Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Manager, Market Access and Reimbursement - North Central
$136K - $170K *
Partner with us to enhance patient access by leading market access strategies, educating teams, and collaborating across departments to ensure effective reimbursement for our innovative medical techno...
4 weeks ago
Customer Advocacy Marketing Manager
$90K - $124K *
Unlock potential by leading customer advocacy initiatives, driving content strategy, and managing high-volume production of case studies and testimonials. Collaborate with cross-functional teams to en...
4 weeks ago
MGR, Contracting - Health Plan Relations (West Region)
$95K - $115K *
Drive managed care contracting activities, supporting payer negotiations and relationships. Collaborate with leadership to execute center-level priorities and enhance client satisfaction through effec...
1 week ago
Manager, Applications, Epic Orders
$165K - $264K *
Pioneer cross-functional collaboration to manage IS projects, ensuring successful implementation and support of applications, upgrades, and integrations while overseeing budgets and resources across S...
2 days ago
$95K - $115K *
Champion healthcare solutions by managing integrations and providing expert support. Drive projects and improve processes as a Senior Interface Analyst in a dynamic and innovative environment, ensurin...
Reposted 5 days ago
Account Specialist, Gainesville-Daytona Beach, FL
$160K - $192K *
Accelerate commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to optimize patient access and support innovative therapies in a dy...
1 week ago
Senior Site Identification and Relationship Manager - US/Mexico City/Argentina - Remote
$90K - $178K *
Drive post-award site identification efforts by developing strategies, managing feasibility questionnaires, training resources, and coordinating outreach to ensure optimal site activation and client c...
Reposted 1 week ago
Sr. Technical Product Manager, AI & Analytics
$116K - $193K *
Lead the charge in defining and executing the product strategy for AI and analytics, driving innovation across pharmacy management platforms. Collaborate with cross-functional teams to deliver scalabl...
4 weeks ago
$104K - $166K *
Join a team that's dedicated to enhancing cybersecurity operations. As a Senior SOC Analyst, you'll monitor threats, analyze network traffic, and lead incident response efforts while mentoring junior...
2 days ago
$104K - $166K *
Join a team that's dedicated to enhancing cybersecurity operations by monitoring, analyzing, and responding to security incidents. Leverage your expertise to protect critical systems and mentor junior...
1 week ago
Senior Service Desk Technician
$120K - $150K *
Unlock a seamless end-user experience by overseeing technical support, mentoring, and cross-functional collaboration in a dynamic IT environment dedicated to operational excellence and service improve...
Reposted 1 week ago
ED, Advance Analytics and Precision Health
$225K - $418K *
Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...
2 days ago
Account Executive - Government
$80K - $95K *
Grow your career by developing and maintaining key customer relationships, driving sales success, and collaborating with teams to exceed goals. Leverage your expertise in account management and sales...
2 weeks ago
$78K - $128K *
Lead the product lifecycle for health plans, driving strategy, development, and market alignment. Collaborate with cross-functional teams to enhance offerings and ensure compliance, while identifying...
Reposted 2 days ago
Sys VP Clinical and Industry Trials
$180K - $220K *
Empower innovation in clinical trials by developing strategies, overseeing operations, and cultivating partnerships. Drive excellence in research, enhance compliance, and manage a high-performing team...
Reposted 1 week ago
Director, Intelligence Planning & Execution
$185K - $344K *
Join a dynamic team driving strategic planning and performance management across analytics capabilities. Lead portfolio governance and execution initiatives to align resources and priorities, ensuring...
2 days ago
Corporate Charge Capture Auditor, Outpatient
$63K - $101K *
Optimize compliance in Interventional Radiology charge capture by conducting audits, educating teams, and enhancing coding practices. Collaborate with clinical departments to identify and rectify codi...
3 weeks ago
$82K - $90K *
Empower successful RHTP initiatives through stakeholder engagement, communications, and project support. Collaborate with diverse teams to ensure effective outreach, timely execution, and inclusive pa...
3 weeks ago
$150K - $180K *
Elevate client relationships by managing strategic Tier 1 accounts, driving revenue growth, and ensuring customer satisfaction. Collaborate cross-functionally to develop account strategies and deliver...
4 weeks ago
$120K - $145K *
Join a team that's transforming medicine by engaging with KOLs and healthcare professionals. Leverage your clinical expertise to communicate product benefits, support education, and drive strategic in...
Reposted 5 days ago
$80K - $92K *
Drive the resolution of technical support escalations as a key Tier 2 expert, leveraging your skills to troubleshoot issues, foster collaboration within teams, and enhance workflows in a dynamic envir...
Reposted today
Regulatory Submissions Lead II
$110K - $130K *
Lead and execute regulatory strategies for multi-region clinical trials, ensuring compliance and timely submissions. Collaborate with project teams to manage risks and drive operational excellence thr...
5 days ago
$99K - $118K *
Transform your career by leveraging your clinical and coding expertise to defend appeals for healthcare claims. This role demands independent analysis, strong communication, and proficiency in AI tool...
1 week ago
$120K - $145K *
Lead the charge in database operations, ensuring optimal performance and security for mission-critical systems. Oversee a technical team while aligning with federal standards and integrating with deve...
1 week ago
Director, Client Strategy and Growth
$185K - $210K *
Engage with clients to drive retention and growth strategies, fostering deep relationships and collaboration across teams. Leverage market insights to enhance product offerings and ensure client succe...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.