Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Oncologist Jobs in South Dakota

Sort By: Relevance

$223K - $233K *

Deliver strategic leadership in biologics process development, overseeing outsourced manufacturing and ensuring alignment with corporate goals while driving technical excellence in late-stage developm...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$130K - $216K *

Join a dynamic team to lead technology consulting projects in biopharma, ensuring successful implementation of patient services solutions. Collaborate with clients and cross-functional teams to drive...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$225K - $324K *

Accelerate growth by leading global enablement initiatives that empower sellers, engineers, and partners. Drive strategic programs, enhance skills, and ensure readiness for a multi-product platform in...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$80K - $110K *

Transform financial operations by providing analytical support, enhancing reporting processes, and collaborating with cross-functional teams to drive profitability and efficiency in budgeting and fore...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$150K - $215K *

Champion strategic sales initiatives by leading a high-performing pod, driving complex SaaS partnerships with top law firms, and fostering executive-level relationships to enhance client engagement an...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$110K - $130K *

Empower transformative telehealth solutions by designing and implementing robust software infrastructure. Join a dynamic team to innovate, automate, and streamline applications, impacting the healthca...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$194K - $242K *

Unlock potential by leading product marketing strategies in GLP-1 and cardiometabolic health. Collaborate with cross-functional teams to enhance buyer clarity and sales effectiveness, while coaching a...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$173K - $320K *

Shape the future of rheumatology by providing strategic medical oversight across clinical trials. Lead the innovation and development of groundbreaking therapies while collaborating with multidiscipli...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive your career with a pivotal role in CMC regulatory affairs, ensuring compliance for biologics and small molecules. Collaborate across teams to prepare high-quality submissions and strategies, imp...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Drive the M&A strategy by leading the full transaction lifecycle, from sourcing to integration. Collaborate with executive leadership to identify growth opportunities that enhance enterprise value and...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $160K *

Analyze complex data and drive solutions as a Business Analyst in the public sector. Leverage your expertise in pension systems to identify issues and enhance processes, ensuring effective communicati...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$225K - $265K *

Transform healthcare interoperability by leading product strategy and market growth. Leverage deep industry insights to enhance payer-provider collaboration, drive operational excellence, and oversee...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $105K *

Join a dynamic team to coordinate supplier management, drive contract workflows, and ensure compliance in clinical studies. Collaborate with cross-functional teams to enhance supplier processes and su...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$73K - $111K *

Empower patient care by performing specialized interventional radiology procedures. Collaborate with medical teams to ensure optimal outcomes while maintaining high standards of safety and quality in...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$150K - $240K *

Optimize coding workflows by leveraging your 10+ years of leadership in coding, compliance, and revenue cycle management. Collaborate with AI and engineering teams to drive innovation and enhance oper...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Drive financial accuracy and compliance as a Senior Accountant. Lead month-end close, maintain internal controls, and support auditors while refining processes. Ideal for proactive self-starters seeki...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$215K - $240K *

Shape the future of commercial operations by leading strategy, workflows, and data integration. Collaborate with senior leaders to enhance brand performance and drive operational excellence across cro...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$133K - $237K *

Contribute to patient safety by overseeing medical product surveillance, analyzing data, and ensuring compliance with regulations. Collaborate on risk management and support clinical studies to enhanc...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Transform healthcare through innovative AI deployments. As a key technical expert, you'll develop and implement cutting-edge systems that enhance clinical workflows and optimize patient interactions...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $120K *

Shape your career as you take ownership of key accounts, driving sales and building relationships. Collaborate with top performers to modernize government services, while gaining invaluable experience...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$139K - $163K *

Advance your career as a strategic legal partner by providing product and privacy counsel that balances compliance with innovation. Collaborate across teams to develop scalable solutions that support...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $185K *

Shape strategic success for key accounts by leading market access initiatives, collaborating with cross-functional teams, and driving growth through innovative solutions and insights in the managed ma...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$170K - $220K *

Shape the future of customer solutions by leading implementations and driving adoption of innovative technologies. Collaborate with teams to deliver tailored architectural designs that meet strategic...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $195K *

Drive the development and execution of strategic projects for radioisotope production facilities. You will lead cross-functional teams to ensure operational readiness, regulatory compliance, and succe...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$125K - $140K *

Optimize your career by managing enterprise-wide database environments, ensuring high availability, executing disaster recovery strategies, and supporting critical operations in a dynamic SaaS ecosyst...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.