Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Associate Counsel, Employment and Commercial
$110K - $130K *
Collaborate with HR and legal teams to provide comprehensive employment law support, drafting and negotiating contracts while ensuring compliance with regulations. Balance legal risks with business ob...
1 week ago
Senior Clinical Research Associate - Oncology
$105K - $140K *
Lead the charge in monitoring clinical study sites, ensuring data integrity and patient safety while collaborating with diverse teams to enhance study delivery and compliance with regulatory standards...
Reposted 1 week ago
$74K - $124K *
Elevate compensation strategies by transforming complex data into actionable insights. Collaborate with stakeholders to manage compensation programs, analyze trends, and recommend solutions that ensur...
1 week ago
Vice President, Franchise Sales Development - Extended Stay
$485K *
Transform franchise growth in the Extended Stay sector by leading strategic initiatives, managing a team of Regional Vice Presidents, and building key relationships to enhance development opportunitie...
1 week ago
$162K - $207K *
Lead the charge in implementing and optimizing SAP Vistex solutions, translating business strategies into technical architecture while managing cross-functional teams and project deliverables for enha...
1 week ago
$85K - $100K *
Advance patient care as a Medical Oncology APP, focusing on comprehensive clinical coordination, case management, and nursing research while ensuring adherence to state and federal regulations in a su...
1 week ago
CIAM & IDAM Services & Enablement Lead
$129K - $185K *
Unlock potential by leading the Customer Identity & Access Management function, overseeing CIAM platform operations, and driving identity strategy across global digital ecosystems while collaborating...
1 week ago
Professional (Senior) Sales Representative, Pain - New Orleans W, LA
$100K - $162K *
Unlock potential by developing effective strategies and relationships to drive sales growth in the territory, ensuring compliance with regulations and high levels of customer engagement through effect...
Reposted 1 week ago
Director, Product Management – Global Investor & Distribution Solutions (GIDS) - PA-UID-PROD-Q4-N001
$175K - $225K *
Accelerate your career by owning the strategy and execution of innovative outsourced operations and technology products for asset managers, driving market research, product design, and commercializati...
1 week ago
Product Builder, Merchant Portal
$104K - $145K *
Elevate product development by defining, designing, and prototyping features for a merchant portal, leveraging AI tools and user feedback to enhance payment processing solutions rapidly and effectivel...
1 week ago
Sr. Analyst, Pricing Analytics
$89K - $134K *
Explore your potential as a key analytical consultant, leveraging data to optimize drug pricing and enhance pharmacy relationships while collaborating across multiple functions to drive strategic grow...
1 week ago
Transmission Line Design and Maintenance Engineer
$71K - $172K *
Execute innovative design and maintenance solutions for high-voltage transmission lines, managing multiple projects while ensuring compliance with safety standards and engineering regulations. Collabo...
Reposted 1 week ago
RN Clinical Manager –Liberty/Centerville Locations Ambulatory Subspecialty Sites
$103K - $134K *
Shape the future of youth healthcare by overseeing clinical operations across multiple sites, enhancing patient care quality, and fostering staff development in a dynamic ambulatory environment...
Reposted 1 week ago
Director, AI Platforms & Engineering
$105K - $165K *
Shape the future of AI platforms by leading strategy, architecture, and engineering for scalable, secure solutions. Drive innovation while ensuring compliance and operational excellence across enterpr...
1 week ago
Neurology Territory Business Manager (Overlay), Minneapolis
$140K - $192K *
Lead the charge in driving demand generation for the Neurology Franchise by collaborating with healthcare professionals and internal teams to achieve sales objectives and enhance patient care within y...
1 week ago
$136K - $187K *
Lead patient education and support initiatives for individuals affected by generalized Myasthenia Gravis. Collaborate with caregivers and healthcare teams to enhance treatment coordination and empower...
1 week ago
$136K - $187K *
Join a team that's dedicated to empowering patients with generalized Myasthenia Gravis through education and support. As a key point of contact, you'll coordinate care, provide resources, and ensure c...
1 week ago
Neurology Territory Business Manager (Overlay), Denver
$140K - $192K *
Join a team that's dedicated to driving demand in the Neurology Franchise. Collaborate with local TBMs and healthcare professionals to achieve sales objectives and enhance patient care through strateg...
1 week ago
$136K - $187K *
Unlock potential by serving as a vital resource for patients and caregivers, providing education and support for managing generalized Myasthenia Gravis while coordinating treatment and navigating insu...
1 week ago
$168K - $231K *
Join a dynamic team to lead Nurse Case Managers, enhancing patient support and education throughout treatment journeys while ensuring compliance and quality in case management processes...
1 week ago
Supplier Quality Program Manager - Remote
$134K - $176K *
Lead the development and execution of a national supplier quality program, ensuring compliance and fostering strong supplier relationships to enhance operational efficiency and project success across...
1 week ago
Power BI / Insurance Analytics Developer
$95K - $115K *
Drive impactful analytics by designing and maintaining Power BI dashboards, leveraging SQL expertise to extract insights from complex datasets, and applying insurance knowledge to enhance reporting so...
1 week ago
Senior Developer- Python Full Stack
$120K - $145K *
Drive the design and implementation of innovative pricing tools, enhancing market readiness and efficiency. Collaborate across teams to establish technical standards and mentor junior developers while...
1 week ago
$210K - $250K *
Lead the Hospital Medicine team, enhancing inpatient care through clinical excellence and mentorship. Engage in a balanced role with a focus on patient outcomes, while managing a dedicated team in a s...
1 week ago
Regional Hospice RN (AZ/ CA/ NM)
$98K - $112K *
Join a dedicated team providing compassionate hospice care across multiple locations. Collaborate with interdisciplinary teams to ensure quality patient outcomes while adapting to diverse clinical env...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.