Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$110K - $130K *
Empower transformative telehealth solutions by designing and implementing robust software infrastructure. Join a dynamic team to innovate, automate, and streamline applications, impacting the healthca...
Reposted yesterday
Principal Technologist - AI and Data Center Networking
$160K - $200K *
Shape the future of data center networking as a Principal Technologist, leading complex pre-sales engagement and architecture for AI infrastructure. Collaborate with top industry players to innovate s...
Reposted yesterday
$148K - $263K *
Manage and maintain Oracle databases, leveraging expertise in Unix scripting and PL/SQL. Engage in data migration, interface development, and automated task management while collaborating within a dyn...
Yesterday
Senior Product Operations Lead & Program Manager - Content Experience Innovation
$150K - $180K *
Shape the future of content discovery by leading product operations and program management. Drive efficiency and innovation across teams, ensuring seamless collaboration and execution of high-impact i...
Reposted yesterday
$200K - $300K *
Drive product strategy and lifecycle management, ensuring alignment with market needs and business growth. Lead cross-functional teams to develop, launch, and support innovative medical devices while...
Yesterday
$110K - $130K *
Champion technical solution design and deployment readiness, translating customer needs into secure, scalable architectures. Collaborate with engineering and cybersecurity teams to ensure successful t...
Yesterday
Staff Software Engineer, Image Build & Release
$229K - $260K *
Drive the technical direction for building and delivering containerized applications, ensuring reliability and security across deployments. Collaborate with teams to enhance automation and mentor engi...
Yesterday
Regional Sales Manager - Southeast
$140K *
Drive regional sales success by leading a dynamic team, achieving revenue goals, and fostering collaboration. Utilize your expertise in capital medical equipment sales to mentor Territory Managers and...
Yesterday
Manager - Total Performance | WC, GL, AUTO and PD
$95K - $115K *
Unlock your potential by leading quality initiatives and training programs to enhance team performance and compliance. Collaborate with management to drive operational excellence and support colleague...
Yesterday
Staff Software Engineer, OTA Services
$229K - $260K *
Lead the charge in designing and implementing a robust OTA update system, ensuring seamless deployment across diverse environments while mentoring engineers and driving technical excellence in distrib...
Yesterday
Director, Strategic Solutions Sales
$110K - $118K *
Engage in driving revenue growth by expanding strategic partnerships and acquiring new enterprise clients. Merge expansion selling with net-new enterprise acquisition to establish a repeatable sales m...
Reposted yesterday
Regional Sales Executive- North America
$180K - $225K *
Join a team that's redefining semiconductor IP licensing. Drive complex sales cycles, engage with key stakeholders, and build long-term relationships that generate significant revenue in a fast-paced...
Reposted yesterday
Sales Lead - Enterprise - Financial Services
$150K - $180K *
Join a team that's shaping the future of enterprise sales in financial services. Drive strategy and execution across banking, insurance, and fintech, while building a high-performing team to navigate...
Reposted yesterday
Director, External Quality Control & Stability
$117K - $259K *
Innovate in quality control and stability oversight, leading analytical testing and compliance efforts across multiple programs to support clinical and commercial development in a dynamic, remote envi...
Yesterday
$120K - $158K *
Champion operational excellence by leading facilities management across a multi-state portfolio. Drive strategic initiatives, optimize vendor performance, and implement scalable processes to support o...
Yesterday
Director of Growth - Consumer Subscription App (Fully Remote)
$120K - $150K *
Lead the charge in driving growth through data-driven insights, optimizing subscription funnels, and implementing impactful changes across marketing and product initiatives to enhance user engagement...
Yesterday
Strategic Partnerships Manager
$100K - $120K *
Engage in strategic partnership management to drive growth and innovation, overseeing development, negotiation, and execution of pivotal alliances. Collaborate cross-functionally to ensure alignment...
Reposted yesterday
$75K - $150K *
Shape the future of mortgage sales by leading a high-performing team of Loan Officers. Drive exceptional performance, foster accountability, and enhance customer experiences in a fast-paced, collabora...
Reposted yesterday
Advanced Specialist, Project Management
$125K - $135K *
Lead the strategic planning and execution of complex programs across multiple teams, ensuring alignment with business priorities and effective risk management. Drive delivery improvements and maintain...
Reposted yesterday
Sr. Product Enablement Manager
$160K - $170K *
Transform user experiences by creating impactful product education and training. Collaborate cross-functionally to enhance product adoption, streamline communication, and drive measurable user success...
Yesterday
$82K - $149K *
Accelerate your career by providing logistics expertise for critical Air Force systems. Join a dynamic team to optimize resource flow, manage international shipments, and ensure successful delivery of...
Yesterday
Staff Revenue Operations Manager, Revenue Planning & Analytics
$125K - $150K *
Transform revenue operations by owning the bottoms-up revenue model, partnering with leadership to drive strategic planning and analysis, and ensuring alignment with growth targets in a dynamic, high...
Yesterday
$135K - $225K *
Lead the evolution of Workday HCM solutions by integrating technical expertise with strategic vision, ensuring optimal user experiences and alignment with enterprise goals while managing architecture...
Yesterday
$90K - $132K *
Join a team that's redefining network infrastructure for healthcare solutions. You'll design, implement, and support advanced wired and wireless networks, ensuring seamless connectivity and optimal pe...
Yesterday
Healthcare Financial Transformation - Automation & Analytics - Consultant
$68K - $113K *
Empower healthcare transformation by joining a dynamic team focused on solving complex revenue cycle challenges through analytics and automation, while gaining exposure to diverse projects and collabo...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.