Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$230K - $260K *

Join us to lead a regional sales team, driving strategic initiatives and fostering relationships to achieve business objectives while enhancing patient outcomes in the oncology sector...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$99K - $169K *

Unlock potential by providing expert consulting on accounting methods, managing client projects, and developing staff. Collaborate with internal and external clients while staying updated on tax regul...

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $130K *

Champion seamless technical integrations by leading end-to-end delivery, troubleshooting, and documentation. Collaborate with customer IT teams to ensure compliance and optimize data flows in a dynami...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Champion global physical security and resiliency initiatives by providing strategic leadership to enhance safety for employees and assets while driving compliance across all company operations and thi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $170K *

Shape the future of enterprise infrastructure by leading design, implementation, and optimization of systems. Drive automation, enhance security, and mentor junior staff while collaborating on strateg...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$285K - $335K *

Lead the charge in developing and executing commercial strategies that drive brand growth and enhance decision-making capabilities across a dynamic portfolio, focusing on oncology and market insights...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$165K - $175K *

Drive the strategic execution of an enterprise data governance program, shaping policies and fostering collaboration among stakeholders to enhance data quality and compliance across the organization...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$157K - $283K *

Lead the charge in driving business growth by developing strategic partnerships and innovative solutions for federal clients, while collaborating with cross-functional teams to deliver exceptional res...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$120K - $322K *

Provide comprehensive medical care and consultation for incarcerated patients, ensuring quality treatment through interdisciplinary collaboration and emergency response while maintaining compliance wi...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Lead the charge in building strategic partnerships that drive revenue and growth. Collaborate across teams to identify opportunities, negotiate agreements, and create impactful integrations that enhan...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $200K *

Drive account growth by managing client relationships and fostering strategic partnerships. This dynamic role engages with clients, executing sales strategies to expand product adoption while ensuring...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$183K - $220K *

Lead strategic initiatives for Integrated Delivery Networks and health systems, optimizing patient access and formulary adoption. Build executive relationships and drive clinical integration to enhanc...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Lead the charge in providing medical oversight for clinical studies, ensuring compliance with regulations and delivering expert training. Collaborate with teams to enhance drug safety and therapeutic...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$250K - $275K *

Join us to lead clinical operations for a multi-state virtual care team, ensuring high-quality, timely care. This role combines direct patient care, administrative leadership, and strategic oversight...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$88K - $125K *

Unlock potential by leveraging advanced analytics and consultative skills to drive client success in the Consumer Healthcare vitamins sector. Collaborate cross-functionally to deliver insights and fos...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$70K - $90K *

Empower clients by managing habitational commercial insurance accounts, fostering relationships, and ensuring seamless service delivery. Collaborate with team members to strategize on complex coverage...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$170K - $200K *

Elevate tax administration services for exchange-traded funds by leading a dynamic team, resolving complex tax matters, and enhancing processes to support a growing fund platform while ensuring compli...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Join a team that's dedicated to enhancing client relationships and driving success. Oversee client performance, mentor staff, and ensure compliance while collaborating with various departments to deli...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Elevate your career by leading strategic product initiatives in retirement solutions. Drive innovation, market insights, and cross-functional collaboration to enhance the core advice business and achi...

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $175K *

Drive your career forward by leading new logo acquisition with AI/ML teams. Own the sales cycle, build consensus across stakeholders, and deliver accurate forecasting while connecting AI products to g...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Drive impactful data analysis and risk management for global clinical trials, interpreting complex data to identify trends and risks. Lead cross-functional teams in enhancing study quality and patient...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Staffing

$83K - $147K *

Join a team that's shaping the future of sales training by architecting and delivering innovative programs for agents. Collaborate with leaders to enhance strategies, improve performance, and drive ex...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$73K - $99K *

Take ownership of financial oversight and reporting for private debt funds, collaborating with diverse teams to enhance fund accounting, investor reporting, and audits, while gaining insights into com...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$62K - $112K *

Transform member engagement by proactively addressing concerns, coordinating solutions, and enhancing satisfaction. Collaborate with cross-functional teams to drive improvements and ensure a seamless...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Transportation

$110K - $130K *

Champion data-driven decision-making by transforming insights into actionable reports and dashboards. Collaborate with cross-functional teams to enhance performance, optimize strategies, and drive bus...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.