Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$72K - $104K *
Elevate nursing standards by supervising clinical staff, ensuring compliance with policies, and delivering quality patient care in a correctional environment. Collaborate with healthcare teams to enha...
Today
Certified Public Accountant (CPA) - Medicaid/Medicare
$100K - $120K *
Elevate your career by preparing and analyzing complex Medicaid cost reports, ensuring compliance with regulations, and leading a team of accountants in a remote setting. Drive process improvements an...
2 weeks ago
Associate Director, Clinical Supply Chain (Remote)
$150K - $185K *
Architect comprehensive clinical supply strategies for global trials. Collaborate across functional teams to secure timely, compliant drug supply while managing risks and inventory effectively, ensuri...
Reposted 3 days ago
$110K - $130K *
Reimagine medical communication by leading a team of writers to craft regulatory and scientific documents. Oversee projects, ensuring clarity and quality for diverse audiences while adhering to timeli...
Reposted 3 weeks ago
Senior Oncology Account Specialist Prostate Cancer Santa Monica, CA
$108K - $250K *
Join a team that's dedicated to enhancing patient care by promoting innovative oncology solutions. You'll engage with healthcare professionals, drive product awareness, and leverage insights to streng...
Reposted 1 week ago
Senior Oncology Account Manager, Manhattan
$150K - $230K *
Join a team that's dedicated to advancing oncology care by promoting innovative treatments, building strong relationships with healthcare professionals, and driving patient access to essential therapi...
1 week ago
Senior Oncology Account Manager, Louisville
$150K - $230K *
Elevate patient care by driving oncology product success through strategic relationships and innovative solutions. Collaborate with key stakeholders to ensure timely access to therapies while exceedin...
1 week ago
$103K - $128K *
Join us to lead product strategy and development, driving innovation and performance in healthcare solutions. Collaborate cross-functionally to align business needs with customer expectations and ensu...
3 weeks ago
$45K - $250K *
Transform your career by connecting healthcare professionals with meaningful roles. Join a supportive team focused on building relationships and driving results while enjoying unlimited earning potent...
1 week ago
Territory Sales Manager - CCST (Colorado Springs, CO)
$108K - $135K *
Engage in driving sales success within primary care and specialty biopharmaceuticals. Collaborate effectively to execute strategic business plans, achieve sales goals, and launch new products in a dyn...
1 week ago
Account Specialist (Palo Alto / San Francisco, CA)
$160K - $192K *
Lead the charge in driving commercial performance by engaging healthcare providers, building relationships, and executing territory business plans to ensure patient access to innovative therapies and...
1 week ago
Sr. Manager, Finance & Value Realization
$132K - $166K *
Unlock financial insights at a strategic level, driving value realization and governance for transformation investments. Collaborate across functions to enhance performance, support decision-making, a...
2 weeks ago
$100K - $120K *
Join a team that's dedicated to enhancing healthcare technology by developing and maintaining our Electronic Health Record platform using Ruby. Collaborate in an agile environment to deliver impactful...
1 week ago
$200K - $232K *
Unlock potential by leading legal reviews for promotional and medical materials. Collaborate across teams to ensure compliance and provide practical guidance in a fast-paced environment, supporting pr...
2 weeks ago
$121K - $155K *
Empower individuals by providing evidence-based mental health support to patients aged 13+. Collaborate with a dedicated clinical team in a fully remote environment, enhancing patient care and profess...
1 week ago
Senior Oncology Account Manager, Birmingham
$150K - $230K *
Drive impactful oncology solutions by building relationships with key stakeholders. Collaborate with internal teams to enhance patient access and exceed performance goals while managing territory reso...
1 week ago
Patient Programming / Ambassador Manager
$205K - $228K *
Champion patient-focused initiatives by leading strategy and execution of ambassador programs. Build relationships with patients and advocacy groups to enhance engagement and ensure their voices shape...
1 week ago
Senior Specialist Medical Affairs
$113K - $226K *
Optimize customer relationships and educational programs in Cardiac Rhythm Management and Electrophysiology. Collaborate with teams to enhance product adoption and training initiatives, ensuring high...
4 weeks ago
$160K - $190K *
Pioneer innovative AI solutions to transform biomedical discovery, collaborating with top scientists and engineers to bridge virtual and real-world data, enhancing drug discovery and clinical care pro...
Today
Senior Manager, Benefits and Compensation - Remote
$140K - $155K *
Develop and lead comprehensive benefits and compensation programs, ensuring alignment with business goals and enhancing employee experience through strategic management and continuous improvement init...
2 weeks ago
Director, Medical - Clinical Research Scientist
$177K - $338K *
Help us advance women's health through innovative clinical trial strategies, where you will conduct, support, and report on global studies for cutting-edge compounds, ensuring adherence to regulatory...
Reposted 1 week ago
Manager, Applications, Epic Orders
$165K - $264K *
Pioneer cross-functional collaboration to manage IS projects, ensuring successful implementation and support of applications, upgrades, and integrations while overseeing budgets and resources across S...
2 days ago
Territory Sales Manager - Specialty (Boston N, MA)
$125K - $157K *
Advance market share and sales objectives by building strong relationships and leveraging clinical expertise. Collaborate with teams to analyze trends and drive strategic initiatives in a dynamic heal...
2 weeks ago
Sr. Manager, Provider Data Operations & Attribution Integrity
$67K - $199K *
Empower operational excellence by leading provider data governance and attribution processes. Collaborate across departments to ensure data integrity, enhance reporting accuracy, and drive continuous...
1 week ago
Account Specialist, Gainesville-Daytona Beach, FL
$160K - $192K *
Accelerate commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to optimize patient access and support innovative therapies in a dy...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.