Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$80K - $95K *
Champion excellence in rehabilitation services by leading a dedicated team, ensuring compliance with regulations, and enhancing patient care while achieving financial goals and fostering collaboration...
2 weeks ago
Senior Construction Specialist
$71K - $113K *
Join a team that's dedicated to managing specialty construction portfolios, ensuring compliance with lending policies, and guiding borrowers through the construction loan process while mitigating risk...
2 weeks ago
Cardiovascular Account Specialist - U.S. Sales, Des Moines, IA
$162K - $195K *
Lead the launch of a novel cardiac myosin inhibitor in your territory, driving sales and building strategic relationships with healthcare providers. Collaborate with internal teams to meet patient nee...
Yesterday
$132K - $153K *
Join a team that's redefining care management by leading strategic initiatives in utilization and appeals processes. Drive high-quality, cost-effective care while ensuring compliance and fostering a c...
6 days ago
$174K - $374K *
Unlock potential by leading medical management initiatives remotely, supporting member needs and optimizing clinical services for optimal care. Leverage your expertise in Orthopedic Spine or Neurosurg...
Reposted 1 week ago
$100K - $130K *
Transform healthcare by leading a dynamic PMO, ensuring program transparency and compliance across multiple customer accounts while fostering collaboration and continuous improvement...
Yesterday
$227K - $385K *
Elevate member care by overseeing utilization management and evaluating treatment appropriateness. Collaborate with multidisciplinary teams, ensuring compliance with clinical standards and regulations...
Reposted 1 week ago
$150K - $180K *
Pioneer innovative strategies as a Medical Science Liaison, engaging with key opinion leaders and driving platform adoption. Collaborate across teams to translate clinical needs into actionable insigh...
2 weeks ago
Senior Director, DMPK Project Leader
$177K - $338K *
Champion DMPK project leadership by ensuring high-quality data delivery and supporting drug candidate progression through innovative modeling and cross-functional collaboration in a dynamic biotech en...
Reposted 3 days ago
National Account Director, Enterprise Access
$240K - $269K *
Advance your career by leading national account strategies in oncology, fostering relationships with health plans and PBMs. Drive coverage, reimbursement, and adoption initiatives while collaborating...
1 week ago
$125K - $145K *
Lead campaign strategy and execution for oncology pharma marketing, driving performance optimization and cross-functional collaboration. Own end-to-end campaign management, ensuring alignment with bus...
Reposted 3 days ago
$66K - $102K *
Join a dedicated team to operate mammography equipment, ensuring quality imaging and patient care. Contribute to women's health by performing examinations, educating clients, and maintaining safety st...
2 weeks ago
Director, NDD Business Development: Health Systems
$162K - $224K *
Elevate healthcare solutions by driving business development in neurodegenerative disease pathways. Collaborate with health systems and stakeholders to identify needs, develop strategies, and create i...
1 week ago
$72K - $120K *
Transform healthcare systems by analyzing data, leading client engagements, and implementing performance improvements. Collaborate with a skilled team to deliver actionable insights and drive meaningf...
Today
Vice President, Value Partnerships DX
$207K - $284K *
Elevate strategic partnerships in the healthcare diagnostics sector, driving innovative solutions and collaboration across teams. Lead high-impact initiatives that align customer needs with Siemens He...
2 weeks ago
Account Specialist (Toledo, OH)
$160K - $192K *
Transform healthcare engagement by driving commercial performance and building strong relationships with providers. Collaborate cross-functionally to support product launches and ensure patient access...
6 days ago
Principal Architect, Healthcare
$165K - $243K *
Deliver innovative disaster recovery solutions for healthcare systems, ensuring compliance and resilience for clinical workloads. Collaborate with cross-functional teams to address complex challenges...
1 week ago
Sr. Associate Actuary - Healthcare
$120K - $140K *
Elevate healthcare consulting by leading complex actuarial projects, developing financial models, and advising clients on policy impacts. Collaborate with teams to analyze data, mentor analysts, and e...
1 week ago
$150K - $180K *
Join a dynamic team to lead and scale clinical operations, overseeing performance and process optimization. Build accountable teams, manage metrics, and partner with stakeholders to enhance operationa...
Reposted 4 weeks ago
$100K - $120K *
Partner with us to drive revenue growth and strategic account management across a diverse portfolio. You'll own the full sales cycle, collaborate with cross-functional teams, and build lasting relatio...
3 weeks ago
$100K - $120K *
Transform patient safety operations by leading a dedicated team, ensuring compliance, and enhancing pharmacovigilance processes. Collaborate cross-functionally to deliver high-quality safety services...
Today
$175K - $215K *
Launch impactful product initiatives by bridging engineering and design while driving user-centered solutions and leveraging AI tools for enhanced workflows in a high-growth environment...
Reposted 3 weeks ago
Senior Director, Innovation and Delivery
$200K - $250K *
Drive critical initiatives by navigating ambiguity, building effective operating models, and ensuring measurable outcomes in a dynamic environment. Engage with leadership to implement AI solutions and...
Reposted 4 weeks ago
$195K - $244K *
Unlock your potential as a Global Regulatory Leader, driving regulatory strategy and submissions for CNS projects. Collaborate with cross-functional teams, mentor junior staff, and ensure compliance w...
3 weeks ago
Clinical Trial Manager/Sr Clinical Trial Manager
$145K - $190K *
Join a team dedicated to advancing oncology clinical trials. In this role, you’ll manage global studies, oversee vendors, collaborate with multi-disciplinary teams, and ensure compliance with regulato...
Reposted 1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.