Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$123K - $164K *

Drive end-to-end design execution for major data center projects, leading multidisciplinary teams to ensure alignment with safety, sustainability, and commercial goals throughout the project lifecycle...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$180K - $215K *

Drive regional sales success by leading a high-performing team, executing launch strategies, and fostering customer relationships to achieve business objectives in a dynamic environment...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Elevate global economic insights by leveraging advanced analytics and machine learning to model and predict commodity market dynamics. Collaborate with cross-functional teams to transform complex data...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$103K - $160K *

Unlock potential by driving profitable growth in the polymer business through strategic sales initiatives and customer engagement in the CASE and Powder Resins markets...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$103K - $123K *

Lead the growth of a sales territory by building relationships and generating premium. Own your pipeline and leverage existing partnerships while prospecting new agencies. Drive results with autonomy...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Elevate your career by leading mechanical design for mission-critical facilities. Collaborate with teams, mentor junior engineers, and ensure project success through innovative solutions and precise e...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$128K - $252K *

Lead the charge in transforming banking and capital markets through strategic digital assets initiatives, overseeing product delivery and stakeholder collaboration while driving growth and modernizati...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$145K - $186K *

Shape the future of cybersecurity by leading operations, enhancing security controls, and ensuring compliance. Drive incident response, vulnerability management, and team development while collaborati...

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$62K - $117K *

Champion operational excellence by coordinating order fulfillment, shipping, and vendor partnerships. Drive continuous improvements in quality and efficiency while ensuring a seamless customer experie...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$120K - $150K *

Transform subscription retention strategies to drive growth and revenue. Own metrics, analyze data, and collaborate cross-functionally to enhance customer experience and optimize retention initiatives...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Champion the development of a comprehensive insider risk program, overseeing its design, implementation, and stakeholder engagement to secure critical AI infrastructure and ensure robust protection ag...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $110K *

Lead the charge in providing advanced remote technical support for complex security systems. Serve as a senior technical authority, mentoring junior engineers and resolving critical issues across ente...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $180K *

Lead enterprise IT initiatives by assessing environments, developing solution architectures, and overseeing implementations. Collaborate with stakeholders to ensure alignment with organizational stand...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$110K - $130K *

Drive project success by implementing Oracle Primavera P6 solutions, optimizing project controls, and integrating with Oracle Cloud applications to enhance scheduling, resource management, and financi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$150K - $180K *

Lead the charge in transforming Oracle HCM practices by driving strategic growth, fostering innovation, and building high-performing teams. Collaborate with clients and partners to deliver exceptional...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Staffing

$95K - $115K *

Drive product ownership and functional support for Oracle Fusion SCM and Fleet Management. Collaborate with stakeholders to resolve complex issues, enhance processes, and shape the product roadmap whi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$80K - $95K *

Accelerate your career by driving brand awareness and demand generation through innovative marketing strategies in a dynamic consulting environment. Collaborate with cross-functional teams to enhance...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Staffing

$110K - $130K *

Lead dynamic transmission planning projects, managing teams and client relations. Drive business development and project execution while mentoring talent and overcoming complex power system challenges...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$124K - $157K *

Join a team that's dedicated to enhancing patient care and safety. As a Staff Pharmacist, you'll lead pharmacy operations, support your team, and drive growth while ensuring compliance and quality ser...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Transform cloud infrastructure by leading strategy, team development, and automation. Drive security, reliability, and cost management while collaborating across functions to enhance operational excel...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $190K *

Grow your career with a leadership role overseeing Engineering, Data & AI capabilities. Drive strategy, establish operating models, and ensure technology delivery at enterprise scale while fostering a...

1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$135K - $180K *

Drive innovative electrical design solutions for high-density compute environments. Collaborate across teams to ensure compliance with industry standards while mentoring junior engineers. Make a signi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $210K *

Partner with us to drive innovative financial solutions in the healthcare sector. Leverage your Workday expertise for impactful implementations, collaborating closely with teams to transform operation...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$117K - $195K *

Champion innovative automation solutions by analyzing and documenting business processes. Collaborate with cross-functional teams to optimize workflows and deliver high-quality RPA implementations tha...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$60K - $110K *

Champion project success by overseeing store remodels and new builds across the US. Collaborate with teams to ensure timely, budget-friendly execution while maintaining high-quality standards. Travel...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.