Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$123K - $145K *

Optimize product launches by collaborating cross-functionally to ensure timely delivery and high quality. Leverage engineering expertise to manage complex programs, drive continuous improvement, and e...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$116K - $149K *

Manage strategic growth initiatives for digital solutions in commercial markets. Collaborate with cross-functional teams to drive customer adoption, enhance operational performance, and achieve revenu...

United StatesRemote

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  •   5 - 7 years exp.  •   Manufacturing & Automotive

$162K - $292K *

Join a team that's redefining identity operations by leading a 24/7 team to enhance access management strategies. You'll shape the vision, drive process innovation, and foster talent in a collaborativ...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$198K - $298K *

Lead the charge in shaping the AMER Revenue Operations strategy, driving operational excellence and predictable outcomes. Collaborate with executive leadership to optimize sales processes and build a...

United StatesRemote

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  •   11 - 15 years exp.  •   Enterprise Technology

$160K - $220K *

Champion the design and architecture of data systems, driving innovation and collaboration across teams to enhance user experiences and optimize data management for MyFitnessPal's ecosystem...

United StatesRemote

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  •   8 - 10 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Transform customer experiences by driving satisfaction and growth through strategic partnerships. Leverage your L&D expertise to enhance client engagement and ensure program success while collaboratin...

United StatesRemote

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  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $110K *

Elevate your career by leading impactful fundraising communications and events. Drive donor engagement through compelling storytelling and strategic initiatives while managing a diverse portfolio in a...

United StatesRemote

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  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$180K - $200K *

Transform our data landscape by leading the end-to-end data platform, modernizing architecture, and empowering analytics teams to deliver trusted insights across the organization. Drive innovation wit...

United StatesRemote

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  •   5 - 7 years exp.  •   Hospitality & Recreation

$130K - $160K *

Transform the user experience and operational workflows in a complex two-sided marketplace. Lead product initiatives that enhance clinician and district interactions, streamline processes, and drive i...

United StatesRemote

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  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$175K - $236K *

Champion quality excellence by leading a dynamic team to enhance compliance and drive continuous improvement in clinical development. Collaborate across functions to ensure regulatory readiness and de...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$197K - $328K *

Shape the future of pharmacy network operations by leading a team of attorneys, providing strategic legal counsel on regulatory, operational, and transactional matters within the PBM landscape, while...

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Reposted today

  •   8 - 10 years exp.  •   Healthcare

$110K - $150K *

Transform student engagement by developing impactful marketing campaigns and community initiatives across partner campuses. Drive enrollment and retention through strategic partnerships, innovative ou...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$194K - $242K *

Unlock potential by leading product marketing strategies in GLP-1 and cardiometabolic health. Collaborate with cross-functional teams to enhance buyer clarity and sales effectiveness, while coaching a...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Lead cloud architecture and platform engineering, balancing strategic vision with hands-on technical execution. Drive team growth, ensure compliance, and enhance infrastructure for secure healthcare s...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Join us to drive growth in enterprise accounts, owning the full sales cycle from prospecting to closing. Collaborate with a dynamic team to convert leads into revenue while leveraging market insights...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$114K - $186K *

Drive strategic enterprise growth by guiding large organizations through their DevSecOps transformation, ensuring successful adoption and long-term value from GitLab's AI-powered platform while managi...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$140K - $170K *

Join a dynamic team to optimize operational systems, drive growth, and enhance performance across departments. Collaborate with leadership to ensure strategic goals translate into measurable results a...

United StatesRemote

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  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Engage in designing and implementing SAP Plant Maintenance solutions for complex federal projects. Collaborate with stakeholders to enhance asset management efficiency and ensure seamless integration...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$139K - $235K *

Transform customer infrastructure management by owning the product vision and roadmap for a key control plane. Collaborate with engineering to enhance user experience and operational efficiency, drivi...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Join a dynamic team to design and implement APIs and integrations using MuleSoft for complex SAP S/4HANA projects, enhancing data flow across critical systems for federal clients, including the U.S. N...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$135K - $200K *

Pioneer the future of eCommerce by owning product strategy and execution. Collaborate with cross-functional teams to leverage AI tools, drive innovation, and enhance client experiences in a fast-paced...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's driving strategic growth by deepening executive relationships and expanding our platform's impact across high-value customer accounts. Collaborate with cross-functional teams to sol...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$100K - $160K *

Elevate your career by driving strategic growth initiatives across multiple states. Collaborate with diverse teams to enhance market share and develop agency capabilities, focusing on future revenue g...

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  •   5 - 7 years exp.  •   Manufacturing & Automotive

$170K - $230K *

Engineer the future of edge-AI by converting customer evaluations into design wins. Collaborate with engineering teams to optimize workloads on our innovative Chimera architecture, shaping the next ge...

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Reposted today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $140K *

Join a team that's driving growth in unstructured data protection. Leverage your technical expertise to engage with clients, lead discovery, and close deals while collaborating with sales and engineer...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.