Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$112K - $189K *

Join us to ensure safe, effective medication therapy while advancing pharmaceutical care. Collaborate with healthcare teams, educate future practitioners, and support drug-related research to optimize...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Join a dynamic team to drive the development of a cutting-edge marketplace, enhancing provider products and economic incentives while collaborating closely with engineering and operations to transform...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Lead the design and governance of clinical ontologies and terminology services, ensuring data quality and alignment with product needs. Collaborate cross-functionally to enhance data normalization and...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$192K - $288K *

Join a team that's driving strategic initiatives in Neuroscience and Oncology. In this pivotal role, you'll partner with leadership to enhance operations, manage budgets, and streamline workforce plan...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $145K *

Unlock potential by bridging business needs with technical solutions. Collaborate with stakeholders to define requirements, manage product backlogs, and ensure successful delivery of ServiceNow capabi...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$230K - $345K *

Shape the future of late-stage oncology clinical trials by leading strategic initiatives, ensuring operational excellence, and fostering cross-functional partnerships to drive successful trial executi...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform the renewable energy landscape by managing data portfolios, analyzing project performance, and enhancing financial reporting. Collaborate with cross-functional teams to drive strategic energ...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$201K - $309K *

Elevate security standards by leading the development of innovative software solutions. Collaborate with cross-functional teams to integrate robust security measures, ensuring the integrity of applica...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Join us to drive strategic relationships with enterprise customers, optimizing IGEL technology solutions. This hands-on role balances technical expertise with customer management, focusing on the Fina...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $200K *

Elevate the People function as a strategic partner, driving talent strategy, organizational design, and culture in a dynamic, global environment. Shape leadership effectiveness and enhance employee ex...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$94K - $157K *

Unlock potential by joining our team as a Data Analyst, where you'll leverage your expertise in data manipulation and visualization to support key Federal clients, driving impactful solutions through...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $185K *

Innovate the future of energy by leading the commissioning of electrical substations. Oversee testing, validation, and project management while collaborating with diverse teams across the nation to en...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $170K *

Shape the future of cloud solutions by architecting and optimizing advanced contact centers. Collaborate with cross-functional teams to leverage AI and AWS technologies, enhancing customer experiences...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Staffing

$73K - $95K *

Advance security measures by monitoring, analyzing, and remediating risks across the enterprise. Collaborate with IT teams to enhance security posture, focusing on threat detection, vulnerability mana...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $140K *

Lead PBM compliance audits, ensuring adherence to state regulations and industry standards. Supervise examiners, manage client relationships, and adapt to a fast-paced environment while driving progra...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$118K - $217K *

Unlock potential by developing cutting-edge rendering solutions for a major video game. Collaborate with engineers and artists to enhance visual fidelity and optimize performance in a large-scale, ope...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Media

$150K - $180K *

Lead and develop a high-performing team of enterprise account executives, driving revenue growth and shaping sales strategies in the finance sector. Engage with senior decision-makers and manage compl...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Unlock potential by leading tax engagements, mentoring teams, and delivering exceptional client service. Thrive in a collaborative environment while managing multiple projects and driving growth for p...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$176K - $220K *

Lead the charge in driving sustainable revenue growth by managing a high-performing team of Account Executives focused on acquiring new clients in the financial sector, ensuring effective sales execut...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Engineer innovative fraud detection models and features to identify high-risk activities while ensuring a seamless experience for legitimate customers. Collaborate with teams to translate insights int...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Join a team that's shaping the future of DevOps by designing and implementing CI/CD pipelines with cutting-edge technologies. Collaborate with customers and cross-functional teams to enhance their Dev...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Empower the Private Banking division by leading sales efforts, ensuring operational excellence, and fostering team development to achieve strategic goals while maintaining compliance and enhancing cli...

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Shape your career by leading integrated marketing campaigns that drive customer engagement and new business growth. Collaborate with cross-functional teams to enhance customer adoption and pipeline de...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $183K *

Join a team that's driving growth by acquiring and managing Mid-Market accounts. You'll identify prospects, manage the sales cycle, and build lasting relationships to exceed revenue targets in a dynam...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Business Services

$88K - $105K *

Champion regional marketing initiatives by aligning with sales to create impactful programs that drive pipeline growth and enhance community engagement. Manage budgets, logistics, and reporting to ens...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.