Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$135K - $160K *

Elevate security practices by building and managing a comprehensive security program. Collaborate with engineers to identify vulnerabilities, implement automated checks, and ensure robust protection a...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $110K *

Lead third-party food safety audits, ensuring compliance with industry standards. Collaborate with audit teams, train new auditors, and maintain certification credentials while traveling extensively a...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$95K - $120K *

Unlock potential by serving as a technical partner to sales, providing expertise in automation solutions. Manage application opportunities, engage with customers, and recommend improvements to align t...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$130K - $160K *

Join a team that's dedicated to delivering data-driven solutions for life sciences clients. Leverage your expertise to drive insights, optimize user experiences, and collaborate with cross-functional...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Transform warehouse operations by leveraging your SAP EWM expertise. In this role, you’ll optimize solutions, deliver hands-on support, and collaborate with cross-functional teams to elevate logistics...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$109K - $160K *

Transform your career by managing web production and enhancing user experiences. Collaborate with cross-functional teams to prioritize projects, execute testing roadmaps, and optimize web performance...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$115K - $150K *

Join a team that's dedicated to advancing clean energy by developing and owning plant process simulation models. Collaborate across disciplines to enhance design, operations, and plant dynamics for in...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$230K - $260K *

Lead the charge in client migrations, owning the entire technical lifecycle from legacy analysis to deployment, ensuring precision and collaboration across teams for optimal outcomes...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Information Technology

$177K - $221K *

Manage the strategy and execution of access marketing for oncology products, focusing on value propositions for payers and healthcare providers. Collaborate with cross-functional teams to ensure effec...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$211K - $235K *

Drive patient access initiatives by leveraging oncology expertise to navigate reimbursement landscapes, educate stakeholders, and resolve complex access issues, ensuring timely therapy access for pati...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$82K - $150K *

Elevate your career by driving growth in the dental implant market. This role focuses on acquiring new customers, expanding market share, and positioning value-driven solutions, requiring a proactive...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $120K *

Drive sales success by building relationships with dental professionals, promoting innovative products, and achieving targets. Leverage your expertise to deliver exceptional customer service and suppo...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$151K - $203K *

Shape the future of marketing by building systems that unify messaging, drive growth, and enhance customer engagement across departments. Collaborate with teams to create impactful strategies that sup...

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Champion project delivery by overseeing HV cable testing projects across North America. Ensure alignment with client expectations while managing resources, schedules, and budgets for successful comple...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$157K - $224K *

Champion the evolution of developer tooling and CI/CD pipelines, leading a global team to enhance operational efficiency and drive platform modernization for a multi-tenant SaaS environment, ensuring...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$74K - $114K *

Innovate solutions in manufacturing by developing methods and tooling to enhance production efficiency. Collaborate with teams to implement Lean Principles and drive continuous improvement in a dynami...

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $140K *

Shape the future of industrial water solutions by driving sales growth, managing key accounts, and fostering enduring partnerships with customers and teams to enhance sustainable business outcomes and...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $100K *

Unlock potential by leading accurate project estimates in commercial construction. Collaborate with teams to deliver competitive bids and enhance project outcomes while developing your skills in a dyn...

3 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead supplier quality initiatives to ensure product conformity and drive continuous improvement. Collaborate with cross-functional teams to establish quality standards, manage audits, and enhance supp...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$115K - $160K *

Join a team that's dedicated to enhancing global security through advanced incident response and forensic analysis. Collaborate with top professionals to protect organizations from sophisticated threa...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Join a team that's driving digital transformation by spearheading sales in Application Modernization Services, leveraging AI trends to cultivate strategic client relationships and optimize business gr...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Technical Services

$75K - $90K *

Transform financial insights into strategic initiatives, supporting planning and analysis as the organization scales. Collaborate across teams to enhance budget management, reporting, and performance...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$102K - $141K *

Join a team that's dedicated to enhancing sales performance through strategic process development, technology alignment, and targeted training. Collaborate with cross-functional teams to drive effecti...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Engage in comprehensive assessments of building performance and energy efficiency. Collaborate with clients to enhance sustainability practices while reducing operational costs through detailed audits...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$85K - $102K *

Elevate your career by reviewing and editing environmental and property assessments. Collaborate with field staff to ensure report accuracy and quality, while providing technical guidance and maintain...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.