Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Solutions Architect, Enterprise
$197K - $260K *
Transform customer experiences by leading technical discovery and designing innovative data solutions. Collaborate with sales and engineering teams to drive adoption and expansion of the dbt platform...
3 weeks ago
Clinical Documentation Manager
$111K *
Unlock potential by leading Clinical Documentation Integrity operations, enhancing physician engagement, and driving performance improvement. Collaborate with diverse teams to ensure compliance and op...
3 weeks ago
$110K - $150K *
Engage as a key Contract Manager, overseeing procurement agreements and providing strategic guidance across teams. Collaborate on complex projects, ensuring compliance and effective negotiation while...
3 days ago
$110K - $130K *
Empower decision-making by utilizing data-driven insights to enhance operations, supporting growth through statistical modeling and AI techniques while maintaining compliance in a complex regulatory e...
Reposted 1 week ago
Director, Business Development - RCM Sales
$125K - $150K *
Unlock potential by leading sales strategies that drive revenue growth, collaborating with experts to execute impactful cycles, and consistently achieving quotas in a dynamic market focused on health...
1 month ago
Mortgage Forward Deployed Engineer
$150K - $170K *
Join us to bridge technology and clients in the mortgage industry. You'll engage directly with customers, develop solutions, and influence product direction while driving efficiency and innovation in...
1 week ago
$75K - $90K *
Drive innovative advertising strategies by transforming customer insights and performance data into compelling creative content. Collaborate with cross-functional teams to enhance product visibility a...
1 week ago
Senior Business Development Manager, Health Systems and PACE
$125K - $150K *
Bring your expertise to drive revenue growth in healthcare through consultative sales and strategic partnerships. Own the full sales cycle, collaborate cross-functionally, and mentor future hires in a...
4 days ago
$120K - $150K *
Champion social strategy and community engagement, driving impactful growth across multiple channels. Lead a dynamic team to create culturally relevant content, leveraging AI for efficiency and innova...
2 weeks ago
Principal, Strategic Alliances & Partnerships
$150K - $180K *
Lead the charge in building strategic partnerships that drive revenue and growth. Collaborate across teams to identify opportunities, negotiate agreements, and create impactful integrations that enhan...
2 weeks ago
$120K - $145K *
Unlock potential by leading pre-sales technical strategies that align solutions with client needs, driving revenue growth and retention through collaboration with sales teams and delivering tailored p...
Today
$80K - $95K *
Champion strategic growth by managing major law enforcement accounts, driving revenue, and fostering relationships with key stakeholders. Collaborate cross-functionally to ensure successful outcomes a...
1 week ago
Digital Technology Product Owner, Medical Affairs
$156K - $214K *
Transform the digital landscape for Medical Affairs by owning product vision, prioritizing backlogs, and ensuring compliance. Collaborate with experts to deliver insights and enhance engagement throug...
4 weeks ago
Director, Neurology - Thought Leader Liaison (NORTHEAST)
$245K - $265K *
Build impactful partnerships with Medical Experts to enhance neurology care. Drive strategic insights and collaboration across teams, influencing marketing and education initiatives while engaging wit...
2 weeks ago
$150K - $180K *
Join a team that's shaping global regulatory strategy for rare disease therapies. In this pivotal role, you'll lead submissions and agency interactions across the US, EU, UK, and Japan, driving execut...
4 weeks ago
$100K - $160K *
Join a team that's transforming healthcare with AI solutions. As an AI Solutions Engineer, you'll develop integrations and tools that enhance customer workflows, bridging the gap between clients and o...
3 weeks ago
$66K - $99K *
Champion patient care by utilizing your nursing expertise to lead clinical teams, coordinate care, and mentor staff. Engage in effective communication and critical thinking to enhance patient outcomes...
1 week ago
Director, Enterprise Enablement
$150K - $180K *
Drive transformative AI initiatives across departments by leading a strategic team in designing scalable, agentic workflows that enhance decision-making and efficiency, ensuring measurable business ou...
Reposted 3 days ago
Senior Clinical Operations Manager, Canada/USA, remote
$110K - $130K *
Transform clinical operations by leading a dynamic team, ensuring high-quality trial management, and driving innovation through technology and AI solutions. Your strategic oversight will enhance perfo...
2 weeks ago
EHS Specialist- Environment, Health & Safety
$80K - $150K *
Shape the future of safety in a dynamic environment by developing and enhancing EHS programs. Collaborate across teams to foster a culture of safety and compliance, ensuring adherence to regulations w...
3 days ago
Senior Analyst, Decision Science (Market Analyst)
$105K - $129K *
Drive impactful market analysis and reporting as a Senior Analyst, leveraging data to guide strategic investments and growth opportunities. Collaborate with teams to enhance decision-making and optimi...
1 week ago
Associate Medical Director, Global Safety Physician
$184K - $253K *
Drive global pharmacovigilance efforts by managing safety data, leading clinical development strategies, and collaborating across teams to enhance product safety and efficacy throughout their lifecycl...
Today
Solution Architect, Forward Deployed Architecture (AI Capability Center)
$145K - $170K *
Design innovative AI solutions on Microsoft Azure, bridging business needs and engineering execution. Own the architecture, ensure security, and lead the build process while adapting to evolving proje...
2 weeks ago
Senior Pharmacist - Strategy (Hybrid)
$118K - $196K *
Lead the charge in developing and executing drug formulary strategies, ensuring compliance with regulations while collaborating with cross-functional teams to enhance pharmacy utilization management a...
3 weeks ago
$110K - $130K *
Join a team that's leading Medicaid programs and initiatives, driving operational excellence and policy implementation while managing multidisciplinary teams and enhancing organizational performance a...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.