Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$150K - $180K *

Shape the future of AI evaluation by leading rigorous methodologies, collaborating with engineers, and mentoring teams to ensure accurate assessments that drive product innovation and market standards...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $190K *

Transform user engagement by owning product roadmaps, collaborating cross-functionally, and leveraging data to drive impactful solutions. Engage with customers to identify opportunities and validate h...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $112K *

Join a team that's redefining accounting operations. You'll manage day-to-day accounting, ensure accurate financial reporting, and collaborate closely with leadership to enhance processes as we grow...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $189K *

Lead the charge in developing and executing innovative marketing strategies for oncology products, collaborating with cross-functional teams to ensure successful launches and impactful customer engage...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$122K - $160K *

Transform the future of endpoint management by developing innovative solutions that enhance security and performance across diverse platforms, collaborating with a dynamic team to deliver impactful so...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Information Technology

$82K - $150K *

Lead the charge in expanding market presence by driving new customer acquisition and maximizing share of wallet within the dental implant community. Utilize a hunter mentality to identify opportunitie...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $150K *

Accelerate growth by driving new customer acquisition and expanding market share in the dental implant sector. Leverage a hunter mentality to convert competitive accounts and position value-oriented s...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$117K - $158K *

Unlock the potential of digital workspaces by leading VDI and EUC services opportunities. Collaborate with cross-functional teams to design, scope, and deliver innovative solutions that enhance user e...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$117K - $158K *

Unlock potential by shaping and delivering AV and meeting room solutions at scale. This role combines technical expertise with project ownership, guiding clients from discovery to implementation while...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Unlock potential by driving territory growth through strategic sales and account management. Collaborate with healthcare professionals to enhance customer experience and position as a leader in tumor...

South Dakota, USRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Join a team that's redefining product marketing in B2B SaaS. Collaborate closely with sales and product teams to craft compelling narratives, build essential sales tools, and drive successful product...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$180K - $220K *

Drive the engineering vision for innovative nuclear technology, leading a multi-disciplinary team to ensure successful design, execution, and regulatory compliance for groundbreaking reactor systems d...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Energy & Utilities

$80K - $115K *

Optimize client success by managing relationships, driving renewals, and aligning technology with client needs. Collaborate with cross-functional teams to deliver impactful solutions and ensure long-t...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Media

$250K - $500K *

Champion innovation by leading the migration to EKS, optimizing cloud infrastructure, and enhancing Kubernetes operations. Drive automation and CI/CD processes while ensuring high availability and per...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$123K - $160K *

Champion innovative cancer therapies by leading quality operations for apheresis and treatment centers. Collaborate cross-functionally to ensure compliance and support Kite's rapid expansion in CAR-T...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Explore an impactful leadership role driving sales strategies and team development in the PAH marketplace. Collaborate with cross-functional teams to enhance performance and foster relationships with...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$113K - $160K *

Champion the quantification of business impact from technology and transformation investments. Lead financial modeling and value realization efforts, translating insights into actionable recommendatio...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Media

$80K - $95K *

Reimagine operational excellence by leading a regional team to optimize performance, enhance customer satisfaction, and ensure compliance. Drive financial success while fostering a safe and efficient...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Transportation

$113K - $188K *

Shape the future of managed care by leading contract negotiations, performance monitoring, and strategic initiatives to optimize reimbursement and enhance payer relationships across healthcare service...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

$90K - $120K *

Drive financial excellence by collaborating across teams to enhance planning and reporting processes. This role blends detailed analysis with strategic insight, offering visibility into key leadership...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$250K - $275K *

Champion partner engagement and drive revenue growth by managing established channel relationships. Leverage your expertise in Telecommunications and Unified Communications to enhance partner success...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$95K - $115K *

Transform safety standards across diverse US field operations. Lead, coach, and implement effective safety programs while ensuring compliance and risk management in complex environments. Drive account...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$70K - $100K *

Join a dynamic team to drive profitable business through strategic underwriting and broker partnerships. Leverage your expertise to enhance client relationships and contribute to innovative solutions...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Unlock your potential as a Product Manager, driving product health and outcomes through strategic decision-making, collaboration, and customer insights across the product lifecycle. Shape the future o...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$160K - $180K *

Unlock potential by leading creative engagements across healthcare accounts. Drive innovative campaigns, mentor teams, and manage client relationships while delivering impactful narratives that resona...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.