Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$160K - $190K *

Shape the future of anesthetic care by collaborating with a dedicated team to provide safe, patient-focused services. Your expertise will drive quality outcomes in a supportive environment that champi...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$180K - $215K *

Drive regional sales success by leading a high-performing team, executing launch strategies, and fostering customer relationships to achieve business objectives in a dynamic environment...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$82K - $182K *

Develop and maintain QuickBase applications while leading complex analytics projects. Ensure data integrity and support clinical performance reporting. Collaborate with stakeholders to drive continuou...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$190K - $230K *

Lead the accounting and financial reporting functions within a growing healthcare organization. Drive integrity across multiple entities, ensure compliance, and strategize cash management while suppor...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Healthcare

$80K - $145K *

Unlock potential by driving strategic government relations across the Midwest. Build and maintain key relationships with legislators and stakeholders to ensure Covista's success in navigating the legi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$138K - $150K *

Analyze and manage corporate portfolio growth through strategic projects and business development. Collaborate with cross-functional teams to drive M&A initiatives and evaluate market opportunities, e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$138K - $150K *

Accelerate progress at a leading firm by managing corporate portfolio growth through strategic projects and business development in digital health and emerging technologies. Collaborate with managemen...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a dynamic team to develop and deliver clinical training programs, ensuring high-quality education for partners and stakeholders. Act as a subject-matter expert while fostering relationships to en...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$70K - $99K *

Join a team that's dedicated to providing exceptional nursing care to residents. Utilize your expertise in assessment, planning, and implementation to enhance patient outcomes in a supportive long-ter...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K *

Champion the clinical operations team, ensuring project success through resource management, process efficiencies, and compliance. Drive training, metrics development, and mentorship to enhance team c...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $120K *

Champion the development of high-quality program materials and deliverables, enhancing effectiveness in complex specialty markets. Collaborate with teams to ensure project success through strong manag...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Champion global physical security and resiliency initiatives by providing strategic leadership to enhance safety for employees and assets while driving compliance across all company operations and thi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Inspire growth by leading regional launch strategies and building high-performing sales teams. Drive market success through strong customer relationships and cross-functional collaboration in a fast-p...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Champion the execution of a comprehensive medical affairs plan for renal cancer theranostics, driving cross-functional alignment and strategic initiatives to enhance patient outcomes and advance clini...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$79K - $127K *

Unlock insights into medical cost trends by leveraging data analytics. Collaborate with cross-functional teams to develop strategic recommendations, track program outcomes, and present findings clearl...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $215K *

Unlock potential by leading the development of a virtual engagement team to enhance outreach to healthcare professionals, ensuring effective collaboration with field sales and marketing for optimal im...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Elevate healthcare solutions by transforming complex data needs into scalable systems. Collaborate with cross-functional teams to design and build data pipelines and insightful dashboards that enhance...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$135K - $155K *

Explore a pivotal role in shaping client relationships and driving agency success. Lead complex projects, mentor teams, and leverage your marketing expertise to deliver impactful solutions in a dynami...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $115K *

Join a dynamic team as a Senior Project Planner, driving financial health and vendor coordination across multiple brands while ensuring project success through strategic planning and effective communi...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K *

Empower the national brand by leading social media strategy, driving engagement, and fostering partnerships. Oversee content creation and analytics to enhance audience reach and conversion across dive...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Media

$123K - $160K *

Champion innovative cancer therapies by leading quality operations for apheresis and treatment centers. Collaborate cross-functionally to ensure compliance and support Kite's rapid expansion in CAR-T...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform the accounting function by overseeing monthly closes, ensuring compliance, and managing tax processes. Collaborate with finance leadership to drive accurate reporting and support strategic p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$78K - $168K *

Drive health outcomes by conducting in-home evaluations, building trust with patients, and providing personalized care. Travel extensively to meet diverse needs, ensuring comprehensive health assessme...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$75K - $105K *

Empower healthcare delivery by ensuring coding accuracy as you analyze medical records, identify improvement opportunities, and enhance AI diagnostic models to uphold high-quality standards in inpatie...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$246K - $332K *

Drive pediatric development strategy by integrating clinical insights and regulatory commitments across multiple therapeutic areas, ensuring effective execution from candidate transition to post-marke...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.