Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$80K - $95K *
Drive customer satisfaction and growth by nurturing relationships, identifying upsell opportunities, and collaborating on account strategies. Leverage industry insights to maximize account potential a...
4 weeks ago
Operations Manager, Global Strategic Accounts
$130K - $160K *
Drive operational excellence by leading a global team to deliver high-quality wellbeing programs. Collaborate with stakeholders to ensure effective execution, maintain standards, and enhance participa...
2 weeks ago
$330K - $390K *
Join a team that's driving enterprise-level strategic statistical leadership across Biostatistics. You'll oversee programs, mentor statisitians, and ensure collaboration for successful drug developmen...
Reposted 3 weeks ago
Quality Operations Manager (Contract)
$100K - $120K *
Contribute to quality operations initiatives by reviewing study documents, supporting audits, and ensuring compliance with regulatory standards. Collaborate with cross-functional teams to enhance qual...
5 days ago
Senior Oracle Functional Analyst
$79K - $194K *
Champion the standardization of financial posting logic across Oracle EBS, ensuring compliance and audit readiness. Collaborate with cross-functional teams to enhance federal financial processes and s...
1 week ago
$95K - $115K *
Elevate customer success by guiding clients through their journey, maximizing product value, and fostering strategic partnerships. Collaborate cross-functionally to enhance user experience and drive r...
3 weeks ago
Program Management Office (PMO) Analyst
$73K - $132K *
Support commercial airport contracts by assisting project managers with requirements gathering, SOW generation, and project execution. Contribute to back-office operations and ensure timely invoicing...
Today
Account Specialist (Macon, GA)
$160K - $192K *
Inspire commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring impactful re...
5 days ago
$150K - $180K *
Unlock potential by leading enterprise sales initiatives, managing complex accounts, and driving strategic growth. You will navigate technical discussions and deliver value-driven solutions to top-tie...
3 weeks ago
Senior Consultant - Grants Lifecyle Process Improvement
$98K - $163K *
Optimize federal grants management operations by assessing processes, identifying inefficiencies, and delivering actionable recommendations. Collaborate with stakeholders to enhance program outcomes a...
3 weeks ago
$69K - $125K *
Transform regulatory insights into actionable strategies by analyzing national and state legislative activities. Collaborate with legal and business teams to ensure compliance and support effective de...
2 weeks ago
Key Account Director, Corrections
$144K - $200K *
Help us lead a national sales team focused on public safety solutions. Drive recruitment, coaching, and team performance to enhance sales effectiveness in the corrections sector, while collaborating a...
1 week ago
Clinical Research Associate-CRA I/II - FSP
$80K - $95K *
Join a dynamic team as you manage clinical research sites, ensuring compliance and quality throughout all study phases. Build strong relationships, oversee monitoring activities, and contribute to tea...
3 weeks ago
Transformation Consultant, Professional Services
$74K - $137K *
Lead the charge in transforming workflows with AI, driving adoption and measurable impact in legal, tax, and trade sectors. Collaborate with clients and teams to design, implement, and evaluate innova...
2 weeks ago
Nurse Practitioner or Physician Assistant | Hospitalist
$90K - $110K *
Lead the delivery of comprehensive medical care by assessing, diagnosing, and treating patients. Collaborate with healthcare teams to enhance patient education and ensure quality care while adhering t...
2 days ago
Manager, Complex Clinical Denials
$100K - $120K *
Drive impactful projects by collaborating across teams to enhance operational efficiency and deliver innovative solutions. Leverage your expertise to influence strategic decisions and contribute to a...
2 days ago
Senior Advisor, Regulatory Starting Material
$153K - $268K *
Join a team that's advancing regulatory strategies for drug substance manufacturing. Lead the charge in selecting and justifying Regulatory Starting Materials, ensuring compliance with global guidelin...
Reposted 1 week ago
Senior Backend Engineer, External
$199K - $235K *
Innovate backend solutions by designing, building, and maintaining scalable services for external pentesting. Collaborate across teams to enhance user experience and ensure system performance, reliabi...
1 week ago
Senior Manager, Finance & Strategy - Go-To-Market
$183K - $228K *
Drive strategic financial insights as a key partner to the go-to-market teams, owning revenue forecasts and investment economics. Collaborate with leadership to shape long-term growth strategies and e...
Reposted 3 weeks ago
$80K - $95K *
Support project management by coordinating study documentation, mentoring team members, and ensuring compliance. Leverage expertise in clinical research to enhance study start-up and execution, while...
1 week ago
Key Account Manager - San Francisco, CA
$170K - $205K *
Drive sales growth by developing strategic account plans, fostering relationships with healthcare professionals, and navigating complex environments to ensure product access and utilization in the kid...
3 weeks ago
Senior / Principal Due Diligence Growth Lead
$125K - $150K *
Lead strategies to drive environmental due diligence growth, manage key client relationships, oversee project execution, and ensure delivery of high-quality results through effective team leadership a...
Reposted 2 weeks ago
Cardiovascular Account Specialist - U.S. Sales, San Antonio, TX
$162K - $195K *
Take ownership of driving sales performance in your territory by launching a novel cardiac myosin inhibitor. Collaborate with internal teams and external stakeholders to build strategic relationships...
1 week ago
Senior Construction Underwriter
$94K - $164K *
Empower your career by managing a profitable middle-market construction book. Leverage your E&S underwriting expertise to build relationships, identify opportunities, and drive growth with minimal sup...
1 week ago
Case Review Manager - Independent Reviews (IRO/UR)
$85K - $95K *
Oversee the quality assurance of case reviews, ensuring accuracy and completeness in documentation while collaborating with clinicians to uphold high standards in healthcare determinations and workflo...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.