Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Oncologist Jobs in South Dakota

Sort By: Relevance

$130K - $150K *

Join a dynamic team to design and develop innovative mobile solutions across Android and iOS. Take ownership of projects, collaborate with peers, and contribute to the broader tech stack while enhanci...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Legal & Accounting

$69K - $125K *

Lead the charge in crafting high-quality proposals and managing complex RFP processes while ensuring alignment with customer specifications and company standards under tight deadlines...

United StatesRemote

Reposted 1 month ago

  •   Less than 5 years exp.  •   Healthcare

$128K - $170K *

Optimize financial strategies and drive growth initiatives as a trusted advisor to leadership. Engage in M&A analysis, pricing strategy, and market insights to enhance decision-making in a dynamic Saa...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead feasibility strategy and execution for clinical studies, driving operational excellence and data-driven insights to optimize trial planning and enrollment across rare disease programs. Collaborat...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$104K - $143K *

Unlock your potential by leading strategic initiatives that drive measurable business results. Collaborate with senior leaders to solve complex problems, evaluate opportunities, and translate strategy...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$206K - $413K *

Join our team to lead in Physical Medicine and Rehabilitation, providing oversight, improving utilization, and guiding medical policy. Collaborate with staff and external partners to enhance healthcar...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$136K - $205K *

Drive the implementation of innovative CXA and CCaaS solutions for healthcare and life sciences clients, ensuring strategic alignment and excellence in project delivery while mentoring teams and enhan...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Join a dynamic team to support product management for government insurance, ensuring compliance and driving strategic initiatives. Leverage your expertise to lead analysis, define requirements, and en...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Deliver innovative solutions by managing complex programs, ensuring seamless execution and coordination across multiple contracts while leveraging extensive IT expertise and leadership skills to drive...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$144K - $194K *

Accelerate progress at the forefront of oncology marketing by leading global initiatives, synthesizing insights, and driving execution across teams to enhance product strategies and launch readiness...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$159K - $218K *

Drive strategic growth by leading national accounts and fostering executive relationships. Collaborate across teams to enhance customer engagement and market share, while executing comprehensive accou...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$170K - $205K *

Champion the growth of a new kidney transplant product by driving U.S. sales strategy, building key relationships, and executing strategic account plans to exceed revenue targets while collaborating c...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$113K - $226K *

Lead the charge in optimizing healthcare processes by bridging strategy and execution. Collaborate with teams to enhance coding workflows, drive change management, and ensure alignment with strategic...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $140K *

Elevate your career by joining a dynamic sales team driving colorectal cancer screening solutions. Engage healthcare professionals, provide education, and strategize business growth across a vibrant t...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$165K - $215K *

Shape the future of value-based payments by leading product strategy, overseeing team development, and driving market innovations within a collaborative, cross-functional environment...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$210K - $250K *

Empower a dynamic team of reimbursement professionals to enhance provider access and education. Drive strategic initiatives, foster collaboration, and ensure compliance while navigating complex payer...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$94K - $130K *

Elevate product outcomes by collaborating with teams to prioritize and define user stories, ensuring alignment with business needs while maximizing value delivery and maintaining product quality throu...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Take ownership of financial and operational analysis for strategic initiatives, delivering critical insights and reporting to support executive decision-making while driving accuracy and efficiency in...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Elevate healthcare through strategic AI product management, driving innovation and lifecycle management of AI solutions. Collaborate cross-functionally to align business objectives with customer needs...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$350K - $398K *

Drive impactful clinical trials in ophthalmology with leadership in study design, execution, and biomarker strategy. Collaborate cross-functionally to ensure timely delivery and regulatory compliance...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$72K - $192K *

Join a team that's dedicated to enhancing client relationships in healthcare. As a trusted advisor, you'll guide clients through workflows, drive feature adoption, and develop strategic plans to maxim...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$119K - $134K *

Partner with us to enhance patient care by supporting primary care teams remotely. Collaborate with on-site providers to manage patient needs effectively, ensuring seamless communication and coordinat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $150K *

Champion continuous improvement initiatives by optimizing processes and products across the organization. Lead cross-functional teams to enhance operational efficiency, quality, and customer experienc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$104K - $143K *

Empower healthcare transformation by developing strategic initiatives that enhance operational efficiency and clinician productivity. Collaborate cross-functionally to drive impactful solutions and im...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Unlock potential by managing pharmacy operations, supervising staff, and ensuring compliance. Cultivate leadership crucial for team growth and efficient workflow while delivering exceptional patient c...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.