Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,442

Sort By: Relevance

$207K - $366K *

Lead strategic account management initiatives, driving growth and client satisfaction through innovative solutions and cross-functional collaboration. Shape the future of client relationships by ensur...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Information Technology

$110K - $162K *

Transform national account growth strategies for major broker wholesale and co-op retail customers. Drive distribution expansion, enhance customer relationships, and lead profitable channel developmen...

Reposted today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$156K - $214K *

Inspire growth by leading an Enterprise CPG sales team, driving strategic partnerships with top-tier brands, and influencing C-suite executives to leverage innovative insights for impactful decisions...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Media

$130K - $190K *

Optimize product value and engineering processes by leading cross-functional teams, conducting thorough analyses, and implementing innovative solutions to enhance design, quality, and cost efficiency...

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$167K - $245K *

Drive long-term growth as a strategic leader managing key accounts in hyperscale and multi-tenant data centers. Cultivate executive relationships, align strategies, and maximize customer value through...

Reposted today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$77K - $121K *

Unlock your potential as you lead organic social strategy, engage millions, and shape brand voice across platforms. Collaborate with creative teams to drive impactful content and community engagement...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$118K - $180K *

Join a dynamic team as a senior electrical engineer, providing technical leadership in substation design and commissioning. Leverage your expertise to ensure project success through collaboration, ove...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Technical Services

$110K - $130K *

Advance operational excellence in vaccine marketing by leading speaker programs and congress activities. Collaborate across teams to ensure compliance, efficiency, and high-quality engagement, driving...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform client relationships by driving revenue growth and ensuring campaign success through strategic partnerships and effective communication. Collaborate across teams to deliver exceptional clien...

Pennsylvania, USRemote

Today

  •   5 - 7 years exp.  •   Hospitality & Recreation

$250K - $250K+*

Collaborate with faculty to support research initiatives, engage in human subject activities, and contribute to academic scholarship through presentations and papers, all while gaining valuable experi...

Today

  •   Less than 5 years exp.  •   Healthcare

$105K - $165K *

Join a team that's dedicated to enhancing AI-powered consumer features by ensuring quality, safety, and performance through innovative engineering and evaluation practices. Collaborate across departme...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Accelerate growth by leveraging your sales expertise to drive strategic deals for Unified Commerce solutions. Collaborate cross-functionally to enhance product knowledge and execute go-to-market strat...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Drive growth by owning the cross-sell pipeline, leveraging data-driven strategies to engage high-volume clients and optimize operations for maximum customer lifetime value. Collaborate with teams to d...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$104K - $166K *

Engage in delivering comprehensive home-based primary care, managing chronic diseases, and collaborating with an interdisciplinary team to enhance patient outcomes and prevent hospital visits for seni...

Today

  •   Less than 5 years exp.  •   Healthcare

$120K - $190K *

Unlock potential by leading the design and integration of advanced satellite communications systems. Drive system architecture, manage requirements, and collaborate across multi-disciplinary teams to...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$152K - $190K *

Champion innovation by leading the design and development of LIMS applications. Collaborate with stakeholders to create reliable software solutions while guiding a team of engineers in a dynamic clini...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$119K - $186K *

Champion the evolution of global AI governance and responsible data practices, ensuring compliance with regulations while driving operational efficiencies across cross-functional teams in a dynamic en...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$61K - $122K *

Optimize product delivery by bridging business needs and technical teams, leading requirement gathering, defining user stories, and ensuring alignment with stakeholders to enhance Epic EHR capabilitie...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$175K - $210K *

Unlock potential by leading corporate controllership activities, driving financial reporting, and strengthening internal controls in a rapidly evolving finance function. Collaborate with executives to...

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$115K - $172K *

Shape the future of healthcare by leading complex data ingestion initiatives. Collaborate with cross-functional teams to drive program delivery, manage risks, and ensure operational excellence while t...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$135K - $160K *

Pioneer a transformative deal desk to empower Sales with streamlined processes, enabling faster, defensible deal-making while collaborating closely with cross-functional teams to enhance pricing strat...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Drive operational excellence as you manage tech stacks and workflows, delivering data-driven insights and aligning cross-functional teams for revenue growth and partner success...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$67K - $111K *

Lead the charge in delivering compassionate, expert behavioral health care across diverse populations, ensuring continuity and support throughout each member's wellness journey while leveraging clinic...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$240K - $270K *

Elevate your career by leading the Sports and Entertainment vertical across North America. Drive customer acquisition and revenue growth through consultative selling and technical expertise, shaping t...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Transform the ScriptMed Cloud Platform by designing and deploying scalable solutions. Collaborate with teams to automate workflows and enhance customer onboarding while ensuring compliance with data s...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.