Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$92K - $153K *

Join a team that's dedicated to enhancing patient access by managing reimbursement challenges and providing education to healthcare providers. This role requires strong relationship-building skills an...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$190K - $267K *

Drive impactful ad experiences by leveraging your frontend expertise in JavaScript and TypeScript. Collaborate with cross-functional teams to enhance user engagement and optimize ad performance across...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Media

$81K - $128K *

Unlock potential by shaping integrated corporate communications strategies that connect software innovation with community impact, bridging B2B and B2C narratives to advance fraud prevention and eleva...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$261K - $308K *

Transform Women's Health engineering by leading a high-impact team to deliver innovative software solutions. Collaborate across functions to shape strategy and drive organizational excellence while en...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$113K - $147K *

Pioneer innovative solutions as a Microsoft Power Platform Architect, leading enterprise-grade design and implementation. Collaborate with stakeholders to enhance efficiency, automate processes, and d...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Shape the future of data protection by leading a high-performing team of analysts. Drive incident response, enhance security strategies, and collaborate with clients to mitigate risks in a fast-paced...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Partner with us to shape the future of talent acquisition and employee engagement. Lead strategies that attract, retain, and support exceptional talent while enhancing the employee experience across a...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$135K - $160K *

Shape the future of partner marketing by building and executing joint plans with key resellers and distributors, driving engagement and pipeline growth through innovative campaigns and strategic commu...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Unlock your potential as a Senior Applied AI Engineer, leading teams to design and deliver impactful AI solutions. Drive technical excellence and mentor engineers while shaping the future of AI system...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$172K - $269K *

Lead and modernize global security operations, managing a distributed team while enhancing detection strategies and incident response. Drive AI integration for efficiency and ensure accountability thr...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Transform healthcare data products by leading strategy, execution, and cross-functional collaboration. Drive product-market fit and commercialization for API-based solutions, ensuring alignment with c...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $155K *

Lead advanced analytics and statistical modeling to transform complex healthcare data into actionable insights, collaborating with cross-functional teams to solve strategic business challenges and enh...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $217K *

Join a team that's driving innovation in pharmacy operations, managing complex initiatives, and enhancing business performance. Collaborate with senior leaders to deliver measurable impact and shape t...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Accelerate sales growth by leading strategies and initiatives across the ANZ market. Collaborate with a multidisciplinary team to drive customer engagement, develop market strategies, and achieve reve...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Transform procurement operations by leading strategy and team management in a regulated manufacturing environment. Drive supplier performance, cost efficiency, and material availability to support pro...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Staffing

$466K - $500K+*

Unlock potential by developing scalable AI/ML model serving infrastructure. Collaborate cross-functionally to enhance performance and availability of high-traffic systems, driving innovation in a dyna...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$135K - $160K *

Join a team that's redefining onboarding experiences by optimizing customer activation and conversion. You'll lead the charge in creating a seamless journey for new users, ensuring they derive value f...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Drive cloud onboarding success by guiding application owners through migration complexities, ensuring effective communication and collaboration across teams to enhance operational efficiency and suppo...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$156K - $215K *

Empower innovation in advanced networking and enterprise solutions by defining strategic roadmaps and driving product lifecycle planning across high-speed networking, optical technologies, and AI plat...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $145K *

Empower enterprise growth by managing high-value accounts in a dynamic SaaS environment. Drive the full sales cycle, build executive relationships, and navigate complex negotiations to achieve impactf...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$140K - $185K *

Drive strategic growth by identifying and developing solution-specific opportunities within key accounts, leveraging industry expertise to influence client transformation initiatives and enhance sales...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Transform the Federal landscape by leading enterprise sales efforts, engaging with SES leaders, and driving digital transformation across major accounts. Collaborate with cross-functional teams to ach...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Information Technology

$73K - $98K *

Join a team that's dedicated to excellence in DRG auditing. Leverage your expertise in MS-DRG and APR-DRG coding to ensure accuracy and compliance while working remotely. Enjoy a collaborative environ...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$120K - $155K *

Join a team that's dedicated to nurturing and expanding client relationships in the Major Market sector. Drive revenue growth through upselling and cross-selling while ensuring long-term satisfaction...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$90K *

Shape the future of business analysis by connecting program needs with technical solutions. Leverage your Salesforce expertise to enhance workflows, gather requirements, and collaborate with stakehold...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.