologist, leading complex pre-sales engagement and architecture for AI infrastructure. Collaborate with top industry players to innovate s...

RemoteRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Enterprise Technology

$148K - $263K *

Manage and maintain Oracle databases, leveraging expertise in Unix scripting and PL/SQL. Engage in data migration, interface development, and automated task management while collaborating within a dyn...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Shape the future of content discovery by leading product operations and program management. Drive efficiency and innovation across teams, ensuring seamless collaboration and execution of high-impact i...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Hospitality & Recreation

$200K - $300K *

Drive product strategy and lifecycle management, ensuring alignment with market needs and business growth. Lead cross-functional teams to develop, launch, and support innovative medical devices while...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Champion technical solution design and deployment readiness, translating customer needs into secure, scalable architectures. Collaborate with engineering and cybersecurity teams to ensure successful t...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$229K - $260K *

Drive the technical direction for building and delivering containerized applications, ensuring reliability and security across deployments. Collaborate with teams to enhance automation and mentor engi...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$140K *

Drive regional sales success by leading a dynamic team, achieving revenue goals, and fostering collaboration. Utilize your expertise in capital medical equipment sales to mentor Territory Managers and...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Unlock your potential by leading quality initiatives and training programs to enhance team performance and compliance. Collaborate with management to drive operational excellence and support colleague...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$229K - $260K *

Lead the charge in designing and implementing a robust OTA update system, ensuring seamless deployment across diverse environments while mentoring engineers and driving technical excellence in distrib...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$110K - $118K *

Engage in driving revenue growth by expanding strategic partnerships and acquiring new enterprise clients. Merge expansion selling with net-new enterprise acquisition to establish a repeatable sales m...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Business Services

$180K - $225K *

Join a team that's redefining semiconductor IP licensing. Drive complex sales cycles, engage with key stakeholders, and build long-term relationships that generate significant revenue in a fast-paced...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Join a team that's shaping the future of enterprise sales in financial services. Drive strategy and execution across banking, insurance, and fintech, while building a high-performing team to navigate...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$117K - $259K *

Innovate in quality control and stability oversight, leading analytical testing and compliance efforts across multiple programs to support clinical and commercial development in a dynamic, remote envi...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $158K *

Champion operational excellence by leading facilities management across a multi-state portfolio. Drive strategic initiatives, optimize vendor performance, and implement scalable processes to support o...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$120K - $150K *

Lead the charge in driving growth through data-driven insights, optimizing subscription funnels, and implementing impactful changes across marketing and product initiatives to enhance user engagement...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Hospitality & Recreation

$100K - $120K *

Engage in strategic partnership management to drive growth and innovation, overseeing development, negotiation, and execution of pivotal alliances. Collaborate cross-functionally to ensure alignment...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$75K - $150K *

Shape the future of mortgage sales by leading a high-performing team of Loan Officers. Drive exceptional performance, foster accountability, and enhance customer experiences in a fast-paced, collabora...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $135K *

Lead the strategic planning and execution of complex programs across multiple teams, ensuring alignment with business priorities and effective risk management. Drive delivery improvements and maintain...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$160K - $170K *

Transform user experiences by creating impactful product education and training. Collaborate cross-functionally to enhance product adoption, streamline communication, and drive measurable user success...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$82K - $149K *

Accelerate your career by providing logistics expertise for critical Air Force systems. Join a dynamic team to optimize resource flow, manage international shipments, and ensure successful delivery of...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Technical Services

$125K - $150K *

Transform revenue operations by owning the bottoms-up revenue model, partnering with leadership to drive strategic planning and analysis, and ensuring alignment with growth targets in a dynamic, high...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Legal & Accounting

$135K - $225K *

Lead the evolution of Workday HCM solutions by integrating technical expertise with strategic vision, ensuring optimal user experiences and alignment with enterprise goals while managing architecture...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Business Services

$90K - $132K *

Join a team that's redefining network infrastructure for healthcare solutions. You'll design, implement, and support advanced wired and wireless networks, ensuring seamless connectivity and optimal pe...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$68K - $113K *

Empower healthcare transformation by joining a dynamic team focused on solving complex revenue cycle challenges through analytics and automation, while gaining exposure to diverse projects and collabo...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.