Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $122,395

Sort By: Relevance

$179K - $204K *

Drive innovation by leading diverse tech projects and teams, leveraging cutting-edge technologies to create impactful solutions that empower millions. Collaborate in a fast-paced environment to enhanc...

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$179K - $204K *

Lead the charge in developing innovative machine learning solutions that drive AI transformations. Collaborate with cross-functional teams to design, build, and deploy scalable models, ensuring best p...

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Join a team that's dedicated to ensuring compliance and quality in site contracts. Manage negotiations, oversee contract processes, and collaborate with clients and experts to deliver timely and effec...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K *

Champion the clinical operations team, ensuring project success through resource management, process efficiencies, and compliance. Drive training, metrics development, and mentorship to enhance team c...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Lead a high-performing branch team to drive customer growth and satisfaction through effective coaching, operational excellence, and risk management. Foster a culture of accountability while deliverin...

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $190K *

Unlock potential by serving as a functional SME in Workday solutions, advising and configuring systems to meet client needs. Balance multiple projects while ensuring timely issue resolution and delive...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $110K *

Join our new Data Engineering team to lead business intelligence initiatives, build trusted data models in Snowflake, and deliver impactful reports in Power BI. Collaborate with stakeholders to enhanc...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Champion endpoint strategy and governance, leading a specialized team to deliver secure, scalable services across diverse devices. Collaborate with IT and business leaders to drive automation, operati...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $190K *

Lead the evolution of a Project Management Centre of Excellence, establishing standards and governance to enhance clinical project delivery. Drive capability building and influence stakeholders across...

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Advance patient recruitment and retention by developing site-specific strategies, educating healthcare professionals, and analyzing performance data to enhance clinical trial outcomes and participant...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $138K *

Champion clinical trial excellence by overseeing monitoring activities, ensuring compliance with protocols and regulations, and fostering collaboration across teams to drive successful trial execution...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $115K *

Innovate in cybersecurity as you drive technical conversations and deliver tailored solutions. Collaborate with sales teams to enhance customer relationships and showcase the unique value of next-gen...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $128K *

Unlock potential by driving cloud security sales initiatives, collaborating with teams, establishing partnerships with key personas, and engaging customers to integrate innovative security solutions i...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $195K *

Transform project delivery by leading a team of Project Managers to ensure timely, budget-conscious deployment of customer projects while enhancing processes and driving efficiency across cross-functi...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Engineer actionable investment insights by analyzing complex data, collaborating across teams, and translating findings into compelling narratives for diverse investor audiences. Drive impactful resea...

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$77K - $118K *

Transform network operations by designing and implementing automation solutions that enhance reliability and efficiency across multi-vendor infrastructures, utilizing advanced technologies like Python...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Information Technology

$77K - $118K *

Drive the evolution of scalable, secure platforms by architecting solutions that enhance network intelligence and application delivery, collaborating with cross-functional teams to optimize performanc...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $220K *

Lead the evolution of a global product portfolio, driving growth and integration of AI-native research intelligence solutions while managing a diverse team and aligning with key stakeholders...

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$174K - $234K *

Champion the development and governance of global transfer pricing strategies, ensuring alignment with business operations and compliance across jurisdictions while leading cross-functional collaborat...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$204K - $274K *

Champion the U.S. Biologics Regulatory CMC team by providing strategic leadership, ensuring timely regulatory submissions, and fostering collaboration among global stakeholders to drive innovative bio...

United StatesRemote

Reposted 6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$167K - $300K *

Unlock your potential by leading regional oncology thought leader engagement and advocacy strategies. Collaborate with cross-functional teams to shape brand strategy and launch planning for innovative...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$167K - $300K *

Elevate oncology marketing strategies by leading KOL engagement and advocacy initiatives. Utilize market insights to shape brand strategy and launch planning for innovative therapies, ensuring complia...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$167K - $300K *

Lead the charge in transforming cancer treatment through strategic KOL engagement and advocacy. Drive regional initiatives, leveraging market insights to shape brand strategy and launch planning for i...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$167K - $300K *

Lead the charge in oncology marketing by developing KOL engagement strategies and insights for individualized therapies. Collaborate cross-functionally to drive brand strategy and launch planning, ens...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$79K - $112K *

Transform cash forecasting processes by leveraging technology and analytics. Collaborate with Treasury leadership to enhance cash flow insights and automate reporting, ensuring accuracy and efficiency...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.