Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Oncologist Jobs in South Dakota

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$197K - $260K *

Transform customer experiences by leading technical discovery and designing innovative data solutions. Collaborate with sales and engineering teams to drive adoption and expansion of the dbt platform...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$111K *

Unlock potential by leading Clinical Documentation Integrity operations, enhancing physician engagement, and driving performance improvement. Collaborate with diverse teams to ensure compliance and op...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $150K *

Engage as a key Contract Manager, overseeing procurement agreements and providing strategic guidance across teams. Collaborate on complex projects, ensuring compliance and effective negotiation while...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Empower decision-making by utilizing data-driven insights to enhance operations, supporting growth through statistical modeling and AI techniques while maintaining compliance in a complex regulatory e...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Unlock potential by leading sales strategies that drive revenue growth, collaborating with experts to execute impactful cycles, and consistently achieving quotas in a dynamic market focused on health...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $170K *

Join us to bridge technology and clients in the mortgage industry. You'll engage directly with customers, develop solutions, and influence product direction while driving efficiency and innovation in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$75K - $90K *

Drive innovative advertising strategies by transforming customer insights and performance data into compelling creative content. Collaborate with cross-functional teams to enhance product visibility a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$125K - $150K *

Bring your expertise to drive revenue growth in healthcare through consultative sales and strategic partnerships. Own the full sales cycle, collaborate cross-functionally, and mentor future hires in a...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $150K *

Champion social strategy and community engagement, driving impactful growth across multiple channels. Lead a dynamic team to create culturally relevant content, leveraging AI for efficiency and innova...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in building strategic partnerships that drive revenue and growth. Collaborate across teams to identify opportunities, negotiate agreements, and create impactful integrations that enhan...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Unlock potential by leading pre-sales technical strategies that align solutions with client needs, driving revenue growth and retention through collaboration with sales teams and delivering tailored p...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Champion strategic growth by managing major law enforcement accounts, driving revenue, and fostering relationships with key stakeholders. Collaborate cross-functionally to ensure successful outcomes a...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$156K - $214K *

Transform the digital landscape for Medical Affairs by owning product vision, prioritizing backlogs, and ensuring compliance. Collaborate with experts to deliver insights and enhance engagement throug...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$245K - $265K *

Build impactful partnerships with Medical Experts to enhance neurology care. Drive strategic insights and collaboration across teams, influencing marketing and education initiatives while engaging wit...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join a team that's shaping global regulatory strategy for rare disease therapies. In this pivotal role, you'll lead submissions and agency interactions across the US, EU, UK, and Japan, driving execut...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Staffing

$100K - $160K *

Join a team that's transforming healthcare with AI solutions. As an AI Solutions Engineer, you'll develop integrations and tools that enhance customer workflows, bridging the gap between clients and o...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$66K - $99K *

Champion patient care by utilizing your nursing expertise to lead clinical teams, coordinate care, and mentor staff. Engage in effective communication and critical thinking to enhance patient outcomes...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Drive transformative AI initiatives across departments by leading a strategic team in designing scalable, agentic workflows that enhance decision-making and efficiency, ensuring measurable business ou...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Transform clinical operations by leading a dynamic team, ensuring high-quality trial management, and driving innovation through technology and AI solutions. Your strategic oversight will enhance perfo...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $150K *

Shape the future of safety in a dynamic environment by developing and enhancing EHS programs. Collaborate across teams to foster a culture of safety and compliance, ensuring adherence to regulations w...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$105K - $129K *

Drive impactful market analysis and reporting as a Senior Analyst, leveraging data to guide strategic investments and growth opportunities. Collaborate with teams to enhance decision-making and optimi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$184K - $253K *

Drive global pharmacovigilance efforts by managing safety data, leading clinical development strategies, and collaborating across teams to enhance product safety and efficacy throughout their lifecycl...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$145K - $170K *

Design innovative AI solutions on Microsoft Azure, bridging business needs and engineering execution. Own the architecture, ensure security, and lead the build process while adapting to evolving proje...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$118K - $196K *

Lead the charge in developing and executing drug formulary strategies, ensuring compliance with regulations while collaborating with cross-functional teams to enhance pharmacy utilization management a...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Join a team that's leading Medicaid programs and initiatives, driving operational excellence and policy implementation while managing multidisciplinary teams and enhancing organizational performance a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.