Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$95K - $125K *

Join a dynamic team to enhance security in CI/CD pipelines, integrating advanced scanning tools and hardening infrastructure across cloud platforms. Drive vulnerability management and ensure complianc...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$95K - $105K *

Join a dynamic team to provision and manage cloud environments, automate deployments, and ensure robust cloud security. Leverage your expertise in AWS or Azure and OpenShift to drive cloud migrations...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Redefine pharmaceutical care by providing tailored drug management and clinical services. Collaborate with healthcare teams to enhance patient safety, participate in goal-oriented initiatives, and ens...

Reposted yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$160K - $190K *

Join a team that's dedicated to delivering exceptional anesthesia care. Provide critical support during surgical and diagnostic procedures while enhancing patient safety and comfort through your exper...

Reposted yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$108K - $147K *

Lead a dynamic team in enhancing member-centered care through effective utilization management. Drive quality improvement, ensure compliance, and foster strategic partnerships to optimize healthcare d...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$98K - $132K *

Deliver strategic sourcing solutions for Marketing Services, focusing on Content Production and Media. Collaborate cross-functionally to optimize supplier performance, drive innovation, and ensure com...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$147K - $200K *

Drive strategic category management initiatives for Full-Service CRO, collaborating across teams to optimize procurement processes, reduce costs, and enhance supplier performance while ensuring compli...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$107K - $180K *

Drive the strategy and operations of a dynamic contingent workforce program, enhancing governance and service delivery. Collaborate cross-functionally to implement scalable processes and support inter...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$74K - $118K *

Empower cross-functional teams by managing account workflows, resolving issues, and enhancing service quality. Utilize data-driven insights to streamline processes and mentor team members, ensuring a...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Real Estate & Construction

$225K - $280K *

Engage as a key technical resource for channel sales, driving success with global partners. Leverage your expertise in networking solutions to enhance relationships, deliver impactful demos, and suppo...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Drive growth by managing end-to-end sales cycles in the Energy sector, enhancing customer relationships, and executing strategies to exceed targets while collaborating with cross-functional teams for...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$68K - $105K *

Help us lead enterprise-wide incident responses and internal investigations into misconduct, ensuring compliance and effective fraud detection while collaborating across departments to uphold organiza...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$75K - $108K *

Unlock potential by managing diverse research projects, coordinating operations, and supporting data analysis. Collaborate with interdisciplinary teams to drive impactful educational initiatives and e...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$120K - $150K *

Transform the delivery landscape by leading cross-functional initiatives, mentoring analysts, and driving strategic solutions across business units and external partners. Engage deeply in project exec...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$83K - $104K *

Lead the charge in managing complex client programs, driving operational excellence and strategic direction while fostering strong stakeholder relationships and ensuring exceptional service delivery...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$188K - $265K *

Accelerate progress at the forefront of AI infrastructure by leading technical direction, ensuring platform architecture meets company ambitions, and fostering collaboration across engineering teams f...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$113K - $155K *

Champion quality excellence by executing business programs across manufacturing sites, collaborating with cross-functional teams to enhance product standards, manage consumer insights, and drive conti...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Food & Beverages

$214K - $309K *

Unlock potential by leading the design and implementation of advanced identity solutions for AI agents. Collaborate across teams to build scalable frameworks and drive technical excellence in a dynami...

RemoteRemote

Yesterday

  •   11 - 15 years exp.  •   Telecommunications & Hardware

$200K *

Drive technical excellence by translating creative visions into actionable plans. Oversee pre-production, CAD drafting, and on-site execution, ensuring projects are delivered safely, on time, and with...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$180K - $220K *

Lead the charge in transforming identity security marketing strategies, driving growth and market leadership. Oversee a dynamic team to enhance product positioning, execute go-to-market plans, and sha...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$95K - $125K *

Transform safety culture by leading project teams in compliance and incident prevention. Develop safety plans, conduct audits, and facilitate training to ensure a safe work environment on large constr...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Energy & Utilities

$130K - $157K *

Engineer innovative power system models and analyses to optimize utility-scale solar and storage solutions, working collaboratively with global teams to ensure compliance and advance SMA's technical c...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$164K - $240K *

Lead global procurement initiatives, optimizing sourcing strategies and cost structures to ensure high-quality products at competitive prices, while enhancing supply chain efficiencies and aligning wi...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$164K - $240K *

Lead strategic procurement initiatives to achieve optimal cost structures and maintain supply continuity. Collaborate across teams to drive innovation in sourcing and enhance quality standards while a...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$124K - $138K *

Shape the future of vendor relations by managing the RTV process, negotiating effectively, and collaborating cross-functionally to maximize recovery value and streamline operations within the supply c...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.