Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,442

Sort By: Relevance

$160K - $200K *

Lead the charge in advancing immunotherapeutics and protein engineering through innovative research, collaboration, and faculty engagement, while managing the newly established Center for Immunotherap...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$88K - $150K *

Lead contract management initiatives by drafting, negotiating, and overseeing agreements while collaborating with cross-functional teams to enhance efficiency and support strategic legal operations in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$88K - $105K *

Explore a leadership role in municipal engineering, managing impactful projects from planning to implementation while fostering client relationships and expanding services across communities in Wester...

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$110K - $130K *

Lead scientific initiatives across medical affairs, ensuring accuracy and strategic alignment. Mentor junior writers while managing client relationships and contributing to business growth through ins...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$137K - $200K *

Join a team that's passionate about safeguarding sensitive data through innovative product marketing strategies for Data Loss Prevention. Leverage your expertise to drive market awareness and enable s...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$108K - $130K *

Grow your career with a dynamic team as you lead Oracle Fusion Financials integrations, collaborating across departments to design and implement scalable financial solutions in a regulated environment...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$157K - $185K *

Shape the future of AI security by driving sales of innovative solutions. Own the full sales cycle, engage with enterprise clients, and collaborate with teams to expand our market presence while navig...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$105K - $130K *

Join a team that's dedicated to transforming the future of healthcare finance. Collaborate with cross-functional teams to enhance service delivery and drive innovative solutions that empower clients a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $185K *

Transform client relationships by leading a dynamic team focused on customer success. Drive engagement, satisfaction, and operational excellence while shaping a new line of business in a services-led...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $110K *

Drive innovative data solutions by managing ETL processes and preparing AI datasets. Collaborate in a fast-paced Agile environment to translate complex requirements into efficient data strategies, ens...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Drive impactful data analysis and risk management for global clinical trials, interpreting complex data to identify trends and risks. Lead cross-functional teams in enhancing study quality and patient...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$140K - $195K *

Lead incident response efforts by managing partner investigations, ensuring alignment with customer objectives, and enhancing security practices. Collaborate with teams to deliver high-quality results...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Drive successful customer engagements by managing SaaS solution delivery, building strong client relationships, and enhancing project execution within a dynamic, fast-paced environment...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$162K - $186K *

Build and enhance backend services for a global insurance platform, collaborating with cross-functional teams to deliver scalable solutions and improve user experience through data-driven insights and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$150K - $180K *

Drive growth by crafting tailored marketing strategies for diverse client segments. Lead a team to optimize audience insights and campaign performance, ensuring alignment with commercial goals and max...

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$160K - $210K *

Join a team that's driving innovation in cloud security and IoT systems. Collaborate with Fortune 500 clients, providing technical expertise and solutions while traveling extensively to enhance custom...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$98K - $163K *

Explore innovative data solutions to enhance decision-making and operational efficiency for healthcare clients. Collaborate on analytics, machine learning, and application development to drive impactf...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$125K - $150K *

Join a dynamic team as a subject-matter expert, providing strategic guidance and bespoke insurance solutions for complex multi-generational family offices, while influencing product development and en...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $159K *

Pioneer the management of clinical research projects, ensuring timely execution and compliance. Collaborate with cross-functional teams to achieve project goals while maintaining strong relationships...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Champion facility operations by leading maintenance programs and managing diverse teams. Drive strategic initiatives to enhance building performance and ensure compliance with regulations while optimi...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Lead the charge in driving enterprise sales by managing the full account lifecycle, from prospecting to renewals. Collaborate with C-level executives to enhance customer experiences and achieve strate...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$294K - $346K *

Unlock potential by driving strategic partnerships with PSPs, fintechs, and banks. Manage the full deal lifecycle while collaborating cross-functionally to enhance Coinbase's stablecoin payment soluti...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$99K - $136K *

Manage the delivery of timely CDL Medical Examinations, ensuring compliance with FMCSA regulations while coordinating with various teams to support employee health and safety. Play a key role in case...

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$113K - $142K *

Engineer innovative electrical designs for modular data centers, ensuring compliance and performance across international standards. Collaborate with teams to deliver hands-on solutions from concept t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Elevate enterprise architecture by serving as a senior technical authority, guiding the development of architectural visions and frameworks, and advising on technology adoption and modernization initi...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.