Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,459

Sort By: Relevance

$73K - $88K *

Drive financial stewardship and risk management by supporting the Finance Manager in enhancing financial systems and processes, ensuring compliance, and delivering effective solutions for humanitarian...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Join a team that's dedicated to delivering compassionate orthopedic care across clinic, surgical, and inpatient settings. Engage with patients throughout their recovery journey while collaborating in...

Reposted today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$165K - $175K *

Lead global clinical trials, managing cross-functional teams to ensure project success across multiple therapeutic areas while driving operational excellence and best practices in clinical project man...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Staffing

$115K - $127K *

Join a team that's dedicated to advancing oncology research by monitoring clinical trials, ensuring compliance, and supporting investigative sites throughout the trial lifecycle. Your expertise will d...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Staffing

$70K - $110K *

Champion the implementation and support of Windows Server environments, ensuring optimal performance and security across diverse customer infrastructures while collaborating with technical teams and s...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Technical Services

$130K *

Elevate your career by providing clinical education and support, collaborating with healthcare professionals to enhance device adoption and usage, while ensuring effective communication and training i...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$127K - $159K *

Drive statistical leadership in oncology clinical development, guiding study design, analysis, and regulatory submissions. Collaborate with cross-functional teams to ensure high-quality deliverables a...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Drive innovative strategies in generative engine optimization, leading client accounts and teams to enhance visibility and authority in AI-driven search landscapes while ensuring measurable outcomes a...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Lead strategic business development efforts in the Northeast, driving growth across Agribusiness and Industrial Water sectors while managing client relationships and achieving sales goals. Influence o...

Reposted today

  •   11 - 15 years exp.  •   Real Estate & Construction

$120K - $145K *

Join a dynamic team to lead and execute innovative power generation projects, focusing on natural gas and renewable energy. Mentor engineers, manage client relationships, and drive design excellence i...

Today

  •   8 - 10 years exp.  •   Real Estate & Construction

$83K - $93K *

Join a team that's dedicated to delivering exceptional nursing care in a 5-Star-rated facility. As a Weekend RN Supervisor, you'll oversee nursing staff, ensure quality care, and maintain a safe envir...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Champion editorial excellence by driving content development and strategy for health services journals. Collaborate with diverse teams and stakeholders to ensure high-quality, impactful publications w...

Today

  •   5 - 7 years exp.  •   Media

$80K - $93K *

Grow your career with a dynamic Finance team as a Staff Accountant, supporting financial operations for R&D programs and USG contracts. Collaborate across departments to ensure accurate financial reco...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$118K - $196K *

Unlock your potential in a dynamic role focused on drug formulary development, compliance, and utilization management. Collaborate with cross-functional teams to enhance pharmacy strategies and improv...

Pennsylvania, USRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in transforming water treatment solutions by overseeing design, project delivery, and team development. Drive profitability and operational excellence while managing complex projects f...

Today

  •   8 - 10 years exp.  •   Energy & Utilities

$120K - $145K *

Advance healthcare solutions by developing scalable ML systems, collaborating with cross-functional teams, and driving innovative AI methodologies to enhance patient outcomes and optimize operational...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Unlock potential by driving pricing excellence and delivering actionable insights. Collaborate cross-functionally to enhance pricing strategies, optimize performance, and support revenue growth in a d...

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$72K - $90K *

Shape the future of business travel by managing bid responses and collaborating with teams to ensure high-quality proposals that meet client needs and company standards. Engage with subject matter exp...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Transportation

$80K - $95K *

Shape tax strategies and compliance processes by leveraging your expertise to manage complex reporting, audits, and analysis. Collaborate with finance teams to enhance operations and drive professiona...

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Lead the charge in ensuring nuclear safe shutdown post-fire through strategic oversight, regulatory compliance, and project execution while guiding a diverse engineering team to enhance fire protectio...

Reposted today

  •   8 - 10 years exp.  •   Real Estate & Construction

$95K - $115K *

Elevate project delivery by leading Agile teams, ensuring effective scrum processes, and fostering collaboration across functions to achieve high-quality outcomes and timely releases...

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$82K - $150K *

Drive growth by aggressively prospecting and converting new dental accounts while expanding existing relationships. Utilize a hunter mentality to identify opportunities and position value-oriented imp...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Lead the Project Procurement and Logistics functions for complex projects, ensuring strategic sourcing, supplier management, and transportation strategies align with project goals, timelines, and budg...

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$130K - $190K *

Partner with us to lead global portfolio strategy and execution for engineered products. Drive cross-functional collaboration, manage product roadmaps, and influence commercial outcomes to achieve mea...

Reposted today

  •   11 - 15 years exp.  •   Real Estate & Construction

$110K - $130K *

Join a team that's driving innovation by leading cross-functional programs that enhance business engagement and operational efficiency, bridging technology and strategy to support growth in a dynamic...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.