Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Plant Process Simulation Engineer II
$115K - $150K *
Join a team that's dedicated to advancing clean energy by developing and owning plant process simulation models. Collaborate across disciplines to enhance design, operations, and plant dynamics for in...
3 days ago
Staff Data Engineer, Core Migrations
$230K - $260K *
Lead the charge in client migrations, owning the entire technical lifecycle from legacy analysis to deployment, ensuring precision and collaboration across teams for optimal outcomes...
Reposted 3 days ago
Associate Director, Access Strategy and Marketing
$177K - $221K *
Manage the strategy and execution of access marketing for oncology products, focusing on value propositions for payers and healthcare providers. Collaborate with cross-functional teams to ensure effec...
3 days ago
Associate Director, Field Reimbursement
$211K - $235K *
Drive patient access initiatives by leveraging oncology expertise to navigate reimbursement landscapes, educate stakeholders, and resolve complex access issues, ensuring timely therapy access for pati...
3 days ago
Territory Sales Representative, Implants MIS
$82K - $150K *
Elevate your career by driving growth in the dental implant market. This role focuses on acquiring new customers, expanding market share, and positioning value-driven solutions, requiring a proactive...
Reposted 3 days ago
Territory Sales Representative, Essential Dentistry
$70K - $120K *
Drive sales success by building relationships with dental professionals, promoting innovative products, and achieving targets. Leverage your expertise to deliver exceptional customer service and suppo...
Reposted 3 days ago
$151K - $203K *
Shape the future of marketing by building systems that unify messaging, drive growth, and enhance customer engagement across departments. Collaborate with teams to create impactful strategies that sup...
3 days ago
$95K - $115K *
Champion project delivery by overseeing HV cable testing projects across North America. Ensure alignment with client expectations while managing resources, schedules, and budgets for successful comple...
Reposted 3 days ago
Senior Engineering Manager - Developer Platform (DevEx)
$157K - $224K *
Champion the evolution of developer tooling and CI/CD pipelines, leading a global team to enhance operational efficiency and drive platform modernization for a multi-tenant SaaS environment, ensuring...
3 days ago
$74K - $114K *
Innovate solutions in manufacturing by developing methods and tooling to enhance production efficiency. Collaborate with teams to implement Lean Principles and drive continuous improvement in a dynami...
3 days ago
Sr. Account Manager, Industrial Water, NA
$120K - $140K *
Shape the future of industrial water solutions by driving sales growth, managing key accounts, and fostering enduring partnerships with customers and teams to enhance sustainable business outcomes and...
Reposted 3 days ago
$80K - $100K *
Unlock potential by leading accurate project estimates in commercial construction. Collaborate with teams to deliver competitive bids and enhance project outcomes while developing your skills in a dyn...
3 days ago
$110K - $130K *
Lead supplier quality initiatives to ensure product conformity and drive continuous improvement. Collaborate with cross-functional teams to establish quality standards, manage audits, and enhance supp...
Reposted 3 days ago
Incident Response Sr. Consultant (Remote)
$115K - $160K *
Join a team that's dedicated to enhancing global security through advanced incident response and forensic analysis. Collaborate with top professionals to protect organizations from sophisticated threa...
3 days ago
Application Services (AMS) Specialized Sales Executive -Digital Sales
$125K - $150K *
Join a team that's driving digital transformation by spearheading sales in Application Modernization Services, leveraging AI trends to cultivate strategic client relationships and optimize business gr...
Reposted 3 days ago
$75K - $90K *
Transform financial insights into strategic initiatives, supporting planning and analysis as the organization scales. Collaborate across teams to enhance budget management, reporting, and performance...
Reposted 3 days ago
Sr. Manager, Sales Performance
$102K - $141K *
Join a team that's dedicated to enhancing sales performance through strategic process development, technology alignment, and targeted training. Collaborate with cross-functional teams to drive effecti...
3 days ago
$80K - $95K *
Engage in comprehensive assessments of building performance and energy efficiency. Collaborate with clients to enhance sustainability practices while reducing operational costs through detailed audits...
Reposted 3 days ago
Technical Report Reviewer (HUD)
$85K - $102K *
Elevate your career by reviewing and editing environmental and property assessments. Collaborate with field staff to ensure report accuracy and quality, while providing technical guidance and maintain...
Reposted 3 days ago
Electrical Manager HV - 100% Travel
$100K - $120K *
Take ownership of electrical project coordination on utility-scale solar sites. Ensure high-quality installations, manage contractor relationships, and maintain safety and efficiency standards while t...
Reposted 3 days ago
Senior Electrical Engineer (Renewable Energy) - REMOTE
$140K - $200K *
Optimize project outcomes by leading comprehensive electrical design reviews in renewable energy sectors. Ensure compliance with industry standards while effectively managing timelines and costs for d...
Reposted 3 days ago
$135K - $140K *
Advance your career by driving full-cycle recruitment for diverse Sales and Go-To-Market roles. Collaborate with leadership to attract top talent, enhance candidate experience, and optimize hiring pro...
3 days ago
Infrastructure Security Vulnerability Engineer
$127K - $133K *
Elevate your career by managing vulnerability remediation in cloud environments. Collaborate with technical teams to analyze security risks, prioritize vulnerabilities, and implement effective solutio...
Reposted 3 days ago
Senior Manager, Cloud Infrastructure
$170K - $190K *
Lead and innovate within UJET's Core Infrastructure team, focusing on cloud-native services. Shape strategies for scalable solutions that empower engineers and optimize the infrastructure for thousand...
Reposted 3 days ago
Manager, Regional Sales - Glaucoma - West Coast
$160K - $200K *
Transform regional performance by leading a high-performing sales team, driving market adoption, and executing strategic initiatives in the ophthalmic surgical industry to achieve commercial success a...
Reposted 3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.