Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$115K - $130K *

Transform inventory accounting by leading a dedicated team to ensure accurate financial reporting and streamline processes across diverse operations, driving efficiency and clarity in COGS management...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$135K - $175K *

Empower your sales career by building and managing a robust pipeline through proactive prospecting and relationship-building. Thrive in a competitive environment where your performance directly impact...

3 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$170K - $200K *

Advance backend solutions and frontend features, collaborating across teams to build scalable systems and AI integrations, driving product growth from conception to execution...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Explore a pivotal role in shaping cloud infrastructure and DevOps practices. Lead initiatives to enhance software delivery, optimize processes, and mentor teams while ensuring compliance and security...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$210K - $235K *

Lead the charge in managing outsourced manufacturing operations, ensuring high-quality supply of clinical materials. Collaborate with cross-functional teams to drive operational excellence and complia...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$208K - $229K *

Join a team that's shaping innovative Salesforce solutions! As a Senior Solution Architect, you'll design technical solutions, guide project teams, and enhance client satisfaction while driving growth...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Technical Services

$128K - $268K *

Unlock potential by leading risk management for Commercial Card and Merchant Services. Collaborate across teams to assess risks, enhance controls, and ensure compliance, driving strategic growth and o...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$230K - $280K *

Champion B2B growth by leading a high-performance sales team, driving revenue across foodservice and retail channels. Own the sales funnel from lead generation to account expansion, ensuring a discipl...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$90K - $110K *

Drive full-cycle sales across your territory, self-sourcing leads and closing multi-stakeholder B2B software deals. Collaborate with Solutions Engineers to deliver tailored demos, consistently exceedi...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Drive application security excellence by collaborating with development teams to implement secure coding practices and conduct thorough security assessments throughout the software development lifecyc...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Elevate partner success by providing technical training and sales support. Collaborate with channel teams and partners to enhance their capabilities, drive sales opportunities, and foster a culture of...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$114K - $190K *

Engage with us to shape dynamic compensation strategies that drive enterprise growth, enhance employee engagement, and ensure compliance. Collaborate with HR leaders to tailor global rewards programs...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$132K - $220K *

Join a team that's driving innovation in cloud technology and engineering excellence. Lead and mentor engineers while shaping strategic direction for Fan and Club products, ensuring high performance a...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$103K - $138K *

Transform the secure access landscape by leading go-to-market strategies for innovative networking solutions. Collaborate across teams to craft compelling narratives that resonate with diverse buyers...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$115K *

Lead the charge in cultivating a donor-centered culture while managing a high-performing team. Drive strategic fundraising initiatives and oversee major gift prospects to enhance community engagement...

3 days ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$85K - $100K *

Champion quality assurance in clinical research by overseeing compliance, developing SOPs, and ensuring adherence to GCP standards. Collaborate with multidisciplinary teams to enhance study integrity...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$156K - $275K *

Transform machine learning infrastructure by deploying scalable models, building pipelines, and ensuring model health across product and marketing workflows. Collaborate with data scientists and engin...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Join a dynamic team to install and support Moxi robots in hospitals, ensuring seamless operations and training staff. Engage with diverse teams to enhance healthcare efficiency and improve patient car...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$200K - $235K *

Take ownership of impactful software projects, driving end-to-end development across backend and frontend technologies. Collaborate with cross-functional teams to enhance customer experiences and ensu...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$96K - $160K *

Accelerate progress at driving sales within assigned territories by collaborating with field teams and partners. Build relationships, close deals, and utilize innovative sales techniques to maximize r...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$240K - $260K *

Join a dynamic team to manage and grow Tier 1 customer relationships, driving account retention and revenue growth through strategic engagement and tailored solutions across diverse verticals...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$88K - $102K *

Transform the future of AI operations by managing enterprise AI systems, ensuring seamless integrations, and optimizing performance. Collaborate with cross-functional teams to enhance reliability and...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Join a dynamic sales team to drive growth in the clean energy sector by building relationships with utility customers and selling innovative DERMS and VPP solutions across key markets. Your expertise...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$149K - $186K *

Lead the evolution of product operations by designing systems that enhance planning, launch readiness, and customer insights. Collaborate with leadership to drive strategic initiatives and ensure alig...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $143K *

Drive innovative programming solutions by developing, testing, and maintaining secure code and scripts. Collaborate with cross-functional teams to enhance applications and ensure quality through rigor...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.