Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$120K - $145K *

Lead and enhance our 24x7 security operations team, driving effective incident response and operational excellence across diverse customer environments while fostering talent and improving detection c...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $165K *

Transform the defined benefit landscape by driving growth for ProAdmin. Build strategic partnerships and engage directly with plan sponsors to enhance confidence in benefit calculations and streamline...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $135K *

Join a team that's dedicated to driving client success through strategic partnerships. Manage complex client relationships, lead program launches, and deliver impactful results while collaborating wit...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$100K - $120K *

Transform the future of ERP by leading innovative product strategies that leverage AI to enhance workflows for lumber and building materials. Collaborate with cross-functional teams to deliver custome...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$88K - $105K *

Advance your career by leading complex aerodynamic testing initiatives. Collaborate with a multi-disciplinary team to design, execute, and analyze wind tunnel tests, ensuring data integrity and safety...

5 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $115K *

Execute product safety assessments and compliance testing for complex machinery. Collaborate with clients to ensure adherence to global standards while conducting evaluations and preparing technical r...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Technical Services

$80K - $95K *

Unlock potential by leading a multidiscipline team in architectural projects, ensuring code compliance, coordinating workflows, and delivering high-quality documents on schedule while fostering collab...

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$182K - $303K *

Unlock strategic potential by leading NAPD's planning processes, aligning priorities, and driving execution across a complex healthcare landscape. Collaborate with senior leaders to shape decisions an...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Join a team that's dedicated to clinical excellence, leading therapy initiatives to enhance patient outcomes and therapist engagement. Drive change through collaboration, data analysis, and operationa...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Make a meaningful impact on patient care by optimizing medication therapy in a collaborative hospital environment. Engage with interdisciplinary teams to enhance patient outcomes and drive quality ini...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$85K - $100K *

Advance your veterinary career by providing compassionate care and collaborating with a supportive team. Enjoy flexible scheduling, mentorship, and opportunities for professional growth in a welcoming...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Lead the charge in advancing small animal veterinary care, focusing on exotic and avian medicine. Collaborate with a dedicated team to provide exceptional service and mentorship while enjoying a suppo...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$201K - $251K *

Lead the development and execution of US Medical Affairs strategy for PDAC, collaborating with cross-functional teams to translate insights into actionable medical priorities and support launch readin...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$123K - $154K *

Accelerate your career by leading business development for utility-scale solar and energy storage projects. Drive client engagement, manage RFP responses, and collaborate with teams to secure new oppo...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$95K - $115K *

Transform banking analytics by developing and optimizing financial crime detection models. Leverage your expertise in Python and SQL to analyze complex datasets, enhance model performance, and collabo...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$124K - $187K *

Join a dynamic team as a Project Manager, overseeing complex renewable energy projects and ensuring safety, quality, and budget objectives across multiple disciplines and stakeholders to drive sustain...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$87K - $157K *

Engineer innovative microgrid systems, integrating PV, BESS, and distribution assets. Lead detailed electrical designs, ensuring compliance and constructability from concept to construction support. D...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Technical Services

$163K - $280K *

Lead the end-to-end operations of a $30M grant program, managing partnerships, budgets, and cross-functional teams to drive impactful AI research and benchmarks. Inspire collaboration and innovation w...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Shape the future of civil construction by leading field operations, ensuring safety, and fostering strong relationships with stakeholders. Drive project success through effective logistics planning an...

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $145K *

Innovate and optimize CI/CD pipelines while integrating AI-driven automation to enhance developer enablement. Collaborate with agile teams to ensure secure, efficient software delivery and champion a...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$165K - $220K *

Transform the SLED sales landscape by leading a high-performing team, driving new business, and fostering relationships within the Public Sector. Collaborate across departments to achieve ambitious sa...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$116K - $216K *

Lead a team in assessing credit risk through comprehensive reviews, ensuring compliance and quality in loan portfolios. Drive insights and improvements while collaborating with stakeholders to enhance...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$207K - $244K *

Elevate pricing strategies as you lead experimentation efforts, collaborate with cross-functional teams, and deliver actionable insights to enhance decision-making and drive business growth through da...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$86K - $108K *

Optimize financial integrity as a Senior Accountant, managing general ledger functions, supporting month-end closes, and collaborating cross-functionally to ensure accurate reporting in a dynamic, hig...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Drive your career with a leadership role overseeing marketing operations, guiding teams to enhance sales processes, optimize technology strategies, and deliver impactful data analysis for informed dec...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.