Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$229K - $310K *

Drive project management and business development to enhance operational efficiency in life sciences R&D, while leading diverse teams and ensuring profitability through strategic customer engagement a...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $158K *

Transform the Property Intelligence platform by connecting customer needs with product insights. Collaborate across teams to enhance product adoption and engagement through analytics and feedback, dri...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$86K - $129K *

Inspire a high-performing claims team by managing investigations, settlements, and compliance. Drive operational excellence while fostering staff development and effective communication to achieve bus...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$75K - $126K *

Innovate with us to enhance network security platforms, ensuring robust protection and operational efficiency. As a key engineer, you'll tackle complex challenges, automate processes, and collaborate...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $180K *

Transform global partner strategies to drive revenue and market share through innovative go-to-market models, collaborating with key stakeholders to establish impactful partnerships and optimize sales...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$69K - $109K *

Transform operational initiatives by leading complex projects, ensuring compliance, and collaborating with stakeholders to enhance investment data integrity and drive strategic solutions in a dynamic...

Des Moines, IARemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$65K - $108K *

Optimize project delivery by coordinating Agile activities and enhancing contract management processes. Collaborate with federal stakeholders to track progress, manage risks, and ensure effective comm...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

$175K - $210K *

Drive the execution of a comprehensive medical affairs plan for prostate cancer theranostics, collaborating across functions to enhance strategy, launch readiness, and lifecycle planning while advanci...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $237K *

Champion enterprise-wide legal affairs and compliance strategies, ensuring operational integrity and ethical governance. Collaborate with county officials to manage risk, personnel administration, and...

Today

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$75K - $90K *

Grow your career with a dynamic role focused on generating new loan opportunities, building strong relationships, and managing a robust pipeline to meet production targets while delivering tailored fi...

Des Moines, IARemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$78K - $88K *

Join us to perform actuarial analyses and support healthcare consulting projects. Collaborate with multidisciplinary teams to develop insights, maintain models, and communicate findings effectively wh...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$150K - $220K *

Oversee a specialized team to ensure AI safety in biological research, addressing dual-use risks and providing expert guidance on complex cases while mentoring junior specialists and advising clients...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$145K *

Drive innovation and transform lives by leading regulatory strategies and submissions for clinical trials globally. Act as a key liaison for project teams to ensure compliance, operational excellence...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$217K - $271K *

Launch your career by owning the national Field Excellence model, managing operations for a groundbreaking oncology therapy. Collaborate with sales leaders to enhance prescriber access and streamline...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$101K - $154K *

Shape the future of enterprise partnerships by driving value through collaboration with Sales, Product, and Marketing teams. Leverage your expertise to identify ROI opportunities and enhance customer...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$104K - $153K *

Unlock your potential by leading the technical delivery of workforce applications. Collaborate with teams to enhance productivity through automation, AI, and integrations, ensuring secure and efficien...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Drive customer success by managing enterprise accounts, ensuring retention and growth through strategic partnerships and data-driven insights. Collaborate cross-functionally to enhance customer experi...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $200K *

Lead the charge in strategic client services management, overseeing growth, engagement, and high-value account portfolio. Drive team performance and build enduring client relationships that enhance bu...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$103K - $161K *

Drive strategic growth by establishing and nurturing key partnerships with Enterprise Claims carriers, ensuring service excellence and collaboration across internal teams to enhance business outcomes...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $120K *

Drive revenue growth by leading high-performing sales teams and executing strategic sales initiatives. This role combines leadership with deep expertise in performance marketing to achieve ambitious b...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$110K - $130K *

Champion strategic alliances to drive growth, enhance partnerships, and align cross-functional teams. Lead initiatives that translate company goals into actionable plans, ensuring measurable results a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $130K *

Lead complex projects to successful completion by developing integrated plans, managing risks, and aligning stakeholders across business and technology teams to ensure effective execution and continuo...

Des Moines, IARemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Optimize clinical trial operations by leading cross-functional teams, managing vendor relationships, and ensuring compliance with regulatory standards to drive successful study execution and patient e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $160K *

Join a team that's committed to enhancing our cybersecurity and GRC programs. You'll drive initiatives across risk management, compliance, and operational security, playing a vital role in strengtheni...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$92K - $166K *

Join a dynamic team to enhance the FAA's Fire Life Safety Program, ensuring compliance and safety across various facilities. Leverage your expertise in fire protection engineering to support policy de...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.