Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,477

Sort By: Relevance

$88K - $105K *

Optimize production processes by leading PET personnel, ensuring compliance with safety and quality standards, and fostering a collaborative work environment. Drive continuous improvement and support...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Lead the charge in providing exceptional in-patient neurology care while actively teaching medical students and residents at a community hospital dedicated to improving brain health and patient outcom...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$77K - $202K *

Empower clients by analyzing and enhancing commodities trading systems. As a Senior Associate, you'll lead projects, mentor teams, and drive operational efficiency through strategic sourcing and procu...

Today

  •   Less than 5 years exp.  •   Legal & Accounting

$77K - $202K *

Shape operational excellence by enhancing commodities trading systems, analyzing procurement processes, and mentoring teams to drive efficiency and supplier collaboration in a dynamic consulting envir...

Today

  •   Less than 5 years exp.  •   Legal & Accounting

$99K - $232K *

Deliver impactful test execution leadership for bank platform transformations, guiding teams in planning, quality assurance, and stakeholder engagement to ensure successful outcomes in core banking op...

Today

  •   Less than 5 years exp.  •   Legal & Accounting

$113K - $254K *

Drive innovation by developing scalable Python services and AI-driven solutions. Collaborate with data science teams to enhance pricing automation and improve operational efficiency in a fully remote...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Transportation

$132K - $170K *

Transform client relationships and drive growth by consulting with C-level executives to implement strategic solutions that enhance value and satisfaction across major accounts, ensuring retention and...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Business Services

$172K - $202K *

Lead the charge in delivering innovative insights and strategies for clients, leveraging in-depth market analysis and research expertise to address complex challenges and drive actionable results for...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Business Services

$120K - $145K *

Accelerate commercial growth by defining strategies for product families, collaborating across teams to translate market insights into actionable plans that drive revenue, profitability, and customer...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Healthcare

$180K - $220K *

Lead the sales strategy for a healthcare Payer business unit, driving market penetration, revenue growth, and client satisfaction. Collaborate with leadership to shape go-to-market strategies and buil...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Healthcare

$65K - $155K *

Engage customers by guiding them through vehicle repair processes, ensuring quality standards and exceptional service. Manage estimates and repairs while keeping clients informed, fostering a positive...

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Drive strategic growth by leading major enterprise-level pursuits, fostering collaboration across teams, and ensuring operational excellence throughout the sales lifecycle. Leverage insights to refine...

Today

  •   11 - 15 years exp.  •   Real Estate & Construction

$187K - $220K *

Transform product marketing by shaping positioning, launching AI features, and driving go-to-market strategies. Collaborate with cross-functional teams to influence product direction and execute impac...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$75K - $100K *

Drive operational excellence by managing maintenance and field service projects, ensuring timely delivery and compliance with safety standards while collaborating with cross-functional teams to enhanc...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$110K - $145K *

Shape the future of energy efficiency by leading complex client programs and strategic initiatives. Drive portfolio success through operational excellence, financial performance, and strong client rel...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Energy & Utilities

$80K - $95K *

Drive excellence in patient care as an ECMO Specialist, operating and maintaining ECMO circuits while collaborating with clinical teams to ensure optimal support for patients requiring advanced cardio...

Today

  •   Less than 5 years exp.  •   Healthcare

$80K - $120K *

Join a mission-driven team as an Account Executive, where you'll engage with K-12 district leaders, build partnerships, and drive sales to improve outcomes for English learners across a diverse territ...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$145K - $165K *

Drive impactful clinical research strategies by collaborating with cross-functional teams, analyzing data, and disseminating findings through publications and presentations. Elevate your career while...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Empower your career by delivering high-quality healthcare services, collaborating with physicians, and advocating for patients. Engage in diagnostics, treatment planning, and education while participa...

Today

  •   Less than 5 years exp.  •   Healthcare

$151K - $211K *

Innovate strategic technology solutions by advising executive clients, guiding IT transformations, and driving impactful initiatives across diverse technology portfolios. Collaborate with teams to ens...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$130K - $150K *

Drive the pre-execution contract lifecycle for pharmacy and medical benefits, ensuring clear agreements and timely completion. Collaborate with cross-functional teams to enhance contracting processes...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$190K - $250K *

Engage with cloud partners to drive co-sell strategies, enhance pipeline growth, and foster relationships. Act as a liaison between internal sales teams and cloud partners, ensuring alignment and exec...

Today

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Unlock potential by leading the design and implementation of robust data solutions. Drive data infrastructure for analytics and reporting, ensuring compliance and scalability while mentoring junior en...

Today

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in overseeing microbiology lab operations, ensuring compliance with regulatory standards while supporting testing of materials and products. Provide leadership to staff, maintain data...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$128K - $160K *

Lead the charge in implementing software solutions, guiding clients through complex configurations and best practices. Manage multiple large-scale projects while mentoring teams and ensuring client sa...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.