Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Lead Partner Marketing Specialist
$95K - $115K *
Champion partner-led demand generation by developing and executing scalable marketing strategies. Collaborate with sales and marketing teams to drive pipeline growth and optimize performance across ke...
3 days ago
E-EFMP Software Product Management Lead
$120K - $145K *
Shape the future of enterprise software by leading product strategy, design, and delivery for impactful applications supporting federal missions. Collaborate across multifunctional teams to ensure sec...
Reposted 3 days ago
$85K - $130K *
Champion innovative control systems for industrial solutions, leading design and development projects. Collaborate with teams to ensure products meet market demands while transitioning designs to manu...
3 days ago
$110K - $130K *
Empower a team of controls engineers to design and enhance control systems for material handling solutions, ensuring project execution and quality while fostering innovation and collaboration across d...
3 days ago
Manager Accounting - Financial Reporting
$125K - $145K *
Champion the future of financial reporting by ensuring compliance with GAAP, overseeing audits, and mentoring a high-performing team. Drive process improvements and technical accounting expertise to e...
3 days ago
DRG Validation Auditor - Off Hours Work (2nd, 3rd, or weekend shift work)
$95K *
Lead the charge in auditing inpatient claims, ensuring coding accuracy and clinical validation. Utilize advanced coding expertise to analyze claims independently, while meeting productivity and qualit...
3 days ago
$80K - $95K *
Engage with patients as a Virtually Integrated Care RN, providing essential remote support and care coordination. Utilize advanced clinical skills to assess needs, develop care plans, and enhance pati...
3 days ago
Associate Director, Innovation Strategy and Execution
$110K - $130K *
Optimize the Innovation portfolio by leading high-impact projects, collaborating with senior leaders, and driving strategic initiatives. Your role will ensure seamless operations and foster growth in...
3 days ago
Technical Project Manager / Scrum Master
$90K - $140K *
Join a dynamic team to lead complex data management projects, blending Agile methodologies with technical expertise. Drive collaboration across healthcare analytics, ensuring successful delivery and s...
3 days ago
$150K - $180K *
Lead a high-performing sales team to drive new logo acquisition and revenue growth in enterprise software. Develop strategies, foster collaboration, and engage executive customers to expand market sha...
3 days ago
ServiceNow Technical Project Manager
$110K - $130K *
Lead the transformation of healthcare IT by managing ServiceNow projects, enhancing workflows, and ensuring seamless integration. Collaborate with cross-functional teams to deliver innovative solution...
3 days ago
Complex Claim Specialist, Legal Malpractice
$120K - $175K *
Join a team that's dedicated to managing complex professional liability claims, focusing on legal malpractice. Leverage your expertise to evaluate coverage, negotiate outcomes, and ensure timely reser...
3 days ago
Senior Growth Marketing Manager, Consumer
$126K - $236K *
Lead the charge in consumer engagement and growth strategy, driving awareness and deepening user connections across channels. Collaborate cross-functionally to optimize campaigns that inspire action a...
3 days ago
Senior AI Engineer, Platform Integration
$135K - $175K *
Drive the integration of AI tools into a secure cloud platform for capital markets, ensuring compliance and security while collaborating with top law firms and engineering teams to enhance document wo...
3 days ago
Enterprise Business Development Manager
$90K - $110K *
Join a team that's driving enterprise growth by building relationships and closing new business. This proactive sales role focuses on acquiring customers for innovative workforce development solutions...
3 days ago
$275K - $340K *
Drive growth by leading sales and customer success teams, refining strategies, and optimizing processes. Shape the commercial landscape while mentoring talent and ensuring high-value customer relation...
3 days ago
Director, Copay & Affordability
$199K - $269K *
Shape patient affordability strategies by leading a dynamic team focused on co-pay programs and innovative solutions. Collaborate cross-functionally to enhance operations, optimize performance, and dr...
Reposted 3 days ago
Director Global Safety- Global Periodic Aggregate Safety Reports
$191K - $258K *
Shape the future of global safety by leading the development and submission of periodic aggregate safety reports. Drive compliance and collaboration across teams while managing a diverse global team t...
3 days ago
$85K - $100K *
Deliver advanced field service support for Promega instrumentation, ensuring installation, training, and repairs meet customer service standards. Collaborate with teams to enhance service documentatio...
3 days ago
Senior Director of Design, Search & Feeds
$317K - $443K *
Engage with cross-functional teams to shape the design vision for search and feeds, leading a talented design group to enhance user discovery and community connections while driving growth and retenti...
3 days ago
$80K - $95K *
Join a team that's dedicated to enhancing automation solutions through troubleshooting, programming, and customer collaboration. Leverage your skills to improve machinery performance and ensure seamle...
Reposted 3 days ago
National Account Director, Community Oncology
$245K - $290K *
Champion strategic relationships in community oncology to enhance market access for innovative therapies. Drive account strategies, negotiate contracts, and collaborate cross-functionally to ensure op...
3 days ago
Sales Solutions Engineer - 1079
$80K - $95K *
Shape the future of client solutions by leading technical discovery and crafting innovative data-driven strategies. Collaborate with sales teams to drive success and ensure seamless implementation of...
3 days ago
AI Deployment Engineer/Manager
$80K - $95K *
Champion the deployment of cutting-edge AI systems in diverse environments. Collaborate with teams to ensure seamless installation and operation of hardware and software, while providing exceptional c...
3 days ago
Supervisory Pharmacist (Clinical)
$100K - $120K *
Elevate pharmacy operations by leading strategic initiatives, ensuring compliance, and managing a skilled team to deliver exceptional patient care and medication management services in a dynamic healt...
Reposted 3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.