Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$90K - $117K *
Elevate your career by leading SDTM programming activities, ensuring quality deliverables, and collaborating cross-functionally to optimize clinical data transformation in a dynamic environment...
3 days ago
$128K - $250K *
Innovate enterprise sales by leading the strategy for large deal pursuits, engaging C-suite clients, and delivering transformative solutions in retail and logistics sectors...
Reposted 3 days ago
$125K - $145K *
Lead campaign strategy and execution for oncology pharma marketing, driving performance optimization and cross-functional collaboration. Own end-to-end campaign management, ensuring alignment with bus...
Reposted 3 days ago
$170K - $220K *
Lead the charge in providing comprehensive legal support for the CHVAC segment, collaborating with global teams to ensure compliance and address complex legal matters while driving strategic initiativ...
3 days ago
$135K - $160K *
Lead the charge in quality and validation readiness for complex programs, uniting Engineering, Product, and Customer Success teams. Utilize AI and automation to streamline processes, enhance delivery...
3 days ago
Account Executive, HME Provider Sales
$80K - $100K *
Join a team that's driving growth by acquiring new customers and enhancing revenue through innovative solutions. Manage the full sales cycle while collaborating with cross-functional teams to ensure e...
3 days ago
Revenue Enablement Program Manager II
$91K *
Champion cross-functional programs that drive strategic outcomes, ensuring alignment with organizational priorities. Lead complex initiatives, manage risks, and foster stakeholder engagement to delive...
3 days ago
Medical Director, Post Acute Care
$207K - $346K *
Lead the charge in evidence-based medical case reviews to ensure high-quality patient care while collaborating with a network of over 500 physician colleagues in a fully remote environment...
Reposted 3 days ago
Electrical Manager MV - 100% Travel
$100K - $120K *
Transform the future of utility-scale solar projects by leading electrical operations, ensuring quality installations, and fostering strong team collaboration while managing contractor activities and...
3 days ago
$91K - $115K *
Transform the candidate experience by sourcing top talent for sales and corporate roles. Collaborate with recruiters and hiring managers to build pipelines, utilizing advanced sourcing techniques and...
3 days ago
Product Owner, AI & AWS Delivery
$110K - $130K *
Drive impactful AI and Agentforce delivery projects, managing customer relationships and internal initiatives. Leverage your strategic planning and analytical skills to oversee project execution and f...
3 days ago
$210K - $260K *
Elevate IT operations by leading system integration and security strategy. Own the full tech stack, streamline processes, and enhance patient care through automation and effective team management in a...
3 days ago
$95K - $115K *
Optimize patient access workflows by aligning registration with revenue cycle needs. Collaborate with stakeholders to enhance eligibility processes and improve patient estimates, while mentoring IS st...
3 days ago
$210K - $260K *
Transform the workplace culture and integration of two organizations, ensuring support for clinicians and staff while enhancing benefits, compensation, and recruitment strategies to foster a unified m...
3 days ago
$103K - $176K *
Transform downstream marketing for cutting-edge medical devices. Drive product launches, develop compelling content, analyze market trends, and ensure regulatory compliance across global regions while...
Reposted 3 days ago
Power Systems Study Engineer III
$104K - $130K *
Unlock potential by guiding complex power system studies for mission critical facilities. Collaborate with designers, manage projects independently, and leverage advanced technologies to enhance opera...
Reposted 3 days ago
$150K - $180K *
Accelerate growth by leading global partnerships with PwC and GSIs. Drive revenue through strategic relationship management, co-selling initiatives, and market expansion while collaborating with cross...
3 days ago
Senior Business Applications Engineer
$150K - $200K *
Lead the charge in transforming business challenges into innovative solutions by leveraging your expertise in automation and integration. Collaborate across teams to enhance operational efficiency and...
3 days ago
Senior Manager, Finance Analytics
$175K - $185K *
Join a team that's redefining finance analytics by leading strategic forecasting and performance management. Drive impactful financial insights and methodologies while collaborating with leadership to...
3 days ago
Associate Director, Paid Social
$96K - $135K *
Elevate your career as a strategic leader in paid social, driving growth through innovative strategies and high-performing teams. Leverage your expertise to optimize complex campaigns and foster colla...
3 days ago
$98K - $126K *
Empower customer success by managing renewals, driving growth, and mitigating risks. Collaborate with cross-functional teams to enhance client relationships and ensure satisfaction while maximizing co...
3 days ago
Senior Tax Associate, Indirect Sales and Use
$85K - $100K *
Join a team that's dedicated to delivering exceptional indirect tax solutions. You'll manage compliance, conduct research, and collaborate with clients across multiple jurisdictions, enhancing their t...
3 days ago
Renewables Civil Designer-BESS
$79K - $107K *
Join a team that's redefining energy solutions by designing innovative Battery Energy Storage Systems. Collaborate with engineers to deliver impactful civil designs that enhance land development proje...
3 days ago
Strategy & Operations Senior Manager (Security and Technology)
$200K - $235K *
Empower organizational strategy and execution in Security & Technology, driving cross-functional initiatives and enhancing communication. Collaborate with leadership to optimize operations and inspire...
3 days ago
$199K - $274K *
Transform enterprise-scale engineering capabilities by leading the TORC function, fostering collaboration across security and operations, and delivering innovative solutions for risk and control manag...
3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.