Explore North Carolina Jobs Paying $100K or More

Discover professional opportunities across North Carolina with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking their next career move, from senior individual-contributor positions to executive leadership. Explore openings in major employment centers such as Charlotte, Raleigh, Durham, and Greensboro, as well as opportunities across the state.

Find Opportunities Across North Carolina

North Carolina offers a diverse job market shaped by financial services, technology, healthcare, life sciences, manufacturing, and professional services. Charlotte is a major hub for banking and corporate leadership, while the Raleigh-Durham region is known for technology, research, healthcare, and life sciences. Opportunities may also be available in Greensboro, Winston-Salem, Asheville, and other communities.

Explore Senior Roles Across Industries

Search for experienced-level roles in areas such as technology, finance, operations, sales, marketing, healthcare, engineering, and general management. Job titles, qualifications, work arrangements, and compensation vary by employer. Review each listing for details and identify opportunities that match your background and career goals.

Advance Your Career With Ladders

Ladders focuses on vetted professional jobs paying $100,000 or more, helping experienced candidates explore opportunities aligned with their expertise. Use this page to browse North Carolina openings, compare roles, and discover your next step. Listings and availability change, so check back regularly for new opportunities.

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1,000+

Jobs in North Carolina

Average Salary in USD

Average Salary: $115,032

Sort By: Relevance

$180K - $220K *

Manage strategic partnerships with C-suite executives in healthcare, driving enterprise adoption of precision medicine solutions. Collaborate across teams to implement and scale initiatives, ensuring...

North Carolina, USRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $168K *

Pioneer application modernization efforts by leading agile teams, driving technical outcomes, and enhancing developer experiences. Collaborate with clients to deliver measurable business results while...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a team that's redefining mechanical contracting by leading a dynamic branch. Oversee construction and service operations, manage P&L, and drive business growth while guiding a talented team of ov...

3 days ago

  •   8 - 10 years exp.  •   Staffing

$160K - $200K *

Drive growth by leading strategic partnerships in healthcare tech. Collaborate with executives to shape joint strategies, negotiate impactful deals, and operationalize go-to-market initiatives that en...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$190K - $249K *

Join a team that's bridging technical solutions with client needs, driving digital transformation. Leverage your expertise to build relationships, influence decisions, and ensure customer success thro...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Transform demand generation strategies in the Consumer & Life Sciences sectors. Lead initiatives to create impactful marketing campaigns, enhance customer engagement, and collaborate with cross-functi...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$77K - $144K *

Oversee the onboarding program and training processes, ensuring compliance and efficiency. Collaborate with stakeholders to enhance LMS functionality and support continuous improvement initiatives whi...

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Champion patient recovery by delivering individualized, evidence-based physical therapy. Collaborate with a dedicated team to enhance mobility and improve lives, while fostering professional growth an...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$98K - $115K *

Join a team that's dedicated to delivering innovative payment solutions while leading audit engagements. As an Audit Project Manager, you'll supervise staff, ensure quality work, and collaborate acros...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$142K - $202K *

Unlock commercial potential by executing transformation workstreams, collaborating with cross-functional teams, and delivering strategic insights to drive measurable results in a healthcare-focused en...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Elevate AI experiences from concept to value by collaborating with engineering and design teams. Drive strategy, build prototypes, and make data-driven decisions to enhance user engagement and product...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Help us shape the future of federal security architecture by developing integrated designs and compliance strategies that protect sensitive information while ensuring reliable business operations acro...

3 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$160K - $200K *

Transform client relationships by driving business growth, securing profitable projects, and leveraging market access expertise. Lead teams to exceed expectations while identifying industry trends and...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$165K - $220K *

Join a team that's redefining avionics systems engineering by translating customer needs into innovative architectures and requirements. Collaborate across domains to deliver high-quality solutions in...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$66K - $105K *

Join a team that's dedicated to delivering exceptional patient care through comprehensive assessments, individualized care plans, and effective collaboration with healthcare professionals to enhance p...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Drive your career with a strategic sales leadership role focused on enterprise growth in healthcare. Lead complex business development efforts, build executive relationships, and shape solutions that...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $155K *

Lead the AI/ML product strategy across multiple business units, driving integration and data-centric solutions that enhance customer value and revenue growth through innovative workflows and collabora...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Lead the charge in civil engineering for transmission and substation projects. Oversee site work, ensure compliance, and mentor engineers while collaborating with multidisciplinary teams to deliver hi...

3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$108K - $130K *

Elevate your career by leading civil site projects for transmission and substations. Drive engineering excellence, manage site compliance, and collaborate with multidisciplinary teams to deliver innov...

Charlotte, NCRemote

3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$106K - $146K *

Shape the future of our operations by leading a dynamic team to optimize Quote-to-Cash strategies, enhance analytics, and design streamlined workflows, all while collaborating across functions to driv...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$280K - $350K *

Unlock potential by leading a high-performing Enterprise sales team to drive revenue growth, mentor talent, and align strategies across departments, ensuring success in complex B2B SaaS solutions for...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Lead the charge in driving customer success for mid-market accounts, ensuring adoption and renewals while identifying growth opportunities. Collaborate cross-functionally to enhance customer experienc...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$68K - $115K *

Grow client relationships and drive sales in a remote field role, focusing on the Mid-Atlantic market. Engage with clients to understand their needs, resolve concerns, and expand market awareness whil...

3 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$110K - $130K *

Champion the evolution of organic search strategies across enterprise software brands. Lead initiatives in technical SEO, content optimization, and AI-driven search, driving visibility and revenue whi...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100K-plus jobs can I find in North Carolina?question toggle

    Listings may include senior and executive opportunities across technology, finance, healthcare, life sciences, manufacturing, sales, operations, engineering, and other professional fields. Availability and requirements vary by employer.

  • Which North Carolina cities have high-paying job opportunities?question toggle

    Opportunities may be found in Charlotte, Raleigh, Durham, Greensboro, Winston-Salem, Asheville, and other parts of the state. The location of each position is shown in its listing.

  • Are North Carolina jobs on Ladders vetted?question toggle

    Ladders focuses on vetted professional jobs that pay $100,000 or more. Review each job listing for the employer, qualifications, compensation information, and application details.

  • Can I find remote or hybrid jobs based in North Carolina?question toggle

    Some employers offer remote or hybrid arrangements, but work options differ by role. Check the individual listing for its location and workplace requirements.

  • How often should I check for new North Carolina jobs?question toggle

    Listings change as employers add or fill positions. Check back regularly to see newly available opportunities that match your experience and salary goals.