Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Oncologist Jobs in South Dakota

Sort By: Relevance

$94K - $130K *

Elevate product outcomes by collaborating with teams to prioritize and define user stories, ensuring alignment with business needs while maximizing value delivery and maintaining product quality throu...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Take ownership of financial and operational analysis for strategic initiatives, delivering critical insights and reporting to support executive decision-making while driving accuracy and efficiency in...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Elevate healthcare through strategic AI product management, driving innovation and lifecycle management of AI solutions. Collaborate cross-functionally to align business objectives with customer needs...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$350K - $398K *

Drive impactful clinical trials in ophthalmology with leadership in study design, execution, and biomarker strategy. Collaborate cross-functionally to ensure timely delivery and regulatory compliance...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$72K - $192K *

Join a team that's dedicated to enhancing client relationships in healthcare. As a trusted advisor, you'll guide clients through workflows, drive feature adoption, and develop strategic plans to maxim...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$119K - $134K *

Partner with us to enhance patient care by supporting primary care teams remotely. Collaborate with on-site providers to manage patient needs effectively, ensuring seamless communication and coordinat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $150K *

Champion continuous improvement initiatives by optimizing processes and products across the organization. Lead cross-functional teams to enhance operational efficiency, quality, and customer experienc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$104K - $143K *

Empower healthcare transformation by developing strategic initiatives that enhance operational efficiency and clinician productivity. Collaborate cross-functionally to drive impactful solutions and im...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Unlock potential by managing pharmacy operations, supervising staff, and ensuring compliance. Cultivate leadership crucial for team growth and efficient workflow while delivering exceptional patient c...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$68K - $105K *

Champion the implementation and support of Epic Beaker applications, ensuring effective system design, user experience, and problem resolution while managing projects and enhancing end-user engagement...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $125K *

Elevate virtual health services by leading strategic initiatives, enhancing patient experiences, and driving operational excellence. Collaborate across teams to implement innovative care models and en...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Partner with us to enhance client relationships and drive growth. In this role, you'll manage a diverse portfolio, ensuring customer retention and identifying new opportunities while collaborating wit...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$120K - $145K *

Lead the charge in driving client success by building trusted partnerships, understanding client objectives, and ensuring seamless delivery of services. Collaborate with internal teams to enhance sati...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$138K - $198K *

Innovate financial strategies as a key partner in FP&A, driving insights and accountability across R&D and G&A. Own financial models, forecasts, and planning processes to support strategic decision-ma...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$138K - $186K *

Unlock your potential as a principal technical leader for enterprise Unix and Linux platforms, driving architecture, automation, and lifecycle management to deliver resilient infrastructure for critic...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$86K - $118K *

Join a team that's dedicated to enhancing consumer experiences through innovative solutions. Leverage your technical expertise in a collaborative environment focused on continuous improvement and impa...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$101K - $137K *

Contribute to transactional finance activities across the procure-to-pay lifecycle, ensuring accurate processing of financial transactions while supporting operational workflows and maintaining data i...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Lead the charge in driving enterprise growth within healthcare by building relationships with national and regional health plans. Own new logo acquisition and expansion, leveraging a robust support sy...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$102K - $120K *

Join a team that's transforming healthcare analytics by bridging complex data with strategic insights. Leverage your SQL expertise and analytics engineering skills to empower stakeholders and drive va...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $180K *

Join a team that's driving growth in Life Sciences by managing key client relationships and delivering innovative solutions. You'll oversee the entire sales process, collaborating with experts to achi...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Unlock compensation strategies by partnering with teams to analyze, model, and deliver data-driven solutions. Drive benchmarking, job architecture, and annual comp cycles to ensure equitable pay pract...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Champion global physical security and resiliency initiatives by providing strategic leadership to enhance safety for employees and assets while driving compliance across all company operations and thi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$156K - $211K *

Unlock your potential as a Senior Machine Learning Engineer, driving innovative AI solutions. Collaborate with cross-functional teams to develop scalable prototypes, translating complex business needs...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$79K - $139K *

Join a team that's dedicated to driving excellence in clinical trial contracts. As a Senior Site Contracts Manager, you'll negotiate and manage site budgets and agreements, collaborating with key stak...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$58K - $105K *

Unlock your potential by managing the full contracting lifecycle, supporting critical agreements for Medicare Advantage and Commercial operations, while collaborating with diverse teams to enhance com...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.