Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $122,521

Sort By: Relevance

$82K - $98K *

Advance your career in outpatient orthopedic physical therapy, focusing on patient care while enjoying competitive pay, mentorship, and growth opportunities in a supportive team environment...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $238K *

Champion patient access initiatives by leading a field-based team, driving performance metrics, and enhancing communication across healthcare providers to ensure patient needs are met effectively and...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $145K *

Lead the charge in delivering high-quality medical writing for regulatory submissions, collaborating with cross-functional teams to ensure clarity and compliance in clinical documentation while mentor...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $214K *

Drive growth by cultivating relationships with State Government agencies, leveraging your extensive sales experience to deliver innovative software solutions that enhance operational efficiency and ex...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$85K - $94K *

Empower public safety by leading homeland security initiatives, enhancing emergency preparedness, and fostering collaboration among agencies to ensure effective response and recovery in Philadelphia's...

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Join a team that's dedicated to optimizing plant operations and maintenance. Lead engineering initiatives, ensure compliance with safety regulations, and drive performance improvements to achieve oper...

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Advance upstream process development for large molecule products, ensuring compliance with cGMP practices. Collaborate in lab work, data analysis, and technical reporting to support scale-up projects...

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $350K *

Elevate your sales career by engaging with pre-qualified homeowners, assessing their needs, and providing tailored home improvement solutions in a supportive, consultative environment without cold cal...

3 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$129K - $203K *

Lead quality oversight and strategy for clinical supply chains, ensuring compliance and reliability in support of clinical development programs. Collaborate cross-functionally to navigate complex chal...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a team that's driving customer success by optimizing renewal strategies and commercial operations. You'll lead contract negotiations, protect revenue, and enhance operational efficiency while col...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$77K - $101K *

Empower your career as you collaborate on innovative AI solutions, driving product delivery and operational excellence. Engage with cross-functional teams to enhance user experiences and support clien...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Business Services

$95K - $115K *

Shape the future of defense programs by managing technology initiatives, supporting federal acquisitions, and driving business development efforts. Collaborate with diverse teams to translate complex...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$150K - $180K *

Join a team that's leading the construction of cutting-edge AI data centers. Oversee multiple projects from design to energization, ensuring safety, quality, and efficiency while managing diverse team...

3 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$79K - $127K *

Empower your career by managing and optimizing critical DB2 databases, ensuring high availability and performance in a dynamic healthcare environment. Collaborate with teams to drive continuous improv...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$99K - $115K *

Lead the charge in designing and coordinating mechanical systems for diverse projects. Ensure compliance, constructability, and alignment with client goals while managing documentation and client comm...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Technical Services

$96K - $111K *

Drive the administration and analysis of employee benefits programs, ensuring compliance and enhancing the associate experience. Collaborate with HR and external vendors to manage health, retirement...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$92K - $139K *

Join a team that's driving growth by expanding biopharma collaborations. You'll identify opportunities, negotiate agreements, and manage partnerships to enhance market share and revenue, contributing...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$92K - $139K *

Join a team that's driving innovation in biopharma by identifying and pursuing strategic partnerships. You'll collaborate with cross-functional teams to negotiate agreements and manage relationships...

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $125K *

Lead innovative product marketing strategies to empower financial advisors. Collaborate cross-functionally to translate complex solutions into clear value propositions, driving adoption and enhancing...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $190K *

Shape the future of commercial law by leading negotiations and advising on product launches. Collaborate with cross-functional teams to enhance legal processes and support strategic growth initiatives...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $140K *

Lead the charge in driving revenue growth and client retention by managing strategic relationships and optimizing operational strategies for a diverse portfolio of enterprise clients in the transporta...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Transportation

$91K - $148K *

Join a team that's dedicated to enhancing software security and privacy. Leverage your expertise to tackle complex security challenges, collaborate with engineers, and influence product development fo...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$206K - $283K *

Elevate security solutions for public sector clients by showcasing Idira's identity security offerings. Engage with stakeholders, manage technical evaluations, and drive adoption of innovative solutio...

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$69K - $104K *

Shape public health initiatives by overseeing medical marijuana product compliance. Collaborate across agencies, review applications, and develop procedures to ensure safety and regulatory adherence...

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$89K - $166K *

Help us drive growth as you lead a team focusing on Commercial Claims, enhancing key relationships and achieving sales objectives while managing strategic accounts and fostering talent development wit...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.