Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $122,395

Sort By: Relevance

$150K - $180K *

Lead the charge in managing a technical team focused on Gitaly, driving performance, scalability, and maintainability while fostering a culture of accountability and ownership across distributed teams...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$88K - $148K *

Join a team that's transforming technology platforms and driving innovation. Leverage your mainframe expertise to deliver critical support and enhancements, ensuring seamless operations and contributi...

5 days ago

  •   Less than 5 years exp.  •   Business Services

$79K - $118K *

Unlock potential by providing compassionate care to terminally ill patients and their families. Collaborate with an interdisciplinary team to ensure quality of life and effective treatment plans while...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $105K *

Join our Intellectual Property team as a Patent Projects Administrator, where you'll coordinate patent software upgrades, support docketing operations, and enhance team training while ensuring complia...

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$148K - $313K *

Unlock potential by serving as a strategic advisor to enterprise clients, guiding them in architecting AI-first solutions within the Life Sciences sector, while driving internal initiatives and enhanc...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's redefining application security by guiding customers through complex evaluations. Leverage your expertise in offensive security to build relationships, deliver impactful demos, and...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Drive growth by building and expanding enterprise pipelines through strategic outbound efforts and executive networking. Collaborate cross-functionally to secure high-value deals and establish long-te...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Shape the future of seasonal influenza operations by leading cross-functional teams to ensure seamless execution across all channels, from demand planning to delivery. Drive strategic initiatives and...

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$64K - $128K *

Join a dynamic team to drive sales and enhance guest experiences through effective management of operations, inventory, and team leadership in a fast-paced retail environment. Develop strategies to en...

5 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$108K - $130K *

Lead the charge in enhancing container security and governance, bridging application teams and platform engineering. Drive solutions for complex issues, ensuring secure, efficient deployment of contai...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Unlock potential by architecting innovative IT solutions that align with client goals. Collaborate with sales teams and engage directly with customers to deliver tailored strategies, ensuring successf...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Unlock potential by leading compensation strategies that attract and retain top talent. Collaborate with executives to shape innovative compensation programs, ensuring alignment with organizational go...

5 days ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$73K - $132K *

Join a dynamic team as a Senior Environmental Chemist, providing expert oversight in environmental data management and validation. Lead projects ensuring compliance and quality in remediation efforts...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Technical Services

$120K - $145K *

Lead the charge in enterprise architecture, guiding teams to optimize application performance and align technology with business goals. Collaborate with stakeholders to develop strategic roadmaps and...

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$144K - $230K *

Engage with our sales team as a Technical Sales Lead, driving technology evaluations and managing customer relationships. Leverage your expertise in telecommunications to ensure satisfaction throughou...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$110K - $159K *

Empower the Clinical Documentation Integrity team by ensuring staff competency through quality assurance, training, and performance management. Collaborate on action plans and foster associate develop...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$225K - $418K *

Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$236K - $439K *

Pioneer transformative initiatives by leading portfolio management, optimizing resource allocation, and driving strategic value realization across diverse business functions. Collaborate with cross-fu...

5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$75K - $89K *

Engage with business lines to provide analytical support, enhance sales processes, and resolve inquiries. Collaborate with teams to implement banking products and ensure effective communication across...

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$152K - $283K *

Accelerate analytics governance and operations by leading initiatives that enhance decision-making processes, streamline reporting, and modernize workflows across teams, ensuring effective collaborati...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$123K - $168K *

Engage with healthcare professionals to drive product growth and acceptance. Build lasting relationships, educate stakeholders, and collaborate cross-functionally to enhance market presence and uphold...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$155K - $258K *

Shape the future of AI in healthcare by leading architectural design and technical strategy for LLM-powered systems. Mentor engineers, ensure compliance, and drive innovation in a highly regulated env...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Shape the future of customer engagement by leading CRM initiatives, driving the design and implementation of Microsoft CE solutions, and mentoring a skilled team to enhance client satisfaction and ope...

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$105K - $120K *

Drive the substantiation of health claims for dietary supplements by reviewing scientific evidence and collaborating with cross-functional teams to ensure compliance with regulatory standards and enha...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Technical Services

$156K - $281K *

Drive innovative solutions by leading complex Federal acquisitions, guiding cross-functional teams, and delivering high-quality proposals. Leverage technical expertise to elevate win probability and e...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.