Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$250K - $300K *
Champion innovative neurological care by providing expert medical services to patients. Collaborate with a dedicated team to enhance patient outcomes and advance your practice in a supportive environm...
Reposted 2 days ago
Clinical Applications Specialist, Invasive Cardiology - Houston, TX
$90K - $110K *
Champion clinical education and training by delivering expert knowledge and support to enhance user competencies and optimize patient care within a defined territory. Build strong relationships with s...
6 days ago
$153K - $210K *
Transform your career by partnering with teams to drive strategic growth through legal expertise in healthcare contracts, negotiations, and compliance. Collaborate with leadership to optimize performa...
3 weeks ago
$73K - $88K *
Accelerate progress at expanding customer accounts by driving annual recurring revenue and enhancing retention through structured sales strategies and digital engagement, while managing a high-volume...
1 week ago
Operations Director, Biomarker Programs
$175K - $200K *
Lead the charge in optimizing biomarker program operations, ensuring seamless sample processing from collection to storage. Collaborate across teams to uphold quality and compliance while driving grow...
2 weeks ago
Project Manager II, dermatology and rheumatology CRO,USA
$95K - $115K *
Champion project success by leading clinical trials from initiation to closure, ensuring compliance with budgets, timelines, and regulations while fostering collaboration among stakeholders and team m...
Yesterday
$96K - $144K *
Lead the charge in delivering exceptional customer service and technical support at assigned medical equipment sites, ensuring compliance with contracts and fostering strong client relationships throu...
2 weeks ago
Physician, Family Medicine - Telemedicine Opportunity - DrHouse
$210K *
Elevate patient care by delivering high-quality telehealth services across South Dakota. Join a compassionate team of board-certified physicians managing diverse clinical cases through innovative virt...
3 days ago
Pre-sales Solutions Consultant, Clinical
$90K - $110K *
Engage with clients to showcase innovative healthcare solutions, driving sales success through impactful demonstrations and expert guidance. Collaborate with sales teams to address client needs and en...
3 weeks ago
$105K - $120K *
Drive impactful research initiatives by leading complex projects, mentoring teams, and securing new business opportunities. Collaborate with diverse stakeholders to deliver high-quality evaluations an...
6 days ago
Director, Advanced Analytics and Data Science - Innovation
$174K - $234K *
Shape the future of advanced analytics and AI, driving data-driven solutions across commercial, medical, and clinical operations. Collaborate cross-functionally to deliver insights, enhance decision-m...
Reposted 3 weeks ago
$165K - $194K *
Pioneer impactful scientific exchanges as a Senior Medical Science Liaison, fostering relationships with healthcare providers and key opinion leaders in hematology/oncology while supporting Rigel's in...
1 week ago
$95K - $115K *
Unlock potential by shaping innovative solutions for Opioid Treatment Programs and Medication Assisted Treatment. Collaborate with clients and teams to translate complex needs into actionable product...
4 weeks ago
Account Executive, Enterprise Suite - Financial Services
$124K - $171K *
Accelerate sales growth by managing and qualifying strategic Enterprise Intelligence opportunities. Collaborate with cross-functional teams, ensuring comprehensive engagement and communication to opti...
Reposted 3 days ago
$201K - $251K *
Transform workforce intelligence by leading People Analytics, establishing data governance, and driving strategic decision-making in a high-growth environment. Collaborate across functions to enhance...
3 weeks ago
Clinical Trial Manager II, Dermatology & Rheumatology CRO, USA
$100K - $120K *
Engage with a dynamic CRO to oversee clinical monitoring and enhance site performance. Foster relationships, ensure compliance with regulations, and lead a team in delivering quality outcomes in clini...
Reposted 3 weeks ago
Partner Manager, AI Ecosystems
$140K - $175K *
Empower Apollo's frontier partnerships by deepening collaborations with AI-native platforms and foundation model companies. Analyze the evolving landscape and drive monetization strategies while build...
Reposted 2 weeks ago
Clinical Documentation Manager
$73K - $115K *
Unlock the potential of clinical documentation integrity by driving ICD-10-CM coding accuracy and enhancing provider education. Collaborate with cross-functional teams to support risk adjustment initi...
1 week ago
Director, Sales Strategy & Value
$150K - $180K *
Unlock potential by driving sales strategy and value analysis, partnering with cross-functional teams to enhance proposals, pricing, and contracts. Lead market research and client engagement to optimi...
2 weeks ago
Clinical Application Specialist, Monitoring
$90K *
Elevate your career by providing clinical support and training for patient monitoring systems. Lead implementation teams, ensure customer satisfaction, and maintain clinical expertise while managing t...
Reposted yesterday
Senior Denials Prevention Process Improvement Advisor
$68K - $103K *
Shape the future of revenue cycle management by driving process improvements and reducing denials. Collaborate with teams to analyze trends, implement best practices, and enhance client satisfaction t...
1 week ago
$225K - $250K *
Transform operations by leading a diverse team to enhance profitability and efficiency across multiple sites, while building strategic relationships with clients and driving growth initiatives in the...
1 week ago
Senior Manager - APR DRG Concept Development Analyst
$100K - $125K *
Transform healthcare analytics by leading the development of APR-DRG audit criteria. Collaborate with cross-functional teams to enhance payment integrity through data-driven insights and innovative so...
1 week ago
Senior Director, Business Development
$194K - $266K *
Lead the charge in driving commercial growth by securing high-value partnerships and expanding market presence. Mentor a dynamic team while executing strategic initiatives that enhance client relation...
1 week ago
$180K - $220K *
Lead the sales strategy for a healthcare Payer business unit, driving market penetration, revenue growth, and client satisfaction. Collaborate with leadership to shape go-to-market strategies and buil...
Today
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.