Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Oncologist Jobs in South Dakota

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$95K - $115K *

Drive provider network excellence by managing data integrity, overseeing contract configurations, and leading cross-functional teams to enhance operational efficiency and compliance in a dynamic TPA e...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$220K - $255K *

Shape the future of healthcare by leading strategic payor relationships and driving reimbursement strategies. Collaborate cross-functionally to enhance patient access and optimize coverage for innovat...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Elevate client relationships as a strategic leader, driving retention and growth. Collaborate with cross-functional teams to deliver exceptional service and develop high-performing teams focused on cl...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$185K - $344K *

Advance enterprise patient intelligence by leading strategy, governance, and analytics. Collaborate across functions to enhance decision-making and drive insights that improve patient outcomes and bus...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$108K - $200K *

Champion the resolution of complex commercial casualty claims by delivering exceptional customer service, conducting thorough investigations, and collaborating with defense counsel to ensure fair outc...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$101K - $197K *

Empower your career by leading global regulatory strategies for medical devices and diagnostics. Collaborate with cross-functional teams to ensure compliance and drive market access while mentoring ot...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$250K - $350K *

Drive strategic account management in a hybrid role, fostering relationships with clinical stakeholders to enhance client engagement and expand revenue through trusted partnerships and targeted soluti...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $120K *

Accelerate progress at the intersection of media and healthcare by leading integrated planning and strategy for pharmaceutical clients. Drive impactful engagement initiatives while mentoring a talente...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$96K - $120K *

Partner with cross-functional teams to drive successful integrations, ensuring best practices and client satisfaction. Become the internal expert on data management while leading technical relationshi...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$135K - $165K *

Pioneer operational excellence in Design leadership, managing workflows, prioritizing projects, and developing talent. Collaborate cross-functionally to enhance Design integration in AI-driven product...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to enhancing client experiences through exceptional facility management. Oversee multiple locations, collaborate on strategic initiatives, and ensure a welcoming atmospher...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$108K - $148K *

Join us as a Senior FP&A Analyst to drive financial planning, reporting, and forecasting. Collaborate across teams to optimize spending and enhance our financial systems, leveraging AI for insights th...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$84K - $127K *

Manage and enhance database operations, ensuring security and performance. Collaborate with teams to develop innovative solutions and maintain integrity controls while contributing to policy formulati...

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$125K - $150K *

Champion growth by building strategic relationships and driving sales in the Healthcare sector. Leverage AI solutions to enhance customer engagement and achieve revenue targets while collaborating wit...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $185K *

Elevate the legal landscape by leveraging AI to transform workflows. Collaborate with law firms to design and implement innovative solutions, ensuring successful adoption of advanced legal technologie...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$300K - $350K *

Join a dynamic team as you lead enterprise sales cycles, driving growth and establishing a strong presence in Conversational AI. Your expertise will influence strategy and secure high-impact deals wit...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$70K - $100K *

Join a dynamic team to drive profitable business through strategic underwriting and broker partnerships. Leverage your expertise to enhance client relationships and contribute to innovative solutions...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Lead cross-functional project execution in Medication Contracting, translating strategic priorities into actionable plans. Drive improvements, manage risks, and enhance collaboration across teams to e...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Take ownership of patient care by assessing, diagnosing, and treating individuals. Collaborate with physicians to develop care plans, educate patients, and ensure quality health services in a supporti...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$71K - $106K *

Join a team that crafts compelling pitches and proposals for client-focused opportunities. Collaborate across business units in a dynamic environment, driving innovative solutions and business develop...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$162K - $224K *

Transform healthcare operations by leveraging your expertise to drive efficiency and improve outcomes. Engage with clients to analyze needs, manage projects, and lead teams in delivering sustainable p...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$180K - $230K *

Join a dynamic team as you lead engineering efforts to develop an AI Patient Engagement Agent, transforming clinical trials by automating patient interactions and enhancing operational efficiency for...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$138K - $183K *

Lead the development and execution of patient support strategies to enhance access and engagement for oncology therapies, collaborating cross-functionally to optimize promotional initiatives and drive...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$217K - $271K *

Launch your career by owning the national Field Excellence model, managing operations for a groundbreaking oncology therapy. Collaborate with sales leaders to enhance prescriber access and streamline...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$68K - $113K *

Lead the charge in optimizing coding accuracy and compliance by analyzing complex patient care documentation, providing expert guidance, and enhancing coder education to ensure adherence to ethical st...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.