Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$153K - $208K *

Partner with us to architect and execute integrated marketing campaigns that drive enterprise product launches and enhance brand storytelling, ensuring alignment across multiple teams and channels for...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$80K - $95K *

Champion operational excellence by leading Salesforce environments, ensuring technical stability and strategic optimization while collaborating with IT and business stakeholders to drive efficiency an...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K *

Champion sales excellence by leading and developing high-performing teams, driving revenue growth, and optimizing processes across product lines. Foster a culture of accountability while aligning stra...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$109K - $175K *

Unlock opportunities in Spatial Proteomics by bridging scientific insights with commercial strategies. Collaborate with regional teams to drive sales, engage KOLs, and accelerate market adoption throu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $155K *

Drive business growth by leading consulting and system studies for T&D infrastructure, focusing on data centers. Engage with industry leaders and ensure high-quality technical solutions while supporti...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$110K - $130K *

Empower your career by leading sales strategies across the US. Collaborate with a dynamic team to drive growth, develop client relationships, and deliver impactful presentations while navigating indus...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$190K - $300K *

Champion scientific exchange and research initiatives in gastrointestinal immunology, engaging with key scientific leaders to enhance understanding and support clinical trials while fostering an inclu...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$105K - $110K *

Unlock your potential as you drive strategic growth in K-12 special education markets. Lead complex sales cycles, build trusted relationships, and shape innovative solutions that enhance educational o...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$180K - $190K *

Deliver innovative solutions by acquiring Fortune 500 clients, leading complex sales cycles, and building executive relationships. Drive value through AI insights and strategic partnerships, ensuring...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$96K - $159K *

Drive your career with a dynamic sales role focused on managing agency relationships, implementing growth strategies, and leveraging advanced analytics to achieve profitability and retention goals in...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$96K - $159K *

Join a team that's driving profitable growth through innovative sales strategies and strong relationships. You'll manage agency territories, optimize performance, and leverage advanced analytics to en...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$164K - $225K *

Develop and execute patient advocacy strategies, engaging with PAOs and cross-functional teams to elevate the patient voice and ensure successful partnerships for rare disease therapeutic areas...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Optimize strategic opportunities by leading cross-functional initiatives and applying AI-driven solutions to enhance business performance, while collaborating with senior leaders to drive impactful ch...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$107K - $171K *

Shape the market narrative for AI Agent Identity by leading product marketing initiatives. Own positioning, messaging, and commercial enablement for DNSid, translating complex innovations into compell...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$141K - $278K *

Drive supply chain transformation by leading design and optimization projects. Shape strategies, guide client discussions, and manage delivery while enhancing team capabilities and contributing to inn...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$141K - $278K *

Transform supply chain strategies by leading network design and optimization projects. Collaborate with clients to enhance operational efficiency and drive value through advanced analytics and innovat...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$134K - $265K *

Join a team that's transforming business landscapes by leading Oracle Cloud Financials implementations, driving efficiency, and enhancing decision-making for clients. Collaborate with stakeholders to...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$134K - $265K *

Transform business processes as you lead Oracle Cloud Financials implementations, guiding teams and clients through complex projects while enhancing efficiency and decision-making across organizations...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Join a team that's dedicated to enhancing patient care through clinical pharmacy expertise. Collaborate with healthcare professionals to optimize medication therapy and ensure safe, effective drug use...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to crafting innovative software solutions. You'll design, develop, and maintain applications while collaborating with peers to ensure best practices and adherence to archi...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $200K *

Lead client engagements by leveraging tax expertise to drive revenue growth, manage complex planning discussions, and enhance client relationships while ensuring strategic alignment across teams for o...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $200K *

Lead a dynamic team of Equipment Sales Specialists to drive sales growth, enhance customer satisfaction, and innovate equipment offerings in the dental sector while collaborating with cross-functional...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $102K *

Champion customer success by guiding Mid-Market clients through the deployment and adoption of IoT solutions, ensuring they maximize value from our technology while building strong relationships acros...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Drive strategic insights by analyzing cross-functional data to enhance decision-making. Collaborate with teams to build a trusted business intelligence framework, delivering actionable recommendations...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Unlock the potential of seamless data exchange by analyzing EDI requirements, developing maps, and supporting integrations. Collaborate with partners to ensure efficient transactions and enhance elect...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.