Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$134K - $211K *

Lead strategic client relationships by leveraging analytics solutions to drive growth and innovation. Collaborate across teams to deliver tailored solutions, negotiate complex deals, and advocate for...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $130K *

Explore data-driven insights to enhance business intelligence and optimize performance. Collaborate with teams to analyze complex data, develop reporting structures, and present findings that influenc...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$192K - $266K *

Drive best-in-class travel support through strategic leadership and operational excellence. Oversee lodging, flights, and customer advocacy, fostering a culture of continuous improvement and exception...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$120K - $145K *

Execute accurate coding practices to ensure compliance and optimal reimbursement in a dynamic healthcare environment. Collaborate with clinical teams to maintain integrity and efficiency in revenue cy...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Inspire the evolution of commercial systems, enhancing integration and automation across platforms like Salesforce and HubSpot. Drive AI adoption to streamline workflows, ensuring data integrity and r...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$196K - $353K *

Champion growth in oncology by leading a high-performing sales team, driving strategy and execution for a groundbreaking mRNA therapy. Collaborate with partners to enhance customer engagement and achi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$145K - $190K *

Join a team dedicated to advancing oncology clinical trials. In this role, you’ll manage global studies, oversee vendors, collaborate with multi-disciplinary teams, and ensure compliance with regulato...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$113K - $170K *

Join us as a Principal Procore Administrator to lead configuration, governance, and enhancement of Procore for enterprise facilities and construction operations, ensuring data integrity while collabor...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$150K - $180K *

Lead the charge in overseeing a dynamic transaction management team, driving commercial real estate activities, and ensuring alignment with client goals while fostering staff development and operation...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $120K *

Take ownership of logistics operations across multiple sites, ensuring timely delivery of materials and efficient inventory management. Collaborate with teams to optimize procurement strategies and dr...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$94K - $164K *

Champion innovative business analysis strategies to drive enterprise alignment, enhance decision-making, and deliver measurable outcomes. Collaborate with leadership to shape initiatives that support...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $148K *

Unlock potential by determining risk acceptability and pricing for complex insurance accounts. Collaborate with brokers, analyze claims, and foster relationships to achieve production goals in a fast...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$115K - $181K *

Champion innovative multi-channel B2B marketing strategies to drive pipeline growth across North American accounts. Collaborate with teams to execute campaigns, optimize performance, and leverage AI f...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$215K - $250K *

Help us ensure the stability and reliability of our production systems by leading cross-functional teams, driving service improvements, and leveraging automation and AI to enhance operational efficien...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Lead the charge in driving strategic growth by managing a high-performing sales team, refining sales strategies, and fostering a culture of excellence to achieve ambitious revenue goals...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Join us to lead the School of Health Sciences, driving strategic growth and academic excellence while fostering partnerships and enhancing student success in a dynamic educational environment...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Drive strategic leadership and operational excellence in health sciences education, overseeing diverse programs and fostering partnerships to enhance student outcomes and workforce alignment in a dyna...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Lead strategic initiatives and operational oversight for a diverse suite of health science programs, fostering academic excellence and workforce alignment while ensuring compliance and enhancing stude...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Join us in providing strategic leadership and oversight for diverse healthcare programs, fostering innovation and academic excellence while enhancing student outcomes and community partnerships in a d...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$165K - $228K *

Lead and empower a dynamic product management team, driving strategy, commercialization, and market engagement for innovative healthcare solutions while fostering collaboration across global business...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$89K - $133K *

Drive innovative automation solutions for generator control systems, collaborating with cross-functional teams to enhance power system performance from design to commissioning, ensuring customer satis...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$89K - $133K *

Shape the future of power systems by delivering innovative automation and control solutions for generator control switchgear systems, collaborating with cross-functional teams to execute projects from...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$89K - $133K *

Transform power systems by delivering innovative automation solutions. Collaborate with cross-functional teams to design, implement, and support generator control systems, ensuring excellence from con...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $200K *

Transform your career by driving wealth management growth across the Pacific West. Collaborate with advisors and leaders to enhance product adoption and sales, leveraging market insights and relations...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$126K - $227K *

Lead the charge in manufacturing excellence by providing expert DFM and NPI support. Collaborate with teams to resolve technical issues, enhance processes, and drive continuous improvement while ensur...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.