Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $111,063

Sort By: Relevance

$155K - $160K *

Drive the Order-to-Cash strategy, overseeing cash application, collections, and AR performance. Collaborate cross-functionally to optimize cash flow and enhance financial reporting, ensuring timely re...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Join a dynamic team as you optimize recipe and task build solutions, driving operational excellence and standardization. Collaborate across departments to enhance workflows and implement scalable proc...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Technical Services

$80K - $95K *

Transform healthcare processes by leading quality improvement initiatives. Utilize lean, six sigma, and change management expertise to enhance operational excellence, patient satisfaction, and efficie...

Today

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Shape the future of water and wastewater systems by leading projects from planning to optimization. Collaborate with diverse teams to deliver innovative solutions for municipal and industrial clients...

United StatesRemote

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  •   15+ years exp.  •   Technical Services

$80K - $95K *

Drive project success by managing operational aspects and liaising with stakeholders. Oversee schedules, assess issues, and develop solutions to ensure timely objectives. Integrate data for risk manag...

Today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$156K - $220K *

Unlock your potential by leading the paid media strategy in a transformative role involving creative innovation and team development, driving growth through data-driven decisions across multiple chann...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Media

$65K - $116K *

Drive exceptional client experiences by leading delivery operations, managing relationships, and leveraging analytics to identify service gaps. Collaborate cross-functionally to ensure seamless execut...

United StatesRemote

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  •   5 - 7 years exp.  •   Healthcare

$86K - $106K *

Drive advertiser growth by optimizing campaign performance and building strong client relationships. Collaborate with internal teams to enhance product offerings and ensure a seamless advertiser exper...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Consumer Technology

$180K - $220K *

Shape the future of healthcare delivery by leading operations in denials resolution and payment compliance. Drive performance, quality, and financial outcomes while building a high-performing team and...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Healthcare

$159K - $168K *

Discover impactful opportunities by leading state and local government affairs in the Midwest, advocating for public policies that enhance community engagement and support the growth of a leading e-co...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Consumer Technology

$210K - $250K *

Join a team that's driving strategic growth and profitability in healthcare solutions. Lead cross-functional initiatives, own P&L, and ensure client success while shaping market strategy and solution...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Healthcare

$91K - $118K *

Accelerate your career by driving technical solutions and proposals for engineered equipment. Collaborate with sales and engineering teams to ensure customer satisfaction and secure new business oppor...

United StatesRemote

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  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Transform the Industrial Segment by leading growth strategies across the Americas. Drive sales accountability, foster key relationships, and collaborate cross-functionally to enhance customer satisfac...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$134K - $170K *

Elevate partner success by managing key retail relationships, driving insights, and executing growth strategies. Collaborate cross-functionally to implement operational innovations and support the evo...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Consumer Technology

$193K - $309K *

Join a dynamic team to enhance cloud security capabilities, leading hands-on initiatives and shaping strategic direction. Collaborate across engineering teams to secure AWS environments and mentor pee...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Join a team that's transforming legacy systems into modern applications using Java and cloud technologies. Collaborate in an Agile environment to enhance performance, security, and reliability while e...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$193K - $309K *

Empower the development of innovative features on a high-traffic Orders platform, collaborating across teams to enhance architecture and tooling, ensuring efficient processing for over 1 billion order...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Enterprise Technology

$75K - $90K *

Join a team that's transforming supply chain planning through data-driven insights and cross-functional collaboration. Your expertise will enhance demand forecasting, inventory management, and strateg...

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Reposted today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$75K - $93K *

Join us to develop and deliver impactful training programs that enhance customer engagement and retention. Collaborate with leaders to identify performance gaps and create solutions that drive measura...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Lead data-driven strategies to enhance revenue growth across customer acquisition, retention, and expansion. Collaborate with cross-functional teams to establish integrated metrics and actionable insi...

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  •   8 - 10 years exp.  •   Manufacturing & Automotive

$225K - $265K *

Shape the future of oncology by leading clinical studies in early-phase development. Collaborate with multidisciplinary teams to drive innovative therapies and ensure high-quality execution of clinica...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the charge in optimizing fleet maintenance operations through strategic planning, data governance, and innovative automation. Drive results by enhancing system integration and building strong par...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$137K - $221K *

Empower innovation by designing and implementing core platform services for agent execution. Collaborate with cross-functional teams to build reliable APIs and workflows, ensuring robust performance a...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$210K - $250K *

Lead the transformation of data and AI into business value, driving strategy, governance, and adoption across the organization. Collaborate with stakeholders to enhance analytics maturity and build a...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Finance & Insurance

$100K - $120K *

Transform payment strategies by analyzing interchange and routing data to optimize costs and enhance performance. Leverage advanced analytics and automation to deliver actionable insights for stakehol...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.