Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $115K *

Drive manufacturing excellence by ensuring production equipment operates safely and efficiently. Manage diverse projects, provide technical expertise, and develop process improvements while collaborat...

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Transform the landscape of operational resilience by leading architectural strategies that enhance technology investments, ensuring robust recoverability and continuity across infrastructures, cloud...

Reposted yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $170K *

Manage complex design and construction projects across the U.S., ensuring alignment with budget, schedule, and quality standards. Collaborate with stakeholders to drive effective design processes and...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Technical Services

$110K - $130K *

Champion the governance of AI risks by executing the Enterprise Risk Management framework. Collaborate with teams to assess, mitigate, and monitor risks associated with AI technologies, ensuring compl...

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $186K *

Transform procurement strategies by leading vendor management and building strategic partnerships. Drive operational efficiency while optimizing spend and enhancing supplier performance to support lon...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Technical Services

$95K - $115K *

Drive the design and administration of complex network environments, collaborating across teams to implement standardized solutions using Cisco technologies. Ensure seamless deployment and support whi...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$135K - $165K *

Unlock potential by leading growth marketing initiatives. Drive conversion from click to customer through strategic ad management, structured testing, and insightful analysis. Collaborate closely with...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$105K - $133K *

Drive the development of innovative enterprise applications across cloud platforms. Collaborate with cross-functional teams to design, implement, and optimize solutions using modern technologies, ensu...

Yesterday

  •   5 - 7 years exp.  •   Business Services

$75K - $90K *

Join a team that's dedicated to organic growth as you lead SEO strategies and initiatives. Collaborate with cross-functional teams, drive measurable performance, and optimize client accounts in divers...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$192K - $278K *

Lead and grow a high-performing engineering team responsible for the reliability and scalability of critical data systems. Drive architectural decisions, incident response, and team development while...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$155K - $175K *

Lead the development of robust security capabilities for a cutting-edge platform, ensuring secure identity and access management across diverse environments. Collaborate with cross-functional teams to...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$80K - $95K *

Join a team that's dedicated to enhancing user training and support for Epic applications. Collaborate with analysts to develop effective training materials and ensure seamless implementation, while m...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$88K - $105K *

Drive project management excellence by overseeing engineering solutions that exceed client expectations, ensuring timely delivery and budget adherence while collaborating with diverse teams and stakeh...

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $145K *

Drive innovation in Pega implementations, guiding teams in delivering advanced BPM solutions. Utilize strong design skills and deep application knowledge to create high-quality user experiences while...

Reposted yesterday

  •   8 - 10 years exp.  •   Information Technology

$105K - $133K *

Unlock potential by providing advanced payment support and data analytics expertise. Collaborate across teams to resolve payment issues, enhance data quality, and drive operational efficiency in a dyn...

Yesterday

  •   5 - 7 years exp.  •   Business Services

$160K - $200K *

Transform the global Professional Services strategy, leading a high-performing team to enhance customer outcomes and drive commercial success through innovative implementation and consulting services...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$215K - $240K *

Lead the charge in shaping the legal function at a dynamic healthcare company. Collaborate across teams to navigate complex regulations, drive compliance, and support innovative solutions for high-nee...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$135K - $160K *

Join a team that's driving technical pre-sales excellence by blending hands-on solution architecture with people management, enhancing expertise, and delivering tailored cloud solutions for client suc...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Support and enhance large-scale data center automation through hands-on PLC programming. Collaborate with clients and teams to ensure precise integration of critical HVAC and mechanical systems for re...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$112K - $196K *

Advance virtual OSINT instruction and curriculum development, enhancing training effectiveness through innovative content and hands-on exercises while collaborating with experts to meet operational ne...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Drive high-value cost management services for a large-scale data center program, ensuring effective client communication and leadership across multiple workstreams while enhancing cost management proc...

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$63K - $111K *

Unlock potential by joining a collaborative team focused on geotechnical and environmental engineering projects, driving innovative designs, investigations, and solutions to support sustainable constr...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Real Estate & Construction

$191K - $249K *

Shape the future of AI-driven audit solutions by leading product strategy and execution for innovative workflows in indirect tax. Drive impactful change while collaborating with cross-functional teams...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Lead the charge in developing and enhancing clinical education within a hybrid Doctor of Physical Therapy program, ensuring compliance with accreditation standards while fostering student success and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$75K - $105K *

Join a team that's dedicated to advancing customer success through technical sales and expert consultation. Drive performance improvements and foster lasting relationships as you manage key accounts i...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.