Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Executive Director - Clinical Services
$120K - $160K *
Shape impactful clinical initiatives that enhance care delivery and outcomes. Collaborate with leaders to implement evidence-based programs, driving quality and access across the organization while fo...
5 days ago
$120K *
Lead the charge in securing AI applications by building robust defenses and controls across our core security platforms. This hands-on role involves engineering, deploying, and operating security meas...
5 days ago
Principal Cloud Security Engineer
$159K - $210K *
Unlock potential by leading cloud security architecture and posture management across multi-subscription environments. Drive automation, establish guardrails, and collaborate with teams to ensure secu...
5 days ago
$120K - $157K *
Accelerate growth in our digital health programs by owning the member funnel, driving experimentation, and enhancing retention strategies. Collaborate cross-functionally to optimize user experience an...
5 days ago
$175K - $232K *
Join a dynamic team as you lead partnership growth initiatives, driving revenue through strategic relationships with health plans, brokers, and consultants. Collaborate across departments to achieve m...
5 days ago
Senior Cloud Security Engineer
$135K - $216K *
Champion cloud security by leading proactive threat hunting and vulnerability remediation across diverse cloud environments, ensuring robust protection for 70+ customer tenants while collaborating wit...
5 days ago
Oracle Database Administrator (DBA)
$112K - $179K *
Elevate your career by implementing and optimizing Oracle database systems for a global mission. Join a dynamic team to ensure operational excellence and security in a 24x7 environment, while supporti...
5 days ago
Senior GIS Developer - Spatial Data & Integration
$66K - $106K *
Join a team that's transforming federal species data integration by leading the production of comprehensive range maps for marine and anadromous taxa, ensuring compliance with established standards an...
5 days ago
Systems Engineer – Aviation Weather & NAS Integration
$112K - $179K *
Join us in shaping the future of aviation weather systems. This role integrates engineering efforts across teams to modernize critical weather observation systems, ensuring safety and efficiency in th...
5 days ago
$104K - $166K *
Lead the charge in optimizing multi-cloud Kubernetes environments, driving incident resolution, and mentoring teams. Leverage your expertise in Azure Kubernetes Service and agentic-runtime to enhance...
5 days ago
$146K - $234K *
Empower your career by guiding engineering teams in multi-discipline systems engineering, ensuring timely and accurate geospatial intelligence solutions across national and allied systems...
5 days ago
$86K - $138K *
Empower your career by designing and automating AWS cloud infrastructure, ensuring secure software delivery for mission-critical applications while collaborating with cross-functional teams to enhance...
5 days ago
Medical Review Analyst - Medicare
$66K - $106K *
Elevate your career by conducting medical reviews and applying clinical judgment to detect fraud and ensure compliance. Collaborate with agencies to develop cases and support investigations while util...
5 days ago
$99K - $139K *
Join a dynamic team to develop and maintain innovative web applications, enhancing user experience and security. Collaborate with stakeholders to gather requirements, create documentation, and ensure...
5 days ago
Aviation Industrial /Organizational Psychologist
$120K - $155K *
Join a team that's pioneering the integration of behavioral science into aviation modernization. Drive workforce adaptation and enhance operational safety through strategic planning and execution in a...
Reposted 5 days ago
Federal Growth Executive – Civilian Agencies
$145K - $185K *
Lead federal growth initiatives by driving sales, building relationships, and converting opportunities into revenue. This hands-on role requires strategic thinking and execution to enhance agency part...
5 days ago
Director, Product Management and Downstream Marketing
$150K - $180K *
Shape the future of life sciences by leading a high-performing Product Management and Marketing team. Drive portfolio strategy, commercialization, and business growth while collaborating across functi...
5 days ago
Business / Data Analyst Level III
$85K - $120K *
Join a team that's dedicated to enhancing data-driven decision-making for VA modernization initiatives. Leverage your analytical skills to assess workflows, document processes, and deliver actionable...
5 days ago
$110K - $165K *
Unlock potential by designing and maintaining robust data pipelines and Power BI models to transform operational data into actionable insights for stakeholders, ensuring data integrity and performance...
5 days ago
Atlassian Migration Engineer III
$130K - $175K *
Unlock potential by modernizing enterprise Jira and Confluence environments, executing complex migrations, and integrating work management with development pipelines for impactful modernization initia...
5 days ago
$100K - $150K *
Optimize enterprise work-management tools by configuring and supporting Atlassian environments. Collaborate with teams to enhance usability, troubleshoot issues, and ensure effective onboarding while...
5 days ago
Project Manager, Business Implementation
$100K - $120K *
Transform business implementations by leading projects from inception to delivery. Leverage your expertise to ensure operational excellence and customer satisfaction while managing cross-functional te...
5 days ago
$100K - $120K *
Unlock potential by driving innovative solutions in corporate travel technology. This role focuses on programming, system integration, and enhancing agent workflows to boost productivity and operation...
5 days ago
$90K - $100K *
Engage with customers and drive revenue growth by managing accounts and pursuing new business opportunities. Utilize consultative selling to achieve sales targets while collaborating with internal tea...
5 days ago
Senior Enterprise Account Executive
$154K - $220K *
Join a team that's driving innovation in On-Demand Mobility and Fleet Technology. You'll cultivate strategic customer relationships, identify growth opportunities, and leverage HERE's advanced locatio...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.