Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Inventory Cost Accounting Manager
$115K - $130K *
Transform inventory accounting by leading a dedicated team to ensure accurate financial reporting and streamline processes across diverse operations, driving efficiency and clarity in COGS management...
3 days ago
$135K - $175K *
Empower your sales career by building and managing a robust pipeline through proactive prospecting and relationship-building. Thrive in a competitive environment where your performance directly impact...
3 days ago
Senior Software Engineer, Python
$170K - $200K *
Advance backend solutions and frontend features, collaborating across teams to build scalable systems and AI integrations, driving product growth from conception to execution...
Reposted 3 days ago
$150K - $180K *
Explore a pivotal role in shaping cloud infrastructure and DevOps practices. Lead initiatives to enhance software delivery, optimize processes, and mentor teams while ensuring compliance and security...
3 days ago
Director, CMC External Manufacturing
$210K - $235K *
Lead the charge in managing outsourced manufacturing operations, ensuring high-quality supply of clinical materials. Collaborate with cross-functional teams to drive operational excellence and complia...
3 days ago
$208K - $229K *
Join a team that's shaping innovative Salesforce solutions! As a Senior Solution Architect, you'll design technical solutions, guide project teams, and enhance client satisfaction while driving growth...
3 days ago
Director, Commercial Sales Performance Management
$128K - $268K *
Unlock potential by leading risk management for Commercial Card and Merchant Services. Collaborate across teams to assess risks, enhance controls, and ensure compliance, driving strategic growth and o...
Reposted 3 days ago
$230K - $280K *
Champion B2B growth by leading a high-performance sales team, driving revenue across foodservice and retail channels. Own the sales funnel from lead generation to account expansion, ensuring a discipl...
3 days ago
$90K - $110K *
Drive full-cycle sales across your territory, self-sourcing leads and closing multi-stakeholder B2B software deals. Collaborate with Solutions Engineers to deliver tailored demos, consistently exceedi...
Reposted 3 days ago
Sr. Application Security Engineer
$120K - $145K *
Drive application security excellence by collaborating with development teams to implement secure coding practices and conduct thorough security assessments throughout the software development lifecyc...
3 days ago
$95K - $115K *
Elevate partner success by providing technical training and sales support. Collaborate with channel teams and partners to enhance their capabilities, drive sales opportunities, and foster a culture of...
3 days ago
$114K - $190K *
Engage with us to shape dynamic compensation strategies that drive enterprise growth, enhance employee engagement, and ensure compliance. Collaborate with HR leaders to tailor global rewards programs...
Reposted 3 days ago
$132K - $220K *
Join a team that's driving innovation in cloud technology and engineering excellence. Lead and mentor engineers while shaping strategic direction for Fan and Club products, ensuring high performance a...
3 days ago
Senior Lead Product Marketing Manager, SASE and Public Sector
$103K - $138K *
Transform the secure access landscape by leading go-to-market strategies for innovative networking solutions. Collaborate across teams to craft compelling narratives that resonate with diverse buyers...
3 days ago
Associate Vice President of Philanthropy
$115K *
Lead the charge in cultivating a donor-centered culture while managing a high-performing team. Drive strategic fundraising initiatives and oversee major gift prospects to enhance community engagement...
3 days ago
Clinical Research QA Specialist
$85K - $100K *
Champion quality assurance in clinical research by overseeing compliance, developing SOPs, and ensuring adherence to GCP standards. Collaborate with multidisciplinary teams to enhance study integrity...
3 days ago
Staff Machine Learning Engineer
$156K - $275K *
Transform machine learning infrastructure by deploying scalable models, building pipelines, and ensuring model health across product and marketing workflows. Collaborate with data scientists and engin...
3 days ago
$80K - $95K *
Join a dynamic team to install and support Moxi robots in hospitals, ensuring seamless operations and training staff. Engage with diverse teams to enhance healthcare efficiency and improve patient car...
3 days ago
Senior Software Engineer, Pentest Experience
$200K - $235K *
Take ownership of impactful software projects, driving end-to-end development across backend and frontend technologies. Collaborate with cross-functional teams to enhance customer experiences and ensu...
3 days ago
Veeam Kasten, Sales Specialist (Remote US - Phoenix or Atlanta preferred)
$96K - $160K *
Accelerate progress at driving sales within assigned territories by collaborating with field teams and partners. Build relationships, close deals, and utilize innovative sales techniques to maximize r...
3 days ago
Senior Account Manager (Pacific, Mountain, or Central time zone)
$240K - $260K *
Join a dynamic team to manage and grow Tier 1 customer relationships, driving account retention and revenue growth through strategic engagement and tailored solutions across diverse verticals...
3 days ago
Digital Workplace Platform Administrator
$88K - $102K *
Transform the future of AI operations by managing enterprise AI systems, ensuring seamless integrations, and optimizing performance. Collaborate with cross-functional teams to enhance reliability and...
3 days ago
$100K - $120K *
Join a dynamic sales team to drive growth in the clean energy sector by building relationships with utility customers and selling innovative DERMS and VPP solutions across key markets. Your expertise...
3 days ago
Staff Product Operations Manager
$149K - $186K *
Lead the evolution of product operations by designing systems that enhance planning, launch readiness, and customer insights. Collaborate with leadership to drive strategic initiatives and ensure alig...
3 days ago
$95K - $143K *
Drive innovative programming solutions by developing, testing, and maintaining secure code and scripts. Collaborate with cross-functional teams to enhance applications and ensure quality through rigor...
3 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.