Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$94K - $147K *

Join a team that's passionate about innovation and technical excellence. Drive the development of full-stack applications, mentor your colleagues, and collaborate with cross-functional teams to delive...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$115K - $140K *

Unlock potential by providing exceptional clinical testing and psychotherapy services. Enjoy flexible scheduling, competitive compensation, and a supportive team environment while focusing on patient...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $127K *

Contribute to product strategy and lifecycle management, ensuring alignment with customer needs and market trends. Collaborate with cross-functional teams to drive product development and sustainment...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$80K - $95K *

Champion capacity building initiatives to enhance refugee integration and community engagement. Oversee program development, compliance, and staff management while fostering collaboration and innovati...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$135K - $160K *

Elevate your career by driving new business initiatives and enhancing operational efficiency. Collaborate with cross-functional teams to resolve issues and optimize processes, ensuring seamless execut...

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Architect the future of our Builder Platform by leading the design and operation of scalable agent workflows. Collaborate across teams to enhance productivity and drive innovation in AI infrastructure...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$108K - $130K *

Drive innovative solutions as you lead a dynamic IT team, managing critical applications that enhance business operations. Collaborate with stakeholders to ensure stability and continuous improvement...

5 days ago

  •   5 - 7 years exp.  •   Transportation

$88K - $115K *

Analyze compensation strategies and drive data-informed decisions to enhance pay equity and market competitiveness. Collaborate with HR and business leaders to optimize compensation programs and suppo...

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$88K - $115K *

Analyze and enhance compensation programs through data-driven insights, collaborating with HR and business leaders to ensure competitive and equitable pay practices aligned with organizational goals...

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$71K - $106K *

Empower patient care by providing clinical support as a Registered Nurse. Collaborate with healthcare teams to assess, intervene, and enhance patient outcomes in a dynamic maternal newborn environment...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$133K - $150K *

Champion innovative finance solutions by owning core accounting operations, driving automation, and enhancing financial reporting. Collaborate across teams to build a scalable finance function that su...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$100K - $150K *

Unlock your potential by leading enterprise accounts, driving revenue growth, and building strategic relationships. Become the trusted partner for clients as you deliver value through tailored solutio...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $180K *

Lead a high-performing team of Solutions Architects to drive strategic market expansion and enhance presales execution. Collaborate across functions to ensure alignment and deliver impactful solutions...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Unlock potential by joining a dynamic team focused on legal research and writing. Collaborate with trial attorneys to craft persuasive documents that support clients in personal injury cases, ensuring...

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$80K - $95K *

Shape the future of environmental preservation by providing expert analysis and guidance on complex ecological projects. Collaborate with agencies and stakeholders to ensure compliance and promote sus...

5 days ago

  •   Less than 5 years exp.  •   Transportation

$75K - $90K *

Transform the legal landscape by providing essential research and writing support to trial attorneys, enhancing case strategies and maximizing client recovery in personal injury and civil litigation m...

St. Louis, MORemote

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$80K - $95K *

Engage in critical environmental assessments, providing expert guidance on complex ecological projects. Collaborate with agencies and stakeholders to ensure compliance with federal regulations while e...

5 days ago

  •   Less than 5 years exp.  •   Transportation

$114K - $144K *

Contribute to sales success by analyzing performance trends, optimizing processes, and collaborating cross-functionally. Shape the future of sales operations through strategic insights, innovative tec...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$188K - $245K *

Advance our longitudinal patient record by leading product strategy, ensuring data integrity, and enhancing clinical utility. Collaborate with cross-functional teams to deliver a unified view of patie...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Drive profitable growth and market share by leading a high-performing sales team, building strategic customer relationships, and collaborating cross-functionally to enhance commercial performance and...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Transportation

$88K - $105K *

Drive market growth by influencing engineering specifications for innovative drainage solutions. Collaborate with industry professionals to establish product presence and enhance relationships, ensuri...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Transform the municipal landscape by driving growth in separation solutions. Engage with decision-makers to enhance product adoption and market share while fostering strategic relationships across the...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$88K - $105K *

Elevate your career by driving market growth through strategic relationships with engineers. Influence product specifications and promote innovative drainage solutions across the North Central USA, ma...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Transform subcontractor engagement by leading qualification processes and building a robust network of partners to enhance federal construction projects. Collaborate across teams to ensure compliance...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$210K - $250K *

Transform behavioral healthcare by leading a premier facility, enhancing patient care, expanding services, and fostering community partnerships while ensuring operational excellence and compliance...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.