Grasp unique opportunities in the scientific realm by exploring high-paying Principal Scientist jobs that offer annual remuneration of over $100,000. Broaden your professional horizons and get closer to your career goals with our advanced search tools for Principal Scientists.
As a Principal Scientist, you will lead innovation, drive scientific research, and contribute to the growth of the scientific community at large. It is a role that combines leadership, in-depth scientific knowledge, and impactful decision-making.
We provide comprehensive job listings, insightful articles, growth opportunities, and a diverse range of resources for Principal Scientists looking to make their next career move.
$140K - $170K *
Champion innovative pharmacology studies to drive anti-infective drug development. Leverage expertise in both in vitro and in vivo models to guide project strategy, collaborating across teams and ensu...
1 week ago
Senior Scientist - Assay Development
$138K - $190K *
Optimize cancer diagnostics by developing innovative automated assays in a cross-functional team, enhancing molecular biology workflows, and leading studies for early cancer detection...
2 weeks ago
$110K - $150K *
Elevate product innovation by leading cross-functional teams to develop and execute a multiyear roadmap of over-the-counter and cosmetic topical products that meet consumer needs and business objectiv...
4 days ago
$100K - $120K *
Join a team that's dedicated to ensuring quality assurance in national security lab programs. Leverage your analytical chemistry expertise to support audit preparation, proficiency testing, and compli...
1 week ago
Senior Scientist, R&D Design Transfer & Product Development
$115K - $144K *
Champion the transition of IVD Next-Generation Sequencing assays from R&D to Operations while ensuring compliance with quality standards, collaborating across functions to drive project completion in...
Reposted 6 days ago
$88K - $105K *
Optimize analytical methods and provide robust support for drug substance testing, independently organizing work, evaluating data, and ensuring compliance with regulatory standards while engaging with...
Reposted 4 days ago
Drug Discovery Scientist & Engineer
$110K - $130K *
Shape the future of drug discovery by leveraging your preclinical expertise to develop innovative software solutions. Collaborate with engineers and domain experts to enhance scientific workflows and...
4 weeks ago
Senior Scientist II, Biophysics and Protein Sciences
$170K - $212K *
Join a dynamic team of biophysicists to accelerate drug discovery through innovative biophysical methods, enhancing target validation, and mechanistic insights for oncology projects while collaboratin...
3 weeks ago
Senior Scientist – Quality Control
$95K - $100K *
Elevate your career as a Sr. Scientist in Quality Control, applying your expertise in lab sciences and compliance to drive methodologies, testing and continuous improvements in a dynamic laboratory en...
1 week ago
Senior Manager, Materials Science
$150K - $180K *
Pioneer innovative approaches in materials diagnostics and interactions, leading R&D efforts for extreme environments. Collaborate with experts to develop and implement strategies that enhance materia...
Reposted 2 weeks ago
$80K - $95K *
Empower your career by leading engineering and validation projects in GMP-regulated environments, ensuring operational readiness and compliance while coordinating cross-functional teams for successful...
1 week ago
Process Development Senior Principal Scientist Bioconjugates
$157K - $213K *
Transform bioconjugate manufacturing by leading innovative processes and multidisciplinary teams. Drive scientific excellence and mentor future leaders in the pursuit of sustainable and effective drug...
5 days ago
Sr. Principal Scientist (Sr. Director) - Regulatory Liaison
$190K - $300K *
Unlock potential by leading global regulatory strategies in cardiovascular and metabolic programs. Collaborate with cross-functional teams to ensure timely drug approvals while managing complex projec...
Reposted 3 weeks ago
Sr. Principal Scientist (Sr. Director) - Regulatory Liaison
$190K - $300K *
Redefine global regulatory strategy by leading complex cardiovascular programs, driving optimal results with minimal oversight while engaging with global regulatory agencies for timely approvals and c...
Reposted 3 weeks ago
Sr. Principal Scientist (Sr. Director) - Regulatory Liaison
$190K - $300K *
Lead the charge in global regulatory strategy development for innovative cardiovascular programs, ensuring efficient approval processes and strategic oversight to accelerate drug advancements through...
Reposted 3 weeks ago
Sr. Principal Scientist (Sr. Director) - Regulatory Liaison
$190K - $300K *
Unlock your potential as a strategic leader in global regulatory affairs, driving innovative cardiovascular solutions and ensuring rapid approval processes while managing complex development programs...
Reposted 3 weeks ago
Manager/Principal Scientist Research & Development - Polymer Formulation
$130K - $180K *
Join a dynamic team as a leader driving innovation in polymer formulation for medical devices. You'll oversee projects from concept to manufacturing, ensuring regulatory compliance while mentoring tal...
1 week ago
Scientist III, Protein Purification
$83K - $100K *
Join a dynamic team dedicated to protein purification, employing advanced techniques and equipment in a collaborative laboratory environment. Contribute as a technical expert while ensuring high-quali...
2 weeks ago
Sr. Scientist I/Sr. Scientist II, Applied AI & Agentic Systems for Drug Discovery
$160K - $220K *
Collaborate with cross-functional teams to develop and deploy LLM-driven agents that enhance scientific workflows, ensuring efficient decision-making in drug discovery processes...
3 weeks ago
Principal Research Engineer/Scientist
$125K - $150K *
Drive groundbreaking research initiatives to enhance enterprise agentic AI, focusing on tacit knowledge accumulation, continuous learning, resilience, safety, and data privacy within real operational...
1 week ago
Chemical Reactivity Landscape, Scientific Project Leader
$177K - $308K *
Drive scientific leadership at the nexus of quantum chemistry, ML, and HTE. Direct initiatives that bridge predictions and experimental outcomes, fostering innovation in reaction discovery through tea...
4 days ago
Sr. Scientist, Downstream and Biologics Formulation Development
$147K - $184K *
Lead biologics formulation and downstream process development, driving innovation and strategy in a collaborative, fast-paced environment. Engage with cross-functional teams and mentor junior staff wh...
Reposted 3 days ago
Director of Formulation Chemistry
$150K - $180K *
Tackle the transformation of innovative compounds into scalable solutions. Drive experimental design and optimization, ensuring consistent results in manufacturing processes. Collaborate across teams...
3 days ago
Business Operations, Product & Science
$250K - $300K *
Shape the future of scientific innovation by leading operational strategies that bridge AI and physical sciences. Drive cross-functional coordination, enhance research visibility, and partner with lea...
Reposted 3 weeks ago
Principal Scientist, Chemical Development
$169K - $206K *
Join a team that's advancing innovative cancer therapies. Lead the development of transformative small molecule processes while collaborating cross-functionally, shaping drug development strategies, a...
3 weeks ago
What is the role of a Principal Scientist?
A Principal Scientist typically leads scientific research, explores innovative ideas, and guides a team of scientists towards achieving the organization's scientific goals.
How much does a Principal Scientist earn on average?
The average salary of a Principal Scientist varies depending on the industry and level of experience. However, on Ladders, you can find Principal Scientists jobs that pay over $100,000.
What qualifications are required for Principal Scientist jobs?
Most Principal Scientist roles require at least a Ph.D. in a relevant scientific field along with several years of research experience. Leadership skills and a proven research track record are typically also essential.
Can I find remote Principal Scientist jobs on Ladders?
Yes, on Ladders, you can find both remote and in-office high-paying Principal Scientist jobs.