Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,442

Sort By: Relevance

$110K - $130K *

Join a team that's dedicated to optimizing database performance and security. You'll manage routine operations, troubleshoot issues, and implement design changes, ensuring reliable database functional...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$180K - $190K *

Drive impactful growth of our subscription program by shaping market strategies, enhancing member engagement, and leveraging user insights to position offerings that attract and retain loyal customers...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Consumer Technology

$88K - $105K *

Shape the future of healthcare revenue management by leading IDR processes, ensuring compliance, and driving data-informed improvements while mentoring a team of analysts to optimize workflows and enh...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$207K - $218K *

Champion innovative machine learning solutions to enhance service availability, optimize routing, and improve fulfillment efficiency in a complex logistics environment, driving profitability and shopp...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Consumer Technology

$299K - $343K *

Advance your career with a leading academic medical center offering a flexible outpatient-focused schedule, teaching opportunities, and a supportive environment for clinical growth and research partic...

Today

  •   Less than 5 years exp.  •   Healthcare

$180K - $240K *

The Technical Strategy & Execution Lead will oversee the execution of client, research, and product initiatives, transforming abstract ideas into actionable roadmaps. This role requires leading high-s...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$90K - $100K *

Join a team that's dedicated to driving impactful pharmaceutical brand strategies. As a key client interface, you'll manage relationships, oversee project execution, and ensure compliance across high...

Today

  •   5 - 7 years exp.  •   Staffing

$90K - $100K *

Champion client relationships and drive strategic initiatives in the pharmaceutical sector. Leverage expertise in brand strategy and compliance to manage high-impact projects, ensuring seamless collab...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Staffing

$70K - $196K *

Lead the development of innovative robotics solutions, managing interdisciplinary teams to enhance industrial applications through scalable AI architectures and real-time systems, while collaborating...

Today

  •   Less than 5 years exp.  •   Business Services

$70K - $196K *

Join a team that's pioneering scalable robotics solutions, driving innovation in AI and automation. Collaborate with experts to tackle industry challenges and enhance efficiency, safety, and cost-effe...

Today

  •   Less than 5 years exp.  •   Business Services

$87K - $104K *

Champion the development of AI-native software across the stack, from front end to cloud infrastructure. Collaborate with teams to deliver production-ready features, leveraging AI tools and best pract...

Today

  •   Less than 5 years exp.  •   Business Services

$65K - $98K *

Advance operational excellence by supervising teams, managing productivity, and ensuring compliance with quality and safety standards. Drive performance through effective communication and training, f...

Today

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$87K - $104K *

Pioneer innovative software solutions across the stack, integrating AI tools and cloud technologies. Collaborate with teams to deliver impactful features, ensuring quality and performance in productio...

Today

  •   Less than 5 years exp.  •   Business Services

$132K - $302K *

Elevate global sales strategies by orchestrating cross-functional teams, driving pursuit excellence, and leveraging domain expertise to secure competitive deals in the GCC landscape. Collaborate with...

Reposted today

  •   11 - 15 years exp.  •   Business Services

$132K - $302K *

Shape the future of GCC sales strategies by leading complex pursuits across the Americas. Leverage your domain expertise and cross-deal intelligence to drive effective collaboration and enhance propos...

Reposted today

  •   11 - 15 years exp.  •   Business Services

$95K - $115K *

Transform project delivery by leading capital and operating projects at JFK. Manage all phases from initiation to close-out, ensuring alignment with client goals and stakeholder interests while naviga...

Today

  •   5 - 7 years exp.  •   Business Services

$193K - $309K *

Lead the development of innovative drive-thru solutions, architecting scalable Android applications and backend integrations while mentoring engineers and driving engineering excellence across the org...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $193K *

Accelerate progress at the intersection of security and technology by leading integration product management for enterprise security capabilities across multiple business units, ensuring streamlined a...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$73K - $102K *

Shape the future of technology by leading automation efforts, enhancing software quality, and collaborating across teams to deliver innovative solutions. Drive the development and implementation of ro...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$128K - $205K *

Join us to transform the retail landscape by building relationships with convenience stores and grocery outlets. Utilize your sales expertise to drive our innovative solutions, ensuring success for ne...

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $200K *

Lead the charge in optimizing clinical documentation processes, enhancing provider education, and fostering collaboration with service line leaders to improve documentation integrity and reduce admini...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$157K - $196K *

Drive safety evaluation and risk management for assigned programs, collaborating with cross-functional teams to ensure compliance and effective governance in pharmacovigilance activities, while suppor...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$86K - $124K *

Lead the charge in transforming lives as a Board-Certified Behavior Analyst, providing tailored ABA services to children and adolescents. Collaborate with a multidisciplinary team to foster growth and...

Today

  •   Less than 5 years exp.  •   Healthcare

$125K - $165K *

Empower public housing clients by leading Yardi software implementations, optimizing workflows, and enhancing operational efficiency. Collaborate with stakeholders to resolve issues and drive value in...

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$125K - $165K *

Deliver exceptional Yardi software solutions for public housing clients, optimizing implementations and configurations. Collaborate with stakeholders to enhance workflows, troubleshoot issues, and ens...

Today

  •   5 - 7 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.