Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,442

Sort By: Relevance

$95K - $115K *

Drive innovation by designing and developing advanced electrical systems for industrial semiconductor equipment, ensuring seamless integration and collaboration across teams and vendors to meet evolvi...

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Analyze labor market data and audience behaviors to develop actionable insights that enhance recruitment marketing strategies. Collaborate with cross-functional teams to create data-driven audience pe...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$105K - $141K *

Contribute to the development of data and tooling capabilities that drive GTM growth strategies. Collaborate across teams to translate business needs into scalable solutions, enhancing marketing and r...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$80K - $95K *

Lead the charge in managing site operations and vendor relations, ensuring compliance and efficiency in clinical research projects. Collaborate with teams to streamline processes and enhance training...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$122K - $204K *

Shape the future of operations by providing strategic leadership, driving measurable improvements, and fostering cross-functional collaboration to enhance performance, service quality, and customer ou...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$230K - $275K *

Join a team that's redefining B2B sales by leading and mentoring a high-performing regional team while driving significant revenue growth and building a vibrant sales culture in a rapidly scaling envi...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Advance public health initiatives by conducting epidemiologic studies, analyzing data, and providing consultation to partners. Translate findings into actionable insights to improve community health o...

Today

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Transform public health through innovative epidemiologic studies and data analysis. Collaborate with federal, state, and local partners to assess health trends and provide actionable insights that enh...

Today

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Analyze public health data and conduct epidemiologic studies to identify trends and inform interventions. Collaborate with partners to enhance surveillance systems and translate findings into actionab...

Today

  •   Less than 5 years exp.  •   Healthcare

$146K - $269K *

Shape the future of enterprise software by leading multiple engineering teams, driving application development, and implementing best practices. Collaborate cross-functionally to enhance quality and s...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$180K - $220K *

Join a team that's dedicated to providing comprehensive, patient-centered primary care in an outpatient setting. Collaborate with a supportive team to enhance health outcomes for individuals and famil...

Today

  •   Less than 5 years exp.  •   Healthcare

$75K - $95K *

Accelerate client onboarding by leading the implementation lifecycle, ensuring seamless coordination across departments. Drive alignment and maintain operational infrastructure for successful account...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $180K *

Drive your career with a leadership role overseeing enterprise sales, guiding a team to exceed quotas while developing strategies that align with market opportunities and fostering strong client relat...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$118K - $180K *

Engineer innovative SCADA systems for diverse client projects, focusing on automation and communication solutions. Collaborate with teams to design, troubleshoot, and enhance electric grid infrastruct...

Today

  •   8 - 10 years exp.  •   Technical Services

$173K - $272K *

Drive innovation in vaccine commercialization by leading a skilled team of scientists and engineers. Oversee technical development, regulatory compliance, and strategic alignment to ensure successful...

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$94K - $138K *

Engage in aircraft maintenance, ensuring operational readiness and safety in OCONUS environments. Collaborate closely with teams, manage logistics, and maintain accurate aircraft records while adaptin...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Aerospace & Defense

$142K - $224K *

Transform operational strategy and execution for a high-impact organization, leading governance, cross-functional alignment, and talent development to ensure timely, compliant delivery of key initiati...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$118K - $180K *

Drive innovative SCADA system designs for electric grid solutions, engaging in client projects to enhance automation and communication systems. Collaborate with engineers and clients to ensure timely...

Today

  •   8 - 10 years exp.  •   Technical Services

$88K - $107K *

Unlock potential by supporting core accounting operations through journal entries, reconciliations, and financial close activities. Collaborate with teams to ensure compliance and accuracy while devel...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $160K *

Champion the transformation of web initiatives into impactful projects, overseeing the entire lifecycle from planning to launch. Collaborate with cross-functional teams to enhance user experience and...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Accelerate progress at driving new business growth in IP services by engaging corporate IP departments and legal teams. Leverage consultative selling to expand accounts and build lasting relationships...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Legal & Accounting

$80K - $95K *

Lead the charge in developing a comprehensive training ecosystem for Employer Service specialists, ensuring they are equipped with the knowledge and skills to deliver exceptional service to 401(k) pla...

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $110K *

Elevate your career by driving innovative structural designs for light-gauge and cold-formed steel systems in modular and prefabricated buildings, ensuring compliance with California codes and enhanci...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Oversee complex Installation Services projects, ensuring timely delivery and alignment with client needs. Collaborate with cross-functional teams to manage budgets, foster client relationships, and me...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Information Technology

$72K - $120K *

Unlock your potential by leading creative strategy and visual design initiatives. Drive brand evolution and campaign execution while mentoring teams to enhance the College Board's visual identity acro...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.