Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $122,521

Sort By: Relevance

$170K - $200K *

Champion strategic oversight of global R&D Program Management, driving agile project delivery and cross-functional alignment. Lead a diverse team to enhance portfolio operations and ensure successful...

2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$146K - $173K *

Elevate your career by joining a dynamic clinical development team, contributing to protocol development and study delivery while ensuring compliance and quality in clinical research initiatives...

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Advance clinical pharmacy services by leading initiatives that enhance medication therapy, improve patient outcomes, and foster collaboration among healthcare teams. Drive quality improvement and supp...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Drive safety initiatives and compliance programs, ensuring a secure and efficient work environment. Oversee hazardous waste management, regulatory reporting, and facility improvements while leading ac...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$160K - $220K *

Join a dynamic team as a scientific expert, driving engagement and advancing medical strategy in respiratory health. Collaborate with healthcare professionals to shape innovative therapies and improve...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $189K *

Lead cybersecurity initiatives as an Information System Security Officer, ensuring compliance and robust security controls for critical information systems while collaborating with stakeholders to saf...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $189K *

Join a team that's transforming supply chain operations through Oracle Fusion SCM. Lead the design and configuration of inventory solutions, ensuring real-time visibility and accountability for critic...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$63K - $129K *

Unlock potential by providing advanced support for Momentum Financials, collaborating with stakeholders to resolve issues, and enhancing system functionality in a dynamic environment. Bring your analy...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Innovate solutions by leveraging your expertise in data automation and systems engineering to enhance operational efficiency and support enterprise financial management systems...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $158K *

Champion quality assurance by collaborating in Agile teams to deliver robust software solutions. Leverage your testing expertise to enhance product quality and drive continuous improvement in a dynami...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Elevate your career by leveraging your expertise in business analysis to enhance Momentum Financials and Acquisitions. Collaborate with stakeholders to drive process improvements and ensure effective...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$75K - $158K *

Champion the testing of enterprise content management systems, ensuring seamless integration with SAP. Collaborate with cross-functional teams to validate workflows, enhance quality assurance, and dri...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Empower partner marketing initiatives by developing strategies that drive qualified referrals and pipeline growth across diverse partner ecosystems in North America and EMEA. Collaborate with stakehol...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Staffing

$85K - $100K *

Lead the charge in overseeing early phase clinical trials, providing statistical expertise and ensuring compliance with regulatory standards while collaborating with clients and stakeholders to delive...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Lead the charge in advancing medical initiatives, providing strategic guidance and expert consultation in cardiology, while ensuring compliance and operational excellence across project teams and medi...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Lead the charge in project management, coordinating cross-functional teams to deliver high-quality results on time and within budget while fostering stakeholder engagement and team development...

Blue Bell, PARemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Execute clinical trial management activities, ensuring quality outcomes and compliance. Collaborate with cross-functional teams, manage timelines and budgets, and build strong relationships with stake...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$89K - $149K *

Join a dynamic team as a Transportation Supervisor, leading night-shift operations. Oversee freight movement, ensure safety compliance, and develop drivers while fostering a positive culture in a larg...

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$111K - $167K *

Optimize the customer journey by leveraging analytics and strategic insights to enhance pipeline generation, forecasting, and sales enablement for a growing Property Care business. Collaborate cross-f...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$133K - $200K *

Transform your career by leading regulatory compliance for Medicaid and Medicare in the U.S. Dental Business Unit. Collaborate with cross-functional teams to enhance compliance controls and drive oper...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Lead the charge in driving sales growth and operational excellence across multiple locations. Manage a high-performing team, implement strategies, and foster customer relationships to achieve revenue...

2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$69K - $100K *

Inspire excellence in coding operations by leading a dedicated team, ensuring compliance, accuracy, and timely billing. Collaborate with stakeholders to enhance documentation quality and coding integr...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $205K *

Join a team that's redefining digital forensics by leveraging AI to enhance investigations, develop innovative tools, and engage with clients. Your expertise will drive defensible decisions and stream...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Business Services

$163K - $369K *

Lead the charge in complex software sales cycles, bridging product expertise with client needs. Engage in pre-sales activities, develop solution narratives, and enable partners to drive enterprise dea...

Reposted 2 days ago

  •   11 - 15 years exp.  •   Business Services

$132K - $271K *

Lead pre-sales efforts by delivering tailored product demos, supporting complex sales cycles, and collaborating with clients and partners to drive solution success and accelerate pipeline conversion...

Reposted 2 days ago

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.