Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,477

Sort By: Relevance

$83K - $95K *

Join a team that's shaping the future of nursing education by teaching innovative online Pediatrics courses. Engage students with cutting-edge methodologies and foster a vibrant online learning cultur...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$98K - $130K *

Drive financial excellence by leading cost accounting operations, ensuring accurate reporting and analysis. Collaborate across departments to support strategic business decisions and contribute to tim...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Aerospace & Defense

$195K - $264K *

Drive global regulatory strategies for obesity and cardiometabolic disorders, ensuring alignment across teams and leading interactions with health authorities. Leverage scientific expertise to navigat...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$217K - $294K *

Innovate the U.S. Cardiovascular & Metabolic Medical strategy, leading evidence generation and stakeholder engagement for chronic weight management. Collaborate cross-functionally to ensure launch rea...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$81K - $151K *

Drive procurement excellence by developing subcontract specifications and managing the entire subcontract lifecycle, ensuring compliance and fostering strong supplier relationships to support diverse...

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

$146K - $215K *

Transform operations by partnering with plant leadership to drive IT excellence, ensuring digital solutions enhance productivity and stability across manufacturing and supply chain processes in North...

Today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Lead the charge in managing multi-state environmental reclamation projects, ensuring regulatory compliance and technical excellence. Collaborate with multidisciplinary teams to deliver impactful solut...

Reposted today

  •   11 - 15 years exp.  •   Technical Services

$120K - $135K *

Elevate our proposal management efforts by leading strategic submissions, fostering collaboration among teams, and enhancing our pursuit capabilities to secure high-value projects that improve infrast...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Technical Services

$150K - $165K *

Transform client relationships by driving revenue growth and satisfaction in healthcare accounts. Collaborate with stakeholders to develop tailored strategies, ensuring long-term partnerships and meas...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

$86K - $138K *

Lead the charge in defining and executing a comprehensive product strategy, driving value across product portfolios. Collaborate with key stakeholders to align strategic vision while overseeing perfor...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$134K - $223K *

Lead digital web projects, ensuring optimal performance and compliance across the GSK.com platform. Collaborate with cross-functional teams to enhance user experience, mitigate cybersecurity risks, an...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the charge in delivering complex renewable energy projects, ensuring safety, quality, and budget adherence. Collaborate with diverse stakeholders to drive project success from development through...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Energy & Utilities

$76K - $97K *

Elevate data literacy by facilitating engaging workshops and training sessions. Collaborate with diverse stakeholders to enhance understanding of data analytics, fostering a culture of learning and in...

Today

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Lead strategic initiatives in athletics to enhance student-athlete success, foster a collaborative culture, and manage operations for 23 NCAA Division III sports, ensuring alignment with university go...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$90K - $100K *

Join a team that's driving franchise sales success by leading, coaching, and developing a high-performing sales team. Optimize processes, leverage analytics, and collaborate across departments to enha...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Hospitality & Recreation

$80K - $95K *

Elevate your career as a Senior Accountant, driving day-to-day operations and enhancing internal processes. Collaborate with teams to transition activities, ensuring accuracy and scalability in a fast...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Execute multi-channel marketing campaigns, driving results through strategic planning and collaboration. Own project timelines and coordinate teams to enhance player engagement in the crypto and iGami...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Consumer Technology

$135K - $165K *

Drive customer success in Cancer Registry by building relationships, enhancing retention, and translating insights into actionable solutions. Collaborate across teams to improve outcomes and shape bus...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$168K - $214K *

Drive the development of advanced on-vehicle communication systems and diagnostics for autonomous vehicles, ensuring safety and performance at fleet scale while collaborating with a dynamic team of en...

Today

  •   Less than 5 years exp.  •   Transportation

$168K - $214K *

Join a dynamic team to build innovative on-vehicle communication frameworks and enhance autonomous vehicle safety through advanced software solutions and monitoring systems...

Pittsburgh, PARemote

Today

  •   Less than 5 years exp.  •   Transportation

$80K - $95K *

Drive strategic sales initiatives by engaging with electrical distributors and end users to secure large project opportunities, ensuring alignment and collaboration across teams for successful project...

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$96K - $210K *

Join a team that's dedicated to providing tailored financial strategies for senior executives. As a trusted advisor, you'll enhance client relationships and drive business growth through personalized...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$115K - $120K *

Innovate solutions for time capture and billing in a dynamic team. Leverage AI tools to enhance software development, ensuring accuracy and efficiency in invoicing processes while collaborating across...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

$80K - $96K *

Join a team that's driving automation and digital transformation in government and defense. Leverage your RPA expertise to design, develop, and deploy innovative solutions while collaborating with div...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$74K - $91K *

Contribute to national health data collection efforts by leveraging your nursing expertise and survey research skills. Engage in participant-centered data collection, quality control, and training whi...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.