Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Oncologist Jobs in South Dakota

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$100K - $120K *

Join a team that's focused on enhancing client delivery and relationship growth. Drive data-driven strategies and cross-functional collaboration to optimize post-sale operations, ensuring exceptional...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$123K - $169K *

Unlock your potential by providing expert clinical training and support to customers, ensuring they effectively operate advanced dosimetry equipment. Collaborate with cross-functional teams to enhance...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$101K - $152K *

Champion innovative solutions by leveraging Epic expertise to enhance operational efficiency and drive strategic initiatives across healthcare environments, ensuring high-performance standards and cli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$143K - $200K *

Innovate solutions as a Senior Appian Developer, tackling complex BPM challenges. Collaborate with teams to design, implement, and optimize high-performance applications while mentoring junior develop...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Drive analytical solutions by leading projects, applying advanced data analysis, and collaborating with clients to deliver actionable insights across energy initiatives including efficiency and sustai...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$70K - $110K *

Join a team that's dedicated to supporting disaster recovery efforts. Collaborate with leadership and clients to navigate complex recovery operations, ensuring effective management of multi-billion do...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Business Services

$170K - $185K *

Join a dynamic team to define and lead product strategy for Family Building Navigation, enhancing member engagement through innovative digital experiences and personalized support while collaborating...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$191K - $305K *

Champion innovative healthcare solutions by leveraging clinical expertise to enhance value-based strategies, drive operational excellence, and foster strategic partnerships for improved member care an...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $140K *

Shape the future of customer success by managing strategic relationships, driving product adoption, and ensuring high-value outcomes for complex customer accounts. Collaborate with cross-functional te...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$155K - $160K *

Drive the Order-to-Cash strategy, overseeing cash application, collections, and AR performance. Collaborate cross-functionally to optimize cash flow and enhance financial reporting, ensuring timely re...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Join a team that's dedicated to ensuring compliance and quality in site contracts. Manage negotiations, oversee contract processes, and collaborate with clients and experts to deliver timely and effec...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$126K - $154K *

Unlock your potential as a Senior Accountant, driving financial accuracy and compliance. Collaborate across teams to enhance systems, oversee key accounting functions, and support audits in a dynamic...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Grow your career with a dynamic team focused on residential mortgage origination. Lead initiatives to develop talent, manage loan processes, and ensure exceptional customer experiences while achieving...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Deliver exceptional client engagement by managing relationships and driving growth within a diverse portfolio. Collaborate with teams to maximize retention and uncover new opportunities, ensuring clie...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$100K - $120K *

Champion the adoption of MRD testing services by engaging clinicians and stakeholders, driving strategic business development, and maximizing client relationships within major cancer centers and healt...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a dynamic team to drive sales of innovative laboratory equipment in the Northeast. Engage with clients, deliver product demos, and exceed sales targets while fostering strong relationships and pr...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$68K - $105K *

Help us lead enterprise-wide incident responses and internal investigations into misconduct, ensuring compliance and effective fraud detection while collaborating across departments to uphold organiza...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$99K - $138K *

Champion innovative solutions as you drive partner adoption of our lending platform. Collaborate across teams to analyze deal economics and translate insights into actionable strategies that enhance p...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Explore advanced revenue analysis and month-end controls to ensure accurate invoicing and financial reporting. Collaborate across functions to resolve discrepancies, mentor junior analysts, and drive...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Accelerate your career by driving growth in healthcare sales. Leverage your expertise to build relationships with key accounts, navigate complex deals, and shape future services that impact the indust...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$78K - $131K *

Contribute to the development and administration of competitive compensation programs, ensuring alignment with organizational strategy. Lead projects and provide consultation to HR partners while main...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$82K - $110K *

Champion grant proposal excellence by collaborating with clients to enhance competitiveness in scientific research funding. Drive impactful outcomes through expert consulting, training, and proposal d...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$239K - $358K *

Join a team that's committed to maximizing growth in pharmaceutical accounts through strategic planning and relationship building, focusing on data-driven solutions and real-world evidence to foster l...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Transform claims management by leading strategic initiatives, overseeing operations, and driving continuous improvement across a diverse portfolio, ensuring optimal outcomes and compliance while colla...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$180K - $220K *

Drive the enterprise data strategy and governance, ensuring data quality, compliance, and accessibility. Lead cross-functional teams to foster a data-rich culture, enabling advanced analytics and AI r...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.