Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Physician - Diagnostic Tele-Radiologist
$210K - $250K *
Grow your career by providing comprehensive diagnostic radiology services, including consultations and interpretations for a diverse patient population. Collaborate remotely to ensure timely and accur...
1 week ago
Associate Vice President, Clinical Services - Market Access Marketing
$180K - $220K *
Lead the charge in developing clinical content strategies and overseeing teams within the market access practice. Drive innovation, enhance client strategies, and ensure high standards in service deli...
Reposted 3 weeks ago
Director, Drug Safety Physician
$280K - $311K *
Optimize safety evaluations within our Drug Safety team to drive innovative strategies for monitoring and managing clinical risks, ensuring compliance and maintaining high-quality standards in pharmac...
4 weeks ago
Senior Director, Commercial Analytics & Decision Science
$219K - $285K *
Shape and lead a centralized commercial analytics function, transforming complex data into actionable insights. Drive performance measurement, growth identification, and strategic decision-making acro...
1 week ago
Staff Accountant, USG Contracts
$80K - $93K *
Grow your career with a dynamic Finance team as a Staff Accountant, supporting financial operations for R&D programs and USG contracts. Collaborate across departments to ensure accurate financial reco...
Reposted 6 days ago
Senior Machine Learning Engineer
$156K - $211K *
Unlock your potential as a Senior Machine Learning Engineer, driving innovative AI solutions. Collaborate with cross-functional teams to develop scalable prototypes, translating complex business needs...
4 weeks ago
Assistant General Counsel, Americas
$160K - $200K *
Champion the legal landscape for Phase 3 and commercial activities in the Americas, providing strategic counsel across the product lifecycle while partnering closely with commercial and medical affair...
2 weeks ago
$201K - $251K *
Lead strategic forecasting initiatives to drive decision-making in oncology. Collaborate with cross-functional teams to develop long-term models and communicate insights that shape product and portfol...
2 weeks ago
Account Specialist (Burlington, VT)
$160K - $192K *
Collaborate with healthcare providers to drive commercial performance and product adoption. Engage in territory business planning, support product launches, and optimize patient access to innovative t...
1 week ago
$80K - $85K *
Elevate your career by managing the 340B Drug Pricing Program, ensuring compliance and operational excellence for diverse healthcare clients. Collaborate cross-functionally while driving program integ...
4 weeks ago
Behavioral Health Virtual Preceptor - Nurse Practitioner or Physician Assistant
$100K - $120K *
Unlock potential by mentoring new providers through virtual education, ensuring a seamless onboarding experience. Leverage your clinical expertise to foster growth in both primary care and behavioral...
2 weeks ago
$150K - $180K *
Join a dynamic team to lead and scale clinical operations, overseeing performance and process optimization. Build accountable teams, manage metrics, and partner with stakeholders to enhance operationa...
Reposted 4 weeks ago
Director, Global Drug Safety & Pharmacovigilance Operations
$150K - $180K *
Advance global drug safety initiatives by leading pharmacovigilance activities, ensuring compliance with regulations, and collaborating with cross-functional teams to enhance product safety and operat...
2 days ago
Medical Science Liaison, West (Multiple Territories)
$155K - $175K *
Champion the field as a Medical Science Liaison, driving prelaunch strategies and fostering relationships with key stakeholders. Leverage clinical insights to educate and influence healthcare professi...
2 weeks ago
Physician (Diagnostic Radiologist)
$210K - $250K *
Empower patient care through expert image interpretation and guidance in diagnostic radiology. Collaborate on quality assurance, oversee technical standards, and educate staff while ensuring optimal p...
3 days ago
Senior Service Desk Technician
$120K - $150K *
Unlock a seamless end-user experience by overseeing technical support, mentoring, and cross-functional collaboration in a dynamic IT environment dedicated to operational excellence and service improve...
Reposted 1 week ago
$80K - $95K *
Drive revenue cycle operations by managing processes from entry to adjudication. Lead teams, implement efficiencies, and ensure compliance while optimizing cash collections and performance metrics for...
Reposted 3 days ago
$80K - $100K *
Drive innovative palliative care solutions for members with complex needs, providing compassionate, evidence-based support through telehealth. Collaborate with interdisciplinary teams to enhance patie...
3 weeks ago
$156K - $214K *
Inspire growth by leading an Enterprise CPG sales team, driving strategic partnerships with top-tier brands, and influencing C-suite executives to leverage innovative insights for impactful decisions...
Today
$168K - $231K *
Join a dynamic team to lead Nurse Case Managers, enhancing patient support and education throughout treatment journeys while ensuring compliance and quality in case management processes...
1 week ago
$152K - $202K *
Drive patient access by leveraging your expertise in reimbursement and market access. Collaborate with healthcare providers to navigate complex payer landscapes, ensuring timely access to therapies wh...
3 weeks ago
$150K - $200K *
Elevate your career by leading HCP engagement and clinical marketing initiatives. Drive strategic insights and educational content for the HSCT portfolio, fostering impactful connections and enhancing...
Yesterday
Account Manager, Dietary Supplements (California, Arizona, New Mexico)
$120K - $145K *
Champion sales growth in the dietary supplements sector by managing client relationships, analyzing market trends, and driving innovative solutions to meet profitability targets and enhance brand posi...
6 days ago
Executive Director, Health Economics & Outcomes Research (HEOR)
$246K - $332K *
Shape the future of health economics and outcomes research by leading strategic initiatives across the nephrology portfolio, ensuring high-quality evidence generation and collaboration with cross-func...
1 week ago
Transportation Consultant - Final Mile
$68K - $97K *
Lead operational stability and process standardization for transportation across multiple facilities. Collaborate with planners and logistics partners to enhance delivery performance and resolve disru...
Today
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.