Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$110K - $130K *
Manage and lead field-based medical teams, ensuring client delivery and team performance while fostering scientific engagement and program growth. Collaborate with cross-functional teams to achieve st...
3 weeks ago
Director, Business Development
$150K - $180K *
Unlock new opportunities as you drive business growth in the life sciences sector. Focus on building relationships and matching client needs with innovative solutions in commercial consulting, brand c...
Reposted 4 weeks ago
Director Advisory Services Analytics Delivery and Data Engineering
$141K - $234K *
Lead the charge in healthcare performance improvement by overseeing project delivery, managing client relationships, and mentoring a team of Advisory consultants to ensure successful, high-quality out...
Reposted 4 days ago
RCM Regional Sales Manager, Strategic
$110K - $130K *
Accelerate progress at the forefront of healthcare sales by driving revenue growth and expanding strategic partnerships in the RCM sector. Lead comprehensive sales strategies to engage large clients a...
3 weeks ago
Triage Clinical Guide (Registered Nurse) – Night Shift
$95K - $110K *
Partner with us to transform healthcare delivery by providing telephonic clinical triage and support. You'll advocate for members, ensuring they receive timely care while collaborating with a dedicate...
Yesterday
Managing Consultant - Clinical Documentation Integrity (CDI) - Healthcare
$120K - $165K *
Drive the successful transfer of CDI best practices by mentoring client teams, conducting record reviews, and delivering education. Collaborate with healthcare professionals to enhance documentation a...
4 weeks ago
$150K - $195K *
Elevate client relationships by managing key accounts, driving satisfaction and growth. Collaborate with internal teams to deliver tailored solutions, ensuring long-term success and measurable ROI for...
3 weeks ago
Sr Manager Financial Planning and Analysis
$125K - $150K *
Lead the Corporate FP&A function, overseeing forecast consolidation, monthly reporting, and financial analysis. Collaborate with finance and business partners to ensure accuracy and transparency in fi...
2 weeks ago
$110K - $130K *
Join a team that's redefining product management by leading AI and automation initiatives. Drive strategic roadmaps, enhance operational efficiency, and deliver impactful solutions while collaborating...
2 days ago
$102K - $120K *
Lead the charge in driving product strategy and execution for AI applications, ensuring high-quality delivery and alignment with business outcomes. Collaborate with cross-functional teams to optimize...
3 weeks ago
$88K - $140K *
Shape the future of public service by leading technology consulting projects that enhance operational efficiency and strategic goals for state and local agencies, ensuring compliance and delivering im...
2 weeks ago
Director, Diagnosis-Related Group Validation (DRGV)
$125K - $150K *
Unlock your potential by leading the development of innovative DRGV services, enhancing billing and coding optimization. Collaborate across teams to create scalable solutions that drive operational ex...
2 weeks ago
Director / Senior Director / Executive Director, Regulatory Affairs
$210K - $275K *
Transform regulatory affairs in oncology by leading strategic submission initiatives and cross-functional collaborations, ensuring compliance and quality for impactful development programs. Drive regu...
Reposted 1 week ago
Client Success Executive - Prescription Benefits
$80K - $95K *
Drive client success by leading strategic account teams, ensuring satisfaction, and fostering strong relationships. Leverage expertise to enhance service delivery and support client retention through...
Reposted 2 days ago
Prin Div Strategy Consultant - Governance (Remote)
$92K - $167K *
Drive compliance and contractor support in contracting standards, regulatory adherence, and policy execution. Work collaboratively across departments to provide strategic guidance, ensuring alignment...
Reposted yesterday
$110K - $165K *
Drive impactful clinical and technical research initiatives across global teams, ensuring project success from planning to execution. Collaborate with cross-functional partners to meet quality, budget...
Yesterday
$101K - $146K *
Unlock potential by leading payer contract negotiations to enhance relationships, optimize revenue, and ensure compliance with regulations, all while aligning with strategic priorities of the health s...
3 weeks ago
Clinical System Programmer Developer (Allscripts/MLM)
$87K - $157K *
Join a dynamic team to develop and enhance clinical systems, ensuring compliance with NIH standards. Collaborate with cross-functional teams to troubleshoot and implement solutions that improve health...
1 week ago
Manager, Client Strategy & Operations
$100K - $120K *
Join a team that's focused on enhancing client delivery and relationship growth. Drive data-driven strategies and cross-functional collaboration to optimize post-sale operations, ensuring exceptional...
Reposted 2 weeks ago
Clinical Applications Specialist - Dosimetrist (Travelling position)
$123K - $169K *
Unlock your potential by providing expert clinical training and support to customers, ensuring they effectively operate advanced dosimetry equipment. Collaborate with cross-functional teams to enhance...
1 week ago
Senior Product Manager, Epic Optimization
$101K - $152K *
Champion innovative solutions by leveraging Epic expertise to enhance operational efficiency and drive strategic initiatives across healthcare environments, ensuring high-performance standards and cli...
1 week ago
$143K - $200K *
Innovate solutions as a Senior Appian Developer, tackling complex BPM challenges. Collaborate with teams to design, implement, and optimize high-performance applications while mentoring junior develop...
2 weeks ago
$80K - $95K *
Drive analytical solutions by leading projects, applying advanced data analysis, and collaborating with clients to deliver actionable insights across energy initiatives including efficiency and sustai...
4 weeks ago
$70K - $110K *
Join a team that's dedicated to supporting disaster recovery efforts. Collaborate with leadership and clients to navigate complex recovery operations, ensuring effective management of multi-billion do...
Reposted 2 days ago
$170K - $185K *
Join a dynamic team to define and lead product strategy for Family Building Navigation, enhancing member engagement through innovative digital experiences and personalized support while collaborating...
6 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.