Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Optometrist - Doctor of Optometry (Employee)
$200K *
Join a team that's dedicated to delivering exceptional eye care solutions while thriving in a dynamic, patient-centered environment. Utilize innovative technology to conduct comprehensive exams and cr...
1 week ago
In-Home Health - Nurse Practitioner or Physician Assistant (Full Time) - Onondaga, NY
$95K - $206K *
Advance health outcomes by providing in-home evaluations, fostering trust and personalized care. Engage with patients to bridge gaps in health services, ensuring comprehensive support tailored to indi...
5 days ago
Director, Medical Science Liaison (Dallas, AR, LA, OK, MS)
$236K - $259K *
Join a team that advances medical knowledge and relationships in lung cancer. As a key liaison, engage with healthcare professionals, support scientific initiatives, and collaborate cross-functionally...
Reposted 4 weeks ago
Head of Emerging & Digital Therapeutics
$190K - $236K *
Develop and implement innovative therapeutic approaches to enhance mental health outcomes. Collaborate across departments to evaluate, integrate, and govern emerging treatments, ensuring clinical feas...
3 weeks ago
Regional Account Executive - Ohio (South)
$80K - $95K *
Drive growth by managing strategic accounts, developing new business, and nurturing relationships within your territory. Collaborate with teams to ensure client satisfaction and achieve sales targets...
2 days ago
$110K - $130K *
Innovate data-driven product strategies by leading informatics initiatives, ensuring rigorous testing and quality assessments while collaborating across teams to enhance client services and streamline...
Today
Clinical Application Support Specialist II- RO
$70K - $105K *
Unlock potential by providing exceptional support and training in clinical software, ensuring customer satisfaction through effective communication and problem-solving in a fast-paced environment. Joi...
2 weeks ago
VP, Labor & Public Sector Sales
$215K - $250K *
Pioneer your career by leading a dynamic sales team focused on Labor and Public Sector markets. Drive growth, mentor talent, and execute strategic initiatives to exceed revenue goals while building im...
2 weeks ago
Clinical Solutions Specialist, Ambulatory Surgery Centers (ASC)- Southeast
$76K - $114K *
Unlock potential by driving growth in Electrophysiology-focused Ambulatory Surgery Centers. Leverage clinical expertise to build relationships, enhance product adoption, and ensure customer satisfacti...
2 weeks ago
Senior Applications Analyst - Billing
$123K - $207K *
Elevate enterprise systems by leading design and enhancements, ensuring reliability and usability. Collaborate with cross-functional teams to translate requirements into scalable solutions while drivi...
Yesterday
Strategy and Operations Physician Enterprise Clinical SME
$125K - $235K *
Drive operational excellence in healthcare by leading transformative initiatives, optimizing workflows, and enhancing provider productivity. Collaborate with teams to deliver data-driven solutions tha...
6 days ago
Client Success Manager, Payer Retrieval
$108K - $130K *
Unlock your potential by leading customer projects, ensuring seamless communication, and driving success in healthcare solutions. Collaborate with diverse teams to enhance client satisfaction and oper...
1 week ago
Clinical Solutions Specialist, Ambulatory Surgery Centers (ASC)- South Central
$76K - $114K *
Elevate the clinical sales landscape by driving growth in Electrophysiology-focused Ambulatory Surgery Centers. Leverage your clinical expertise to build relationships, enhance product adoption, and e...
2 weeks ago
Complex Claims Advisor | Dedicated Client | East Coast States
$90K - $100K *
Unlock potential by managing complex claims with a focus on legal inquiries and resolutions. Collaborate with clients and experts to deliver innovative solutions while enjoying flexibility and profess...
1 week ago
Senior Case Manager RN - Transplant RN (Remote)
$79K - $127K *
Optimize member health outcomes by managing complex care plans, coordinating services, and advocating for quality, cost-effective healthcare. Collaborate with healthcare teams to assess needs and moni...
Reposted 1 week ago
GTM Senior Solutions Consultant (Presales)
$185K - $205K *
Shape the future of customer success by leading complex SaaS solutions, driving strategic partnerships, and mentoring teams to enhance value delivery and accelerate growth across enterprise accounts...
2 weeks ago
Applications Analyst- Epic Professional Billing
$67K - $111K *
Elevate your career by providing critical analysis and programming support for application software, ensuring a comprehensive and integrated information network that meets diverse customer needs and e...
2 days ago
$70K - $106K *
Champion patient care by coordinating and delivering occupational therapy services to improve health outcomes, engaging with interdisciplinary teams to develop tailored treatment programs for diverse...
Reposted 2 weeks ago
Principal Sales Solutions Consultant
$160K - $195K *
Engage with healthcare payer clients to architect integrated solutions, driving revenue growth through strategic discovery, technical leadership, and value engineering. Collaborate across teams to del...
4 days ago
$190K - $230K *
Join a team that's driving innovation in biopharma partnerships. Leverage your expertise to identify and advance strategic opportunities, influence cross-functional decisions, and manage alliances tha...
6 days ago
$141K - $196K *
Unlock potential by developing causal machine-learning models to optimize customer offers, analyzing complex data, and translating findings into actionable strategies for enhanced conversion rates acr...
Today
Director, Global Regulatory Affairs - Cardiometabolic Disorders
$195K - $264K *
Drive global regulatory strategies for obesity and cardiometabolic disorders, ensuring alignment across teams and leading interactions with health authorities. Leverage scientific expertise to navigat...
Today
Senior Health Systems Specialist - Data & Analytics
$110K - $130K *
Advance analytics and informatics solutions by integrating VA databases, developing dashboards, and collaborating in Agile teams to enhance healthcare delivery for Veterans, ensuring effective data ma...
4 weeks ago
$175K *
Optimize revenue cycle management by leading a dynamic team to enhance processes, drive automation, and ensure compliance in a fast-paced telehealth environment. Collaborate with cross-functional team...
1 week ago
$141K - $234K *
Transform healthcare analytics by leveraging advanced statistics and machine learning to uncover insights from complex datasets. Collaborate with experts to innovate and develop data-driven solutions...
Reposted 3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.